-
1
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature. 2001;411366-411374
-
(2001)
Nature
, pp. 411366-411374
-
-
Hoeijmakers, J.H.1
-
2
-
-
0037169354
-
Cancer susceptibility and the functions of BRCA1 and BRCA2
-
Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 2002;108:171-182.
-
(2002)
Cell
, vol.108
, pp. 171-182
-
-
Venkitaraman, A.R.1
-
3
-
-
0031844311
-
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
-
Masson M, Niedergang C, Schreiber V, et al. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Biol. 1998;18:3563-3571.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 3563-3571
-
-
Masson, M.1
Niedergang, C.2
Schreiber, V.3
-
4
-
-
0142009654
-
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage
-
El-Khamisy SF, Masutani M, Suzuki H, et al. A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acid Res. 2003;31:5526-5533
-
(2003)
Nucleic Acid Res
, vol.31
, pp. 5526-5533
-
-
El-Khamisy, S.F.1
Masutani, M.2
Suzuki, H.3
-
5
-
-
38449088040
-
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases
-
Hassa PO, Hottiger MO. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci. 2008;13:3046-3082.
-
(2008)
Front Biosci
, vol.13
, pp. 3046-3082
-
-
Hassa, P.O.1
Hottiger, M.O.2
-
6
-
-
84872625067
-
Genetics of natural populations; recombination and variability of Drosophila pseudoobscura
-
Dobzhansky T. Genetics of natural populations; recombination and variability of Drosophila pseudoobscura. Genetics. 1946; 31:269-290.
-
(1946)
Genetics
, vol.31
, pp. 269-290
-
-
Dobzhansky, T.1
-
7
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005;434:917-921.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
-
8
-
-
17244375049
-
Specific killing of BRCA2-deficient tumors with inhibitors of poly(ADP-ribose) polymerase
-
Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumors with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005;434:913-917.
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
-
9
-
-
77149157867
-
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
-
Mendes-Pereira AM, Martin SA, Brough R, et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med. 2009;1:315-322.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 315-322
-
-
Mendes-Pereira, A.M.1
Martin, S.A.2
Brough, R.3
-
10
-
-
76649091939
-
ATM deficiency sensitizes mantle cell lymphoma cells to poly (ADP-ribose) polymerase-1 inhibitors
-
Williamson CT, Muzik H, Turhan AG, et al. ATM deficiency sensitizes mantle cell lymphoma cells to poly (ADP-ribose) polymerase-1 inhibitors. Mol Cancer Ther. 2010; 9:347-357.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 347-357
-
-
Williamson, C.T.1
Muzik, H.2
Turhan, A.G.3
-
11
-
-
78649321855
-
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo
-
Weston VJ, Oldreive CE, Skowronska A, et al. The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Blood. 2010;116:4578-4587.
-
(2010)
Blood
, vol.116
, pp. 4578-4587
-
-
Weston, V.J.1
Oldreive, C.E.2
Skowronska, A.3
-
12
-
-
77953677649
-
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition
-
Sourisseau T, Maniotis D, McCarthy A, et al. Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. EMBO Mol Med. 2010:130-142.
-
(2010)
EMBO Mol Med
, pp. 130-142
-
-
Sourisseau, T.1
Maniotis, D.2
McCarthy, A.3
-
13
-
-
33845999615
-
Essential role for nuclear PTEN in maintaining chromosomal integrity
-
Shen WH, Balajee AS, Wang J, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell. 2007;128:157-170.
-
(2007)
Cell
, vol.128
, pp. 157-170
-
-
Shen, W.H.1
Balajee, A.S.2
Wang, J.3
-
14
-
-
67650471685
-
Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, et al. Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009; 361:123-134.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
-
15
-
-
77955019276
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
-
Tutt A, Robson M, Garber JE, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet. 2010;376:235-244.
-
(2010)
Lancet
, vol.376
, pp. 235-244
-
-
Tutt, A.1
Robson, M.2
Garber, J.E.3
-
16
-
-
77955039099
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
-
Audeh MW, Carmichael J, Penson RT, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet. 2010;376:245-251.
-
(2010)
Lancet
, vol.376
, pp. 245-251
-
-
Audeh, M.W.1
Carmichael, J.2
Penson, R.T.3
-
17
-
-
80355129139
-
-
AstraZeneca press release. Available from, Accessed Aug 03
-
AstraZeneca press release. Available from: http://www.astrazeneca-us.com/search/?itemID=10810643. Accessed Aug 03 2011.
-
(2011)
-
-
-
18
-
-
80355139268
-
First-in-human trial of a poly(ADP)-ribose polymerase (PARP) inhibitor MK-4827 in advanced cancer patients with antitumor activity in BRCA-deficient tumors and sporadic ovarian cancers (soc)
-
abstr 3102
-
Schelman WR, Sandhu SK, Moreno Garcia V, et al. First-in-human trial of a poly(ADP)-ribose polymerase (PARP) inhibitor MK-4827 in advanced cancer patients with antitumor activity in BRCA-deficient tumors and sporadic ovarian cancers (soc). J Clin Oncol. 2011;29 (suppl; abstr 3102).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Schelman, W.R.1
Sandhu, S.K.2
Moreno Garcia, V.3
-
19
-
-
4944229642
-
Hallmarks of BRCAness in sporadic cancers
-
Turner N, Tutt A, Ashworth A. Hallmarks of BRCAness in sporadic cancers. Nat Rev Cancer. 2004;4:814-819.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 814-819
-
-
Turner, N.1
Tutt, A.2
Ashworth, A.3
-
20
-
-
77149138342
-
Triple-negative breast cancer: Role of specific chemotherapy agents
-
Isakoff SJ. Triple-negative breast cancer: role of specific chemotherapy agents. Cancer J. 2010;16:53-61.
-
(2010)
Cancer J
, vol.16
, pp. 53-61
-
-
Isakoff, S.J.1
-
21
-
-
0026709013
-
Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms
-
Futreal PA, Söderkvist P, Marks JR, et al. Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. Cancer Res. 1992;52:2624-2627.
-
(1992)
Cancer Res
, vol.52
, pp. 2624-2627
-
-
Futreal, P.A.1
Söderkvist, P.2
Marks, J.R.3
-
22
-
-
0034607234
-
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
-
Esteller M, Silva JM, Dominguez G, et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Nat Can Inst. 2000; 92:564-569.
-
(2000)
J Nat Can Inst
, vol.92
, pp. 564-569
-
-
Esteller, M.1
Silva, J.M.2
Dominguez, G.3
-
23
-
-
22744444015
-
Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer
-
Umetani N, Mori T, Koyanagi K, et al. Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer. Oncogene. 2005;24:4721-4727.
-
(2005)
Oncogene
, vol.24
, pp. 4721-4727
-
-
Umetani, N.1
Mori, T.2
Koyanagi, K.3
-
24
-
-
79953305446
-
Indicators of homologous recombination deficiency in breast cancer and association with response to neoadjuvant chemotherapy
-
Lips EH, Mulder L Hannemann J, et al. Indicators of homologous recombination deficiency in breast cancer and association with response to neoadjuvant chemotherapy. Ann Oncol. 2011;22:870-876.
-
(2011)
Ann Oncol
, vol.22
, pp. 870-876
-
-
Lips, E.H.1
Mulder, L.2
Hannemann, J.3
-
25
-
-
77955770116
-
DNA repair signature is associated with anthracycline response in triple negative breast cancer patients
-
Rodriguez AA, Makris A, Wu MF et al. DNA repair signature is associated with anthracycline response in triple negative breast cancer patients. Br Ca Res Treat. 2010;123;189-196.
-
(2010)
Br Ca Res Treat
, vol.123
, pp. 189-196
-
-
Rodriguez, A.A.1
Makris, A.2
Wu, M.F.3
-
26
-
-
79957940705
-
Cytoplasmic poly(adenosine diphosphateribose) polymerase expression is predictive and prognostic in patients with breast cancer treated with neoadjuvant chemotherapy
-
von Minkwitz G, Müller BM, Loibl S, et al. Cytoplasmic poly(adenosine diphosphateribose) polymerase expression is predictive and prognostic in patients with breast cancer treated with neoadjuvant chemotherapy. J Clin Oncol. 2011; 29:2150-2157.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2150-2157
-
-
von Minkwitz, G.1
Müller, B.M.2
Loibl, S.3
-
27
-
-
79955738892
-
PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: Possible implications for PARP-1 inhibitor therapy
-
Domagala P, Huzarski T, Lubinski J, et al. PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy. Breast Cancer Res Treat. 2011;127:861-869.
-
(2011)
Breast Cancer Res Treat
, vol.127
, pp. 861-869
-
-
Domagala, P.1
Huzarski, T.2
Lubinski, J.3
-
28
-
-
77955019962
-
Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer
-
abstr 3002
-
Gelmon KA, Hirte HW, Robidoux A, et al. Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer. J Clin Oncol.2010; 28:15s (suppl; abstr 3002)
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
, pp. 15
-
-
Gelmon, K.A.1
Hirte, H.W.2
Robidoux, A.3
-
29
-
-
80053135643
-
Phase II randomized placebo-controlled study of olaparib (AZD2281) in patients with platinum-sensitive relapsed serous ovarian cancer (PSR SOC)
-
abstr 5003
-
Ledermann JA, Harter P, Gourley C, et al. Phase II randomized placebo-controlled study of olaparib (AZD2281) in patients with platinum-sensitive relapsed serous ovarian cancer (PSR SOC) J Clin Oncol. 2011;29(suppl; abstr 5003).
-
(2011)
J Clin Oncol
-
-
Ledermann, J.A.1
Harter, P.2
Gourley, C.3
-
31
-
-
59349099497
-
First in human phase I study of BSI-201, a small molecule inhibitor of poly ADP-ribose polymerase (PARP) in subjects with advanced solid tumors
-
May 20 abstr 3577)
-
Kopetz S, Mita MM, Mok I, et al. First in human phase I study of BSI-201, a small molecule inhibitor of poly ADP-ribose polymerase (PARP) in subjects with advanced solid tumors. J Clin Oncol. 2008;26(May 20 suppl; abstr 3577).
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Kopetz, S.1
Mita, M.M.2
Mok, I.3
-
32
-
-
59349096529
-
A phase IB study evaluating BSI-201 in combination with chemotherapy in subjects with advanced solid tumors
-
May 20 abstr 3579)
-
Mahany JJ, Lewis N, Heath EI, et al. A phase IB study evaluating BSI-201 in combination with chemotherapy in subjects with advanced solid tumors. J Clin Oncol. 2008;26 (May 20 suppl; abstr 3579).
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Mahany, J.J.1
Lewis, N.2
Heath, E.I.3
-
33
-
-
78751610848
-
Iniparib plus chemotherapy in metastatic triple-negative breast cancer
-
O'Shaughnessy J, Osborne C, Pippen JE, et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med. 2011;364:205-14.
-
(2011)
N Engl J Med
, vol.364
, pp. 205-214
-
-
O'Shaughnessy, J.1
Osborne, C.2
Pippen, J.E.3
-
34
-
-
80052330662
-
A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin in metastatic triple-negative breast cancer
-
Abstr
-
O'Shaughnessy J, Schwartzberg LS, Danso MA, et al. A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin in metastatic triple-negative breast cancer. J Clin Oncol. 2011;29 (suppl; abstr 1007).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
O'Shaughnessy, J.1
Schwartzberg, L.S.2
Danso, M.A.3
-
35
-
-
79551649114
-
Basal-like and triple-negative breast cancers: A critical review with an emphasis on the implications for pathologists and oncologists
-
Badve S, Dabbs DJ, Schnitt SJ, et al. Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol. 2011;24:157-67.
-
(2011)
Mod Pathol
, vol.24
, pp. 157-167
-
-
Badve, S.1
Dabbs, D.J.2
Schnitt, S.J.3
-
36
-
-
84857092267
-
Pharmacodynamic and pathway analysis of three presumed inhibitors of poly (ADP-ribose) polymerase: ABT-888, AZD 2281, and BSI201
-
Apr 2-6; Orlando, Fla. AACR. 2011. Abstract nr 4527
-
Ji J, Lee MP, Kadota M, et al Pharmacodynamic and pathway analysis of three presumed inhibitors of poly (ADP-ribose) polymerase: ABT-888, AZD 2281, and BSI201. Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, Fla. AACR. 2011. Abstract nr 4527).
-
(2011)
Proceedings of the 102nd Annual Meeting of the American Association For Cancer Research
-
-
Ji, J.1
Lee, M.P.2
Kadota, M.3
-
37
-
-
80355129138
-
All PARP inhibitors are not equal: An in vitro mechanistic comparison of PF-01367338 to iniparib
-
(abstr e13576)
-
Maegley KA, Bingham P, Tatlock JH, et al. All PARP inhibitors are not equal: an in vitro mechanistic comparison of PF-01367338 to iniparib. J Clin Oncol. 2011;29 (suppl; abstr e13576).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Maegley, K.A.1
Bingham, P.2
Tatlock, J.H.3
-
38
-
-
80355136309
-
Functional analysis of PARP inhibitors AZD 2281 and BSI-201 in human tumor primary cultures: A comparison of activity and examination of synergy with cytotoxic drugs
-
(abstr e13599)
-
Nagourney RA, Kenyon KR, Francisco FR, et al. Functional analysis of PARP inhibitors AZD 2281 and BSI-201 in human tumor primary cultures: a comparison of activity and examination of synergy with cytotoxic drugs. J Clin Oncol. 2011;29 (suppl; abstr e13599).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Nagourney, R.A.1
Kenyon, K.R.2
Francisco, F.R.3
-
39
-
-
52449111109
-
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin
-
Evers B, Drost R, Schut E, et al. Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin. Clin Cancer Res. 2008; 14:3916-3925.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3916-3925
-
-
Evers, B.1
Drost, R.2
Schut, E.3
-
40
-
-
55949092708
-
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
-
Rottenberg S, Jaspers JE, Kersbergen A, et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci USA. 2008;105:17079-17084.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17079-17084
-
-
Rottenberg, S.1
Jaspers, J.E.2
Kersbergen, A.3
-
41
-
-
34147182310
-
Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial
-
Thomas HD, Calabrese CR, Batey MA, et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther. 2007;6:945-956.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 945-956
-
-
Thomas, H.D.1
Calabrese, C.R.2
Batey, M.A.3
-
42
-
-
34249006299
-
ABT-888, an orally active poly(ADPribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
-
Donawho CK, Luo Y, Penning TD, et al. ABT-888, an orally active poly(ADPribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007;13:2728-2737.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2728-2737
-
-
Donawho, C.K.1
Luo, Y.2
Penning, T.D.3
-
43
-
-
77955856734
-
Safety and efficacy of the oral PARP inhibitor olaparib (AZD2281) in combination with paclitaxel for the first- or second-line treatment of patients with metastatic triple-negative breast cancer: Results from the safety cohort of a phase I/II multicenter trial
-
abstr 1018
-
Dent RA, Lindeman GJ, Clemons M, et al. Safety and efficacy of the oral PARP inhibitor olaparib (AZD2281) in combination with paclitaxel for the first- or second-line treatment of patients with metastatic triple-negative breast cancer: results from the safety cohort of a phase I/II multicenter trial. J Clin Oncol. 2010;28:15s (suppl; abstr 1018).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
, pp. 28
-
-
Dent, R.A.1
Lindeman, G.J.2
Clemons, M.3
-
44
-
-
80355139266
-
Phase I trial of veliparib, (ABT-888), a poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with doxorubicin and cyclophosphamide in breast cancer and other solid tumors
-
abstr 3041)
-
Tan AR, Toppmeyer D, Stein MN, et al. Phase I trial of veliparib, (ABT-888), a poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with doxorubicin and cyclophosphamide in breast cancer and other solid tumors. J Clin Oncol. 2011;29 (suppl; abstr 3041).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Tan, A.R.1
Toppmeyer, D.2
Stein, M.N.3
-
45
-
-
79956209286
-
A phase I study of ABT-888 (A) in combination with metronomic cyclophosphamide (C) in adults with refractory solid tumors and lymphomas
-
abstr 2605)
-
Kummar S, Chen AP, Ji JJ, et al. A phase I study of ABT-888 (A) in combination with metronomic cyclophosphamide (C) in adults with refractory solid tumors and lymphomas. J Clin Oncol. 2010;28:15s (suppl; abstr 2605).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Kummar, S.1
Chen, A.P.2
Ji, J.J.3
-
46
-
-
77956300908
-
Preliminary results of a phase I trial of ABT-888, a poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with cyclophosphamide
-
abstr 3000)
-
Tan AR, Gibbon D, Stein MN. Preliminary results of a phase I trial of ABT-888, a poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with cyclophosphamide. J Clin Oncol. 2010;28:15s (suppl; abstr 3000).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
, pp. 28
-
-
Tan, A.R.1
Gibbon, D.2
Stein, M.N.3
-
47
-
-
77955877185
-
A phase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer
-
abstr 1019)
-
Isakoff SJ, Overmoyer B, Tung NM, et al. A phase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer. J Clin Oncol. 2010;28:15s (suppl; abstr 1019).
-
(2010)
J Clin Oncol
, vol.15 s
, Issue.SUPPL.
, pp. 28
-
-
Isakoff, S.J.1
Overmoyer, B.2
Tung, N.M.3
-
48
-
-
79551652531
-
The clinical development of inhibitors of poly(ADP-ribose) polymerase
-
Calvert H, Azzariti A. The clinical development of inhibitors of poly(ADP-ribose) polymerase. Ann Oncol. 2011;22(Suppl):i53-159.
-
(2011)
Ann Oncol
, vol.22
, Issue.SUPPL.
-
-
Calvert, H.1
Azzariti, A.2
-
49
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
Edwards SL, Brough R, Lord CJ, et al. Resistance to therapy caused by intragenic deletion in BRCA2. Nature. 2008;451:1111-1115.
-
(2008)
Nature
, vol.451
, pp. 1111-1115
-
-
Edwards, S.L.1
Brough, R.2
Lord, C.J.3
-
50
-
-
77950958141
-
53BP1 inhibits homologous recombination in BRCA1-deficient cells by blocking resection of DNA breaks
-
Bunting SF, Callen E, Wong N, et al. 53BP1 inhibits homologous recombination in BRCA1-deficient cells by blocking resection of DNA breaks. Cell. 2010;141:243-254.
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
Callen, E.2
Wong, N.3
-
51
-
-
79952747328
-
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
-
Patel AG, Sarkaria JN, Kaufmann SH. Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc Natl Acad Sci. 2011;108:3406-3411.
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 3406-3411
-
-
Patel, A.G.1
Sarkaria, J.N.2
Kaufmann, S.H.3
-
52
-
-
80355145583
-
A phase I trial of the PARP inhibitor olaparib (AZD2281) in combination with the antiangiogenic cediranib (AZD2171) in recurrent ovarian or triple-negative breast cancer
-
abstr 5028
-
Liu J, Fleming GF, Tolaney SM, et al. A phase I trial of the PARP inhibitor olaparib (AZD2281) in combination with the antiangiogenic cediranib (AZD2171) in recurrent ovarian or triple-negative breast cancer. J Clin Oncol. 2011;29 (suppl; abstr 5028).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Liu, J.1
Fleming, G.F.2
Tolaney, S.M.3
-
53
-
-
80355136310
-
Phase I study of the PARP inhibitor olaparib (O) in combination with carboplatin (C) in BRCA1/2 mutation carriers with breast (Br) or ovarian (Ov) cancer (Ca)
-
abstr 2520
-
Lee J, Annunziata CM, Minasian LM, et al. Phase I study of the PARP inhibitor olaparib (O) in combination with carboplatin (C) in BRCA1/2 mutation carriers with breast (Br) or ovarian (Ov) cancer (Ca). J Clin Oncol. 2011;29(suppl; abstr 2520).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Lee, J.1
Annunziata, C.M.2
Minasian, L.M.3
et al4
-
54
-
-
80355136311
-
A phase 1B study to assess the safety and tolerability of the PARP inhibitor iniparib (BSI-201) in combination with irinotecan for the treatment of patients with metastatic breast cancer (MBC)
-
[P6-15-01]. Abstract nr P6-15-01
-
Moulder S, Mita M, Bradley C, et al. [P6-15-01]. A phase 1B study to assess the safety and tolerability of the PARP inhibitor iniparib (BSI-201) in combination with irinotecan for the treatment of patients with metastatic breast cancer (MBC). Cancer Res. 2010;70(24 Suppl):Abstract nr P6-15-01.
-
(2010)
Cancer Res
, vol.70
, Issue.24 SUPPL.
-
-
Moulder, S.1
Mita, M.2
Bradley, C.3
-
55
-
-
80355136313
-
Phase II trial of the poly(ADP-ribose) polymerase (PARP) inhibitor AG-014699 in BRCA 1 and 2mutated, advanced ovarian and/or locally advanced or metastatic breast cancer
-
abstr 3104
-
Drew Y, Ledermann JA, Jones A, et al. Phase II trial of the poly(ADP-ribose) polymerase (PARP) inhibitor AG-014699 in BRCA 1 and 2mutated, advanced ovarian and/or locally advanced or metastatic breast cancer. J Clin Oncol. 2011;29(suppl; abstr 3104).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Drew, Y.1
Ledermann, J.A.2
Jones, A.3
|