The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively

Journal of Cell Science

Volumn 125, Issue 4, 2012, Pages 887-895

  Klotz, Daniel M ^a   Nelson, Scott A ^a   Kroboth, Karin ^a   Newton, Ian P ^a   Radulescu, Sorina ^b   Ridgway, Rachel A ^b   Sansom, Owen J ^b   Appleton, Paul L ^a   Näthke, Inke S ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Adenomatous polyposis coli; Apoptosis; BIM; Microtubules; Vinorelbine

Indexed keywords

APC PROTEIN; BIM PROTEIN; NAVELBINE; PROTEIN P53;

ARTICLE; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERPHASE; INTESTINE CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN DEPLETION; TARGET CELL; WILD TYPE;

ADENOMA; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; HUMANS; INTERPHASE; MEMBRANE PROTEINS; MICROTUBULES; MITOCHONDRIA; MITOSIS; PROTO-ONCOGENE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; VINBLASTINE;

EID: 84861204950     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.091843     Document Type: Article

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