Effect of SB-243213, a selective 5-HT2C receptor antagonist, on the rat sleep profile: A comparison to paroxetine

Pharmacology Biochemistry and Behavior

Volumn 71, Issue 4, 2002, Pages 599-605

  Smith, M I ^a   Piper, D C ^a   Duxon, M S ^a   Upton, N ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT2C receptors; 5 Hydroxytryptamine; Antagonist; Depression; Paroxetine; SB 243213 A; Selective serotonin reuptake inhibitor; Sleep

Indexed keywords

5 METHYL 1 [[ 2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL] 6 TRIFLUOROMETHYLINDOLINE; 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL] 6 TRIFLUOROMETHYLINDOLINE; PAROXETINE; SEROTONIN 2C ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANXIETY NEUROSIS; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP; SLEEP PATTERN; SLEEP TIME; SLOW WAVE SLEEP;

ANIMALS; AROUSAL; ELECTROENCEPHALOGRAPHY; INDOLES; MALE; PAROXETINE; POLYSOMNOGRAPHY; PYRIDINES; RATS; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SLEEP; SLEEP STAGES;

OXY;

EID: 0036122396     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(01)00702-X     Document Type: Article

References (50)

1. 2C receptor protein in human and rat brain using specific antisera
2. In vivo brain dialysis study of the somatodendritic release of serotonin in the raphé nuclei of the rat: Effects of 8-hydroxy-2-(di-n-propylamino)tetralin
3. A review of central 5-HT receptors and their function
4. 2 receptor binding on blood platelets as a state dependent marker in major affective disorder
5. 2C receptor inverse agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5pyridyl]carbamoyl]-6- trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent
6. 2C receptor protein in the rat CNS
7. Increase in slow wave sleep in humans with the serotonin-S2 antagonist ritanserin
8. Sleep deprivation therapy in depressive illness and Parkinsons disease
9. 1C agonist m-chlorophenylpiperazine in the rat
10. 2 receptors could be primarily involved in the regulation of slow-wave sleep in the rat
11. 1A receptor antagonist WAY100635
12. 2C receptor levels in the rat
13. Age-related changes in sleep in depressed and normal subjects
14. Role of 5-HT in stress, anxiety, and depression
15. Effect of selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: Microdialysis studies using paroxetine
16. Sleep disturbances in depressive syndromes
17. The neuropsychology of REM sleep dreaming
18. 1C receptors
19. Proposed new nomenclature for 5-HT receptors
20. 5-Hydroxytryptamine-2 antagonist increases human slow wave sleep
21. Different effect of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in the rat brain
22. 2C, receptor antagonist
23. The organisation and regulation of sleep
24. Critical analysis of the theories advanced to explain short REM sleep latencies and other sleep anomalies in several psychiatric conditions
25. Receptor-binding properties in vitro and in vivo of ritanserin
26. Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with serotoni-S2 receptor antagonists
27. Anxiolytic-like effect of paroxetine in a rat social interaction test
28. Serotonin neurons and sleep: I. Long term recordings of dorsal raphé discharge frequency and PGO waves
29. Serotonin neurons and sleep: II. Time course of dorsal raphé discharge, PGO waves, and behavioral states
30. The serotin hypothesis of major depression
31. Increased serotonin2 and beta-adrenergic receptor binding in the frontal cortices of suicide victims
32. 5-HT receptor binding in post-mortem brain from patients with affective disorder
33. Psychopathology and sleep-III-depression
34. Pharmacological effects of paroxetine after repeat administration to animals
35. Long-term antidepressant treatment decreases spiroperidol-labelled serotonin receptor binding
36. The novel brain neuropeptide, orexin-a, modulates the sleep-wake cycle of rats
37. Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphé nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat
38. How to preserve the antidepressant effect of sleep deprivation: A comparison of sleep phase delay
39. Conventional and spectral power analysis of all night sleep EEG after subchronic treatment with paroxetine in healthy male volunteers
40. 2 receptor antagonists on slow wave sleep in humans
41. 2C receptors
42. 2 receptor antagonism and slow wave sleep in major depression
43. Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: A double-blind randomized trial in major depression
44. 3H]spiperone binding in rat frontal cortex and serotonin receptor mediated behaviour
45. Depression, sleep and antidepressants
46. Antidepressant treatment of the depressed patient with insomnia
47. Effects of fluoxetine on the polysomnogram in outpatients with major depression
48. 2C receptor inverse agonist with improved anxiolytic profile: Lack of tolerance and withdrawal anxiety
49. 2 agonist, DOI on 5-HT neuronal firing in the dorsal raphé nucleus and 5-HT realease and metabolism in the frontal cortex
50. 2 changes in major depression