Iron metabolism and tools for the iron status assessment;Métabolisme du fer et outils diagnostiques pour le clinicien

Revue de Medecine Interne

Volumn 33, Issue SUPPL. 1, 2012, Pages

  Loreal O ^a,b   Bardou Jacquet, E ^a,b   Jouanolle, A M ^b   Gandon, Y ^a,b   Deugnier, Y ^a,b   Brissot, P ^a,b   Ropert, M ^a,b  

^a UNIVERSITÉ DE RENNES 1   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

Anaemia; Ferroportin; Genes; Genetic; Hemochromatosis; Hepcidin; Iron metabolism

Indexed keywords

ARTICLE; CLINICAL ASSESSMENT; HEALTH STATUS; IRON METABOLISM;

BLOOD CHEMICAL ANALYSIS; DIAGNOSTIC TECHNIQUES AND PROCEDURES; HEALTH STATUS; HEMATOLOGY; HUMANS; INTERNAL MEDICINE; IRON METABOLISM DISORDERS; IRON, DIETARY; MODELS, BIOLOGICAL;

EID: 84861223277     PISSN: 02488663     EISSN: 17683122     Source Type: Journal    
DOI: 10.1016/j.revmed.2012.03.005     Document Type: Article

References (38)

1. Andrews N.C. Disorders of iron metabolism [published erratum appears in N Engl J Med 2000 Feb 3;342(5):364]. N Engl J Med 1999, 341(26):1986-1995.
2. Crichton R. Iron and oxidative stress. Inorganic biochemistry of iron metabolism: from molecular mechanisms to clinical consequences 2001, John Wiley and Sons, Ltd, Chichester, p. 235-57.
3. McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 2000, 5(2):299-309.
4. Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S.J., Moynihan J., et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter [see comments]. Nature 2000, 403(6771):776-781.
5. Osaki S., Johnson D.A., Frieden E. The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem 1966, 241:2746-2751.
6. Mukhopadhyay C.K., Attieh Z.K., Fox P.L. Role of ceruloplasmin in cellular iron uptake. Science 1998, 279(5351):714-717.
7. Anderson G.J., Frazer D.M., McKie A.T., Vulpe C.D., Smith A. Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism. Biometals 2005, 18(4):339-348.
8. Loréal O., Haziza-Pigeon C., Troadec M.B., Detivaud L., Turlin B., Courselaud B., et al. Hepcidin in iron metabolism. Curr Protein Pept Sci 2005, 6(3):279-291.
9. Ganz T. Hepcidin and iron regulation, 10 years later. Blood 2011, 117(17):4425-4433.
10. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306(5704):2090-2093.
11. Brissot P., Ropert M., Le Lan C., Loréal O. Non-transferrin bound iron: a key role in iron overload and iron toxicity. Biochim Biophys Acta 2012, 1820:403-410.
12. Meynard D., Kautz L., Darnaud V., Canonne-Hergaux F., Coppin H., Roth M.P. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet 2009, 41(4):478-481.
13. Verga Falzacappa M.V., Casanovas G., Hentze M.W., Muckenthaler M.U. A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med 2008, 86(5):531-540.
14. Ramey G., Deschemin J.C., Vaulont S. Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. Haematologica 2009, 94(6):765-772.
15. Hentze M.W., Muckenthaler M.U., Galy B., Camaschella C. Two to tango: regulation of Mammalian iron metabolism. Cell 2010, 142(1):24-38.
16. Deugnier Y., Brissot P., Loréal O. Iron and the liver: update 2008. J Hepatol 2008, 48(Suppl. 1):S113-S123.
17. Pietrangelo A., Caleffi A., Corradini E. Non-HFE hepatic iron overload. Semin Liver Dis 2011, 31(3):302-318.
18. Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003, 101(7):2461-2463.
19. Detivaud L., Nemeth E., Boudjema K., Turlin B., Troadec M.B., Leroyer P., et al. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood 2005, 106(2):746-748.
20. Lambe T., Simpson R.J., Dawson S., Bouriez-Jones T., Crockford T.L., Lepherd M., et al. Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. Blood 2009, 113(8):1805-1808.
21. Gao J., Zhao N., Knutson M.D., Enns C.A. The hereditary hemochromatosis protein HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. J Biol Chem 2008, 283(31):21462-21468.
22. Crichton R. The importance of iron for biological systems. Inorganic biochemistry of iron metabolism. 2001, 17-48. John Wiley and Sons, Chichester. R. Chrichton (Ed.).
23. Levi S., Rovida E. The role of iron in mitochondrial function. Biochim Biophys Acta 2009, 1790(7):629-636.
24. Shi H., Bencze K.Z., Stemmler T.L., Philpott C.C. A cytosolic iron chaperone that delivers iron to ferritin. Science 2008, 320(5880):1207-1210.
25. Bulteau A.L., O'Neill H.A., Kennedy M.C., Ikeda-Saito M., Isaya G., Szweda L.I. Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity. Science 2004, 305(5681):242-245.
26. Worwood M. The laboratory assessment of iron status - an update. Clin Chim Acta 1997, 259(1-2):3-23.
27. Adams P.C., Reboussin D.M., Press R.D., Barton J.C., Acton R.T., Moses G.C., et al. Biological variability of transferrin saturation and unsaturated iron-binding capacity. Am J Med 2007, 120(11):999e1-999e7.
28. Wang W., Knovich M.A., Coffman L.G., Torti F.M., Torti S.V. Serum ferritin: Past, present and future. Biochim Biophys Acta 2010, 1800(8):760-769.
29. Deugnier Y., Moirand R., Guyader D., Brissot P. Diagnosis of hyperferritinemia. Ann Biol Clin (Paris) 1998, 56:41-43. [Spec No].
30. Gandon Y., Olivie D., Guyader D., Aube C., Oberti F., Sebille V., et al. Non-invasive assessment of hepatic iron stores by MRI. Lancet 2004, 363(9406):357-362.
31. Pietrangelo A., Corradini E., Ferrara F., Vegetti A., De Jong G., Luca Abbati G., et al. Magnetic resonance imaging to identify classic and nonclassic forms of ferroportin disease. Blood Cells Mol Dis 2006, 37(3):192-196.
32. Deugnier Y., Turlin B. Pathology of hepatic iron overload. World J Gastroenterol 2007, 13(35):4755-4760.
33. Olsson K.S. Iron stores in normal men and male blood donors. As measured by desferrioxamine and quantitative phlebotomy. Acta Med Scand 1972, 192(5):401-407.
34. Desideri-Vaillant C., Galinat H., Sapin-Lory J., Valero E., Perennec V., Lefevre F. Serum transferrin receptor in the assessment of iron status. Transfus Clin Biol 2011, 18(1):36-39.
35. Kroot J.J., Tjalsma H., Fleming R.E., Swinkels D.W. Hepcidin in human iron disorders: diagnostic implications. Clin Chem 2010, 57(12):1650-1669.
36. Finberg K.E., Heeney M.M., Campagna D.R., Aydinok Y., Pearson H.A., Hartman K.R., et al. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 2008, 40(5):569-571.
37. Yoshida K., Furihata K., Takeda S., Nakamura A., Yamamoto K., Morita H., et al. A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. Nat Genet 1995, 9(3):267-272.
38. Videt-Gibou D., Belliard S., Bardou-Jacquet E., Troadec M.B., Le Lan C., Jouanolle A.M., et al. Iron excess treatable by copper supplementation in acquired aceruloplasminemia: a new form of secondary human iron overload?. Blood 2009, 114(11):2360-2361.