Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: Regulation of Bcl-2 and implications for cell survival

Journal of Biological Chemistry

Volumn 283, Issue 9, 2008, Pages 5950-5959

  Brocardo, Mariana ^a   Lei, Ying ^a   Tighe, Anthony ^b   Taylor, Stephen S ^b   Mok, Myth T S ^a   Henderson, Beric R ^a  

^a WESTMEAD HOSPITAL   (Australia)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CELL DEATH; CELL MEMBRANES; CONFOCAL MICROSCOPY; LAWS AND LEGISLATION; MITOCHONDRIA; PEPTIDES; PROTEINS; TUMORS;

ADENOMATOUS POLYPOSIS COLI; APOPTOSIS; C TERMINUSES; CATENIN; CELL SURVIVALS; CHROMOSOME SEGREGATIONS; COLON CANCERS; GENE MUTATIONS; MICROTUBULE DYNAMICS; MITOCHONDRIAL FRACTIONS; MITOCHONDRIAL MEMBRANES; MUTANT PEPTIDES; PROTEIN LEVELS; REGULATORY FACTORS; SUBCELLULAR LOCALIZATIONS; SURVIVIN; TRUNCATION MUTANTS; TUMOR CELL SURVIVALS; TUMOR CELLS; TUMOR SUPPRESSORS;

CHEMICAL PLANTS;

APC PROTEIN; BETA CATENIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; SURVIVIN; BAX PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; BIRC5 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN BCL X; TUMOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CHROMOSOME SEGREGATION; COLON CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; MITOCHONDRION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; WILD TYPE; AMINO ACID SEQUENCE; COLON TUMOR; GENE DELETION; GENETICS; METABOLISM; MICROTUBULE; TUMOR CELL LINE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; AMINO ACID SEQUENCE; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BETA CATENIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME SEGREGATION; COLONIC NEOPLASMS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOCHONDRIA; NEOPLASM PROTEINS; SEQUENCE DELETION;

EID: 41949141526     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708775200     Document Type: Article

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