Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol

Oncogene

Volumn 29, Issue 49, 2010, Pages 6418-6427

  Radulescu, S ^a   Ridgway, R A ^a   Appleton, P ^b   Kroboth, K ^b   Patel, S ^c   Woodgett, J ^c   Taylor, S ^d   Nathke, I S ^b   Sansom, O J ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

APC; mitotic spindle assembly checkpoint; Taxol; WNT signalling

Indexed keywords

APC PROTEIN; NAVELBINE; PACLITAXEL; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APC GENE; ARTICLE; CANCER INVASION; CANCER RESISTANCE; CHROMOSOMAL INSTABILITY; COLORECTAL CANCER; CONTROLLED STUDY; DRUG DOSE COMPARISON; GENE MUTATION; IN VIVO STUDY; INTESTINE CELL; MICROTUBULE; MITOSIS SPINDLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; WILD TYPE;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL INSTABILITY; DRUG RESISTANCE, NEOPLASM; ENTEROCYTES; MALE; MICE; MICE, INBRED C57BL; MITOTIC SPINDLE APPARATUS; PACLITAXEL; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE DELETION; VINBLASTINE; WNT PROTEINS;

EID: 78650036168     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.373     Document Type: Article

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