Serotonin Conflict in Sleep-Feeding

Vitamins and Hormones

Volumn 89, Issue , 2012, Pages 223-239

  Nonogaki, Katsunori ^a  

^a TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

5 HT receptor; Feeding; GLP 1; POMC; Sleep

Indexed keywords

EID: 84861466389     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394623-2.00012-3     Document Type: Chapter

References (90)

1. Al-Shamma H.A., Anderson C., Chuang E., Luthringer R., Grottick A.J., Hauser E., Morgan M., Shanahan W., Teegarden B.R., Thomsen W.J., Behan D. Nelotanserin, a novel selective human 5-hydroxytryptamine 2A inverse agonist for the treatment of insomnia. J. Pharmacol. Exp. Ther. 2010, 332:281-290.
2. Asarian L. Loss of cholecystokinin and glucagon-like peptide-1-induced satiation in mice lacking serotonin 2C receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 296:51-56.
3. Aslan S., Isik E., Cosar B. The effects of mirtazapine on sleep: A placebo controlled, double-blind study in young healthy volunteers. Sleep 2002, 25:677-679.
4. Barnes N.M., Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999, 38:1083-1152.
5. Baxter G., Kennett G., Blaney F., Blackburn T. 5-HT2 receptor subtypes: A family re-united?. Trends Pharmacol. Sci. 1995, 16:105-110.
6. Bjorvatn B., Ursin R. Effects of the selective 5-HT1B agonist, CGS 12066B, on sleep/waking stages and EEG power spectrum in rats. J. Sleep Res. 1994, 3:97-105.
7. Boutrel B., Franc B., Hen R., Hamon M., Adrien J. Key role of 5-HT1B receptors in the regulation of paradoxical sleep as evidenced in 5-HT1B knock-out mice. J. Neurosci. 1999, 19:3204-3212.
8. Boutrel B., Monaca C., Hen R., Hamon M., Adrien J. Involvement of 5-HT1A receptors in homeostatic and stress-induced adaptive regulations of paradoxical sleep: Studies in 5-HT1A knock-out mice. J. Neurosci. 2002, 22:4686-4692.
9. Bouwknecht J.A., van der Gugten J., Hijzen T.H., Maes R.A., Hen R., Olivier B. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiol. Behav. 2001, 74:507-516.
10. Bruinvels A.T., Landwehrmeyer B., Gustafson E.L., Durkin M.M., Mengod G., Branchek T.A., Hoyer D., Palacios J.M. Localization of 5-HT1B, 5-HT1D alpha, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain. Neuropharmacology 1994, 33:367-386.
11. Cappuccio F.P., Taggart F.M., Kandala N.B., Currie A., Peile E., Stranges S., Miller M.A. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 2008, 31:619-626.
12. Conn P.J., Sanders-Bush E., Hoffman B.J., Hartig P.R. A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc. Natl. Acad. Sci. U.S.A. 1986, 83:4086-4088.
13. Cowley M.A., Smart J.L., Rubinstein M., Cerdán M.G., Diano S., Horvath T.L., Cone R.D., Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001, 411:480-484.
14. Fink K.B., Göthert M. 5-HT receptor regulation of neurotransmitter release. Pharmacol. Rev. 2007, 59:360-417.
15. Fletcher P.J., Tampakeras M., Sinyard J., Slassi A., Isaac M., Higgins G.A. Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. Neuropharmacology 2009, 57:259-267.
16. Frank M.G., Stryker M.P., Tecott L.H. Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor. Neuropsychopharmacology 2002, 27:869-873.
17. Friedman J.M. Modern science versus the stigma of obesity. Nat. Med. 2004, 10:563-569.
18. Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
19. Halford J.C., Blundell J.E. The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. Physiol. Behav. 1996, 60:933-939.
20. Hedlund P.B., Sutcliffe J.G. Functional, molecular and pharmacological advances in 5-HT7 receptor research. Trends Pharmacol. Sci. 2004, 25:481-486.
21. Hedlund P.B., Huitron-Resendiz S., Henriksen S.J., Sutcliffe J.G. 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern. Biol. Psychiatry 2005, 58:831-837.
22. Heisler L.K., Cowley M.A., Tecott L.H., Fan W., Low M.J., Smart J.L., Rubinstein M., Tatro J.B., Marcus J.N., Holstege H., Lee C.E., Cone R.D., et al. Activation of central melanocortin pathways by fenfluramine. Science 2002, 297:609-611.
23. Heisler L.K., Jobst E.E., Sutton G.M., Zhou L., Borok E., Thornton-Jones Z., Liu H.Y., Zigman J.M., Balthasar N., Kishi T., Lee C.E., Aschkenasi C.J., et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 2006, 51:239-249.
24. Hoffman B.J., Mezey E. Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain. FEBS Lett. 1989, 247:453-462.
25. Holst J.J. The physiology of glucagon-like peptide 1. Physiol. Rev. 2007, 87:1409-1439.
26. Horne J. Obesity and short sleep: Unlikely bedfellows?. Obes. Rev. 2011, 12:84-94.
27. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol. Rev. 1994, 46:157-203.
28. Hutson P.H., Donohoe T.P., Curzon G. Infusion of the 5-hydroxytryptamine agonists RU24969 and TFMPP into the paraventricular nucleus of the hypothalamus causes hypophagia. Psychopharmacology (Berl.) 1988, 95:550-552.
29. Julius D., MacDermott A.B., Axel R., Jessell T.M. Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 1988, 241:558-564.
30. Katsuda Y., Walsh A.E.S., Ware C.J., Cowen P.J., Sharpley A.L. meta-Chlorophenylpiperazine decrease slow wave sleep in humans. Biol. Psychiatry 1993, 33:49-51.
31. Laposky A.D., Shelton J., Bass J., Dugovic C., Perrino N., Turek F.W. Altered sleep regulation in leptin-deficient mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R894-R903.
32. Laposky A.D., Bradley M.A., Williams D.L., Bass J., Turek F.W. Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008, 295:R2059-R2066.
33. Lee M.D., Simansky K.J. CP-94, 253: A selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology 1997, 131:264-270.
34. Lee M.D., Somerville E.M., Kennett G.A., Dourish C.T., Clifton P.G. Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Psychopharmacology 2004, 176:39-49.
35. Leibowitz S.F., Weiss G.F., Suh J.S. Medial hypothalamic nuclei mediate serotonin's inhibitory effect on feeding behavior. Pharmacol. Biochem. Behav. 1990, 37:735-742.
36. Lovshin J.A., Drucker D.J. Incretin-based therapies for type 2 diabetes mellitus. Nat. Rev. Endocrinol. 2009, 5:262-269.
37. Lucas J.J., Yamamoto A., Scearce-Levie K., Saudou F., Hen R. Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice. J. Neurosci. 1998, 18:5537-5544.
38. Martin J.R., Bös M., Jenck F., Moreau J., Mutel V., Sleight A.J., Wichmann J., Andrews J.S., Berendsen H.H., Broekkamp C.L., Ruigt G.S., Köhler C., et al. 5-HT2C receptor agonists: Pharmacological characteristics and therapeutic potential. J. Pharmacol. Exp. Ther. 1998, 286:913-924.
39. Monti J.M. The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep. Sleep Med. Rev. 2010, 14:319-327.
40. Monti J.M. Serotonin control of sleep-wake behavior. Sleep Med. Rev. 2011, 15:269-281.
41. Monti J.M., Jantos H. Differential effects of the 5-HT1A receptor agonist flesinoxan given locally or systemically on REM sleep in the rat. Eur. J. Pharmacol. 2003, 478:121-130.
42. Monti J.M., Jantos H. Effects of the 5-HT1A receptor antagonists SB-399885 and RO-4368554 and of the 5-HT(2A) receptor antagonist EMD 281014 on sleep and wakefulness in the rat during both phases of the light-dark cycle. Behav. Brain Res. 2011, 216:381-388.
43. Monti J.M., Jantos H., Silveira R., Reyes-Parada M., Scorza C., Prunell G. Depletion of brain serotonin by 5,7-DHT: Effects on the 8-OH-DPAT-induced changes of sleep and waking in the rat. Psychopharmacology 1994, 115:273-277.
44. Monti J.M., Monti D., Jantos H., Ponzoni A. Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat. Neuropharmacology 1995, 34:1647-1651.
45. Morairty S.R., Hedley L., Flores J., Martin R., Kilduff T.S. Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats. Sleep 2008, 31:34-44.
46. Mozaffarian D., Hao T., Rimm E.B., Willett W.C., Hu F.B. Changes in diet and lifestyle and long-term weight gain in women and men. N. Engl. J. Med. 2011, 364:2392-2404.
47. Nonogaki K. 5-HT and NA reuptake inhibitors and appetite regulation: The role of the central 5-HT network. Immun. Endocr. Metab. Agents Med. Chem. 2008, 8:303-310.
48. Nonogaki K., Kaji T. Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice. Int. J. Neuropsychopharmacol. 2010, 13:1261-1267.
49. Nonogaki K., Strack A.M., Dallman M.F., Tecott L.H. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat. Med. 1998, 4:1152-1156.
50. Nonogaki K., Abdallah L., Goulding E.H., Bonasera S.J., Tecott L.H. Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice. Diabetes 2003, 52:315-320.
51. y mice. Endocrinology 2006, 147:5893-5900.
52. y mice. Biochem. Biophys. Res. Commun. 2006, 351:1078-1082.
53. Nonogaki K., Nozue K., Oka Y. Social isolation affects the development of obesity and type 2 diabetes in mice. Endocrinology 2007, 148:4658-4666.
54. Nonogaki K., Nozue K., Takahashi Y., Yamashita N., Hiraoka S., Kumano H., Kuboki T., Oka Y. Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors. Int. J. Neuropsychopharmacol. 2007, 10:675-681.
55. Nonogaki K., Ohba Y., Sumii M., Oka Y. Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice. Biochem. Biophys. Res. Commun. 2008, 372:186-190.
56. Nonogaki K., Ohba Y., Wakameda M., Tamari T. Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene. Int. J. Neuropsychopharmacol. 2009, 12:547-552.
57. Nonogaki K., Suzuki M., Sanuki M., Wakameda M., Tamari T. The contribution of serotonin 5-HT2C and melanocortin-4 receptors to the satiety signaling of glucagon-like peptide 1 and liragultide, a glucagon-like peptide 1 receptor agonist, in mice. Biochem. Biophys. Res. Commun. 2011, 29(411):445-448.
58. Ohno K., Sakurai T. Orexin neuronal circuitry: Role in the regulation of sleep and wakefulness. Front. Neuroendocrinol. 2008, 29:70-87.
59. Opp M.R., Obál F., Krueger J.M. Effects of alpha-MSH on sleep, behavior, and brain temperature: Interactions with IL 1. Am. J. Physiol. 1988, 255:R914-R922.
60. Paez X., Leibowitz S.F. Changes in extracellular PVN monoamines and macronutrient intake after idazoxan or fluoxetine injection. Pharmacol. Biochem. Behav. 1993, 46:933-941.
61. Pasqualetti M., Ori M., Castagna M., Marazziti D., Cassano G.B., Nardi I. Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain. Neuroscience 1999, 92:601-611.
62. Patel S.R., Hu F.B. Short sleep duration and weight gain: A systematic review. Obesity 2008, 16:643-653.
63. Petrov T., Krukoff T.L., Jhamandas J.H. The hypothalamic paraventricular and lateral parabrachial nuclei receive collaterals from raphe nucleus neurons: A combined double retrograde and immunocytochemical study. J. Comp. Neurol. 1992, 318:18-26.
64. Popa D., Léna C., Fabre V., Prenat C., Gingrich J., Escourrou P., Hamon M., Adrien J. Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors. J. Neurosci. 2005, 25:11231-11238.
65. Portas C.M., Bjorvatn B., Ursin R. Serotonin and the sleep/wake cycle: Special emphasis on microdialysis studies. Prog. Neurobiol. 2000, 60:13-35.
66. Roberts J.C., Reavill C., East S.Z., Harrison P.J., Patel S., Routledge C., Leslie R.A. The distribution of 5-HT(6) receptors in rat brain: An autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist [(125)I]SB-258585. Brain Res. 2002, 934:49-57.
67. Ruat M., Traiffort E., Arrang J.M., Tardivel-Lacombe J., Diaz J., Leurs R., Schwartz J.C. A novel rat serotonin (5-HT6) receptor: Molecular cloning, localization and stimulation of cAMP accumulation. Biochem. Biophys. Res. Commun. 1993, 193:268-276.
68. Sakurai T., Mieda M. Connectomics of orexin-producing neurons: Interface of systems of emotion, energy homeostasis and arousal. Trends Pharmacol. Sci. 2011, 32:451-462.
69. Saper C.B., Loewy A.D. Efferent connections of the parabrachial nucleus in the rat. Brain Res. 1980, 197:291-317.
70. Schmid S.M., Hallschmid M., Jauch-Chara K., Born J., Schultes B. A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men. J. Sleep Res. 2008, 17:331-334.
71. Schwartz D., Hernandez L., Hoebel B.G. Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis. Brain Res. 1989, 482:261-270.
72. Sehgal A., Mignot E. Genetics of sleep and sleep disorders. Cell 2011, 146:194-207.
73. Sharpley A.L., Vassallo C.M., Cowen P.J. Olanzapine increases slow-wave sleep: Evidence for blockade of central 5-HT2C receptors in vivo. Biol. Psychiatry 2000, 47:468-470.
74. Shor-Posner G., Grinker J.A., Marinescu C., Brown O., Leibowitz S.F. Hypothalamic serotonin in the control of meal patterns and macronutrient selection. Brain Res. Bull. 1986, 17:663-671.
75. Smith M.I., Piper D.C., Duxon M.S., Upton N. Effect of SB-243213, a selective 5-HT2C receptor antagonist, on the rat sleep profile: A comparison to paroxetine. Pharmacol. Biochem. Behav. 2002, 71:599-605.
76. Solomon R.A., Sharpley A.L., Cowen P.J. Increased slow wave sleep with 5-HT2 receptor antagonists: Detection by ambulatory EEG recording and automatic sleep stage analysis. J. Psychopharmacol. 1989, 3:125-129.
77. Sørensen E., Grønli J., Bjorvatn B., Ursin R. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep-waking and behavioural effects of 8-OH-DPAT in rats. Behav. Brain Res. 2001, 121:181-187.
78. Spiegel K., Tasali E., Penev P., Van Cauter E. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann. Intern. Med. 2004, 141:846-850.
79. Spiegel K., Tasali E., Leproult R., Van Cauter E. Effects of poor and short sleep on glucose metabolism and obesity risk. Nat. Rev. Endocrinol. 2009, 5:253-261.
80. Steinbusch H.W., Nieuwenhuys R. Localization of serotonin-like immunoreactivity in the central nervous system and pituitary of the rat, with special references to the innervation of the hypothalamus. Adv. Exp. Med. Biol. 1981, 133:7-35.
81. St-Onge M.P., Roberts A.L., Chen J., Kelleman M., O'Keeffe M., Roychoudhury A., Jones P.J. Short sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals. Am. J. Clin. Nutr. 2011, 94:410-416.
82. Stricker-Krongrad A., Richy S., Beck B. Orexins/hypocretins in the ob/ob mouse: Hypothalamic gene expression, peptide content and metabolic effects. Regul. Pept. 2002, 104:11-20.
83. Tecott L.H. Serotonin and the orchestration of energy balance. Cell Metab. 2007, 6:352-361.
84. Thomsen W.J., Grottick A.J., Menzaghi F., Reyes-Saldana H., Espitia S., Yuskin D., Whelan K., Martin M., Morgan M., Chen W., Al-Shamma H., Smith B., et al. Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: In vitro and in vivo pharmacological characterization. J. Pharmacol. Exp. Ther. 2008, 325:577-587.
85. Tsujino N., Sakurai T. Orexin/hypocretin: A neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol. Rev. 2009, 61:162-176.
86. Woolley M.L., Marsden C.A., Fone K.C. 5-HT6 receptors. Curr. Drug Targets CNS Neurol. Disord. 2004, 3:59-79.
87. Wright D.E., Seroogy K.B., Lundgren K.H., Davis B.M., Jennes L. Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol. 1995, 351:357-373.
88. Xu Y., Jones J.E., Kohno D., Williams K.W., Lee C.E., Choi M.J., Anderson J.G., Heisler L.K., Zigman J.M., Lowell B.B., Elmquist J.K. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 2008, 60:582-589.
89. Yagaloff K.A., Hartig P.R. 125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells. J. Neurosci. 1985, 5:3178-3183.
90. Yamamoto Y., Ueta Y., Date Y., Nakazato M., Hara Y., Serino R., Nomura M., Shibuya I., Matsukura S., Yamashita H. Down regulation of the prepro-orexin gene expression in genetically obese mice. Brain Res. Mol. Brain Res. 1999, 65:14-22.