Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of -endorphin gene

International Journal of Neuropsychopharmacology

Volumn 12, Issue 4, 2009, Pages 547-552

  Nonogaki, Katsunori ^a,b   Ohba, Yukie ^a   Wakameda, Mamoru ^c   Tamari, Tomohiro ^c  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

endorphin; 5 HT2C receptor; Fluvoxamine; Food intake; MCPP

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; BETA ENDORPHIN; FLUVOXAMINE; PROOPIOMELANOCORTIN; SEROTONIN 2C RECEPTOR; 1-(3-CHLOROPHENYL)PIPERAZINE; ANOREXIGENIC AGENT; ANTIDEPRESSANT AGENT; PIPERAZINE DERIVATIVE; SEROTONIN AGONIST;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; GENE MUTATION; HETEROZYGOSITY; HYPOTHALAMUS; MALE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; EATING; GENETICS; METABOLISM; MOUSE MUTANT; MUTATION;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; APPETITE DEPRESSANTS; BETA-ENDORPHIN; EATING; FLUVOXAMINE; HYPOTHALAMUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; PIPERAZINES; PRO-OPIOMELANOCORTIN; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN AGONISTS;

EID: 67649208320     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145708009619     Document Type: Article

References (21)

1. Appleyard SM, Hayward M, Young J, Butler AA, Cone RD, Rubinstein M, Low MJ (2003). A role for the endogenous opioid b-endorphin in energy homeostasis. Endocrinology 144, 1753-1760.
2. Ayuso-Gutierrez JL, Palazon M, Ayuso-Mateos JL (1994). Open trial of fluvoxamine in the treatment of bulimia nervosa. International Journal of Eating Disorders 15, 245-249.
3. Dalton GL, Lee MD, Kennet GA, Dourish CT, Clifton PG (2006). Serotonin 1B and 2C receptor interactions in the modulation of feeding behavior in the mouse. Psychopharmacology 185, 45-57.
4. Fichter MM, Kruger R, Rief W, Holland R, Dohne J (1996). Fluvoxamine in prevention of relapse in bulimia nervosa: effects on eating-specific psychopathology. Journal of Clinical Psychopharmacology 16, 9-18.
5. Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, et al. (2002). Activation of central melanocortin pathways by fenfluramine, Science 297, 609-611.
6. Hewitt KN, Lee MD, Dourish CT, Clifton PG (2002). Serotonin 2C receptor agonists and the behavioural satiety sequence in mice. Pharmacology Biochemistry and Behavior 71, 691-700.
7. Hudson JI, McElroy SL, Raymond NC, Crow Jr. S, Keck PE, Carter WP, Mitchell JE, Strakoski Jr. SM, Pope HG, Coleman BS, Jonas JM (1998). Fluvoxamine in the treatment of binge-eating disorder: a multicenter placebo-controlled, double-blind trial. American Journal of Psychiatry 155, 1756-1762.
8. Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly RS, Heisler LK (2007). Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. Endocrinology 149, 1323-1328.
9. Lee MD, Somerville EM, Kennett GA, Dourish CT, Clifton PG (2004). Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Psychopharmacology 176, 39-49.
10. Lucas JJ, Yamamoto A, Scearce-Levie K, Saudou F, Hen R (1998). Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice. Journal of Neuroscience 18, 5537-5544.
11. Nonogaki K, Strack AM, Dallman MF, Tecott LH (1998). Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nature Medicine 4, 1152-1156.
12. Nonogaki K, Nozue K, Oka Y (2006a). Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice. Endocrinology 145, 5893-5900.
13. Nonogaki K, Ohashi-Nozue K, Oka Y (2006b). A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice. Biochemical and Biophysical Research Communications 341, 703-707.
14. 1B receptors. International Journal of Neuropsyhcopharmacology 10, 675-681.
15. Nonogaki K, Nozue K, Kuboki T, Oka Y (2007b). Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 292, R1775-1781.
16. Nonogaki K, Ohba Y, Sumii M, Oka Y (2008). Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independentpathway in mice. Biochemical and Biophysical Research Communications 372, 186-190.
17. Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K, et al. (2006). Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 443, 709-712.
18. Rubinstein M, Mogil JS, Japon M, Chan EC, Allen RG, Low MJ (1996). Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site directed mutagenesis. Proceedings of the National Academy of Sciences USA 93, 3995-4000.
19. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D (1995). Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors. Nature 374, 542-546.
20. Vickers SP, Clifton PG, Dourish CT, Tecott LH (1999). Reduced satiating effect of D-fenfluramine in serotonin 5-HT(2C) receptor mutant mice. Psychopharmacology 143, 309-314.
21. Vickers SP, Dourish CT, Kennett GA (2001). Evidence that hypophagia induced by D-fenfluramine and D-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology 41, 200-209.