Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice

Psychopharmacology

Volumn 176, Issue 1, 2004, Pages 39-49

  Lee, Michelle D ^a,b   Somerville, Elizabeth M ^a   Kennett, Guy A ^c   Dourish, Colin T ^c   Clifton, Peter G ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

^c Vernalis PLC   (United Kingdom)

Author keywords

5 HT; 5 HT1B knockout mouse; 5 HT2C receptors; 5 hydroxytryptamine; Adaptive change; d Fenfluramine; Quantitative autoradiography; Serotonin

Indexed keywords

2,3,6,7 TETRAHYDRO 1' METHYL 5 [[2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL) 4 BIPHENYLYL]CARBONYL]SPIRO[FURO[2,3 F]INDOLE 3,4' PIPERIDINE]; DEXFENFLURAMINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SEROTONIN 1C RECEPTOR; SEROTONIN 2C AGONIST;

ARTICLE; ATTENUATION; BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; EVALUATION; HYPOPHAGIA; KNOCKOUT MOUSE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REDUCTION; REPRODUCIBILITY; SATIETY; WILD TYPE;

ANIMALS; BINDING SITES; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; EATING; ERGOLINES; FENFLURAMINE; GENOTYPE; GREAT BRITAIN; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; ISOMERISM; MIANSERIN; MICE; MICE, KNOCKOUT; PIPERAZINES; PIPERIDONES; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; SATIATION; SATIETY RESPONSE; SPECIES SPECIFICITY; SPIPERONE; SPIRO COMPOUNDS; TIME FACTORS; TRITIUM;

EID: 8644255831     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-004-1864-0     Document Type: Article

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