Role of CEACAM1 isoforms in an in vivo model of mammary morphogenesis: Mutational analysis of the cytoplasmic domain of CEACAM1-4S reveals key residues involved in lumen formation

Oncogene

Volumn 26, Issue 55, 2007, Pages 7637-7646

  Yokoyama, S ^a   Chen, C J ^a   Nguyen, T ^a   Shively, J E ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Breast cancer; CEACAM1 4S; Lumen formation; Myofibroblast; Phosphorylation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ASPARTIC ACID; BETA1 INTEGRIN; BETA2 INTEGRIN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; ISOPROTEIN; SERINE; THREONINE; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MAMMARY GLAND; MORPHOGENESIS; MOUSE; MUTATIONAL ANALYSIS; MYOFIBROBLAST; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCID MOUSE;

ANIMALS; ANTIGENS, CD; APOPTOSIS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CYTOPLASM; DNA MUTATIONAL ANALYSIS; FEMALE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INTEGRINS; MAMMARY GLANDS, HUMAN; MICE; MICE, INBRED STRAINS; MODELS, ANIMAL; MORPHOGENESIS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

MUS;

EID: 36849003589     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210577     Document Type: Article

References (35)

1. Barnett TR, Drake L, Pickle II W. (1993). Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins. Mol Cell Biol 13: 1273-1282.
2. Brummer J, Neumaier M, Gopfert C, Wagener C. (1995). Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas. Oncogene 11: 1649-1655.
3. Busch C, Hanssen TA, Wagener C, Obrink B. (2002). Downregulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity increased proliferation rate, Gleason grade 3 to 4 transition. Hum Pathol 33: 290-298.
4. Chen CJ, Kirshner J, Sherman MA, Hu W, Nguyen T, Shively JE. (2007). Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation. J Biol Chem 282: 5749-5760.
5. Edlund M, Wikstrom K, Toomik R, Ek P, Obrink B. (1998). Characterization of protein kinase C-mediated phosphorylation of the short cytoplasmic domain isoform of C-CAM. FEBS Lett 425: 166-170.
6. Greenberg RS, Bernstein AM, Benezra M, Gelman IH, Taliana L, Masur SK. (2006). FAK-dependent regulation of myofibroblast differentiation. Faseb J 20: 1006-1008.
7. Huang J, Hardy JD, Sun Y, Shively JE. (1999). Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. J Cell Sci 112: 4193-4205.
8. Huang J, Simpson JF, Glackin C, Riethorf L, Wagener C, Shively JE. (1998). Expression of biliary glycoprotein (CD66a) in normal and malignant breast epithelial cells. Anticancer Res 18: 3203-3212.
9. Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A et al. (1999). The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. J Biol Chem 274: 335-344.
10. Kirshner J, Chen CJ, Liu P, Huang J, Shively JE. (2003a). CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture. Proc Natl Acad Sci USA 100: 521-526.
11. Kirshner J, Schumann D, Shively JE. (2003b). CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis. J Biol Chem 278: 50338-50345.
12. Kleinerman DI, Dinney CP, Zhang WW, Lin SH, Van NT, Hsieh JT. (1996a). Suppression of human bladder cancer growth by increased expression of C-CAM1 gene in an orthotopic model. Cancer Res 56: 3431-3435.
13. Kleinerman DI, Zhang WW, Lin SH, Nguyen TV, von Eschenbach AC, Hsieh JT. (1995b). Application of a tumor suppressor (C-CAM1)-expressing recombinant adenovirus in androgen-independent human prostate cancer therapy: a preclinical study. Cancer Res 55: 2831-2836.
14. Kunath T, Ordonez-Garcia C, Turbide C, Beauchemin N. (1995). Inhibition of colonic tumor cell growth by biliary glycoprotein. Oncogene 11: 2375-2382.
15. Kuperwasser C, Chavarria T, Wu M, Magrane G, Gray JW, Carey L et al. (2004). Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci USA 101: 4966-4971.
16. Laurie NA, Comegys MM, Carreiro MP, Brown JF, Flanagan DL, Brilliant KE et al. (2005). Carcinoembryonic antigen-related cell adhesion molecule 1a-4L suppression of rat hepatocellular carcinomas. Cancer Res 65: 11010-11017.
17. Leers MP, Kolgen W, Bjorklund V, Bergman T, Tribbick G, Persson B et al. (1999). Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J Pathol 187: 567-572.
18. Luo W, Tapolsky M, Earley K, Wood CG, Wilson DR, Logothetis CJ et al. (1999). Tumor-suppressive activity of CD66a in prostate cancer. Cancer Gene Ther 6: 313-321.
19. Luo W, Wood CG, Earley K, Hung MC, Lin SH. (1997). Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains. Oncogene 14: 1697-1704.
20. Mitra SK, Schlaepfer DD. (2006). Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18: 516-523.
21. Neumaier M, Paululat S, Chan A, Matthaes P, Wagener C. (1993). Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc Natl Acad Sci USA 90: 10744-10748.
22. Nittka S, Gunther J, Ebisch C, Erbersdobler A, Neumaier M. (2004). The human tumor suppressor CEACAM1 modulates apoptosis and is implicated in early colorectal tumorigenesis. Oncogene 23: 9306-9313.
23. Nollau P, Scheller H, Kona-Horstmann M, Rohde S, Hagenmuller F, Wagener C et al. (1997). Dysregulation of carcinoembryonic antigen group members CGM2, CD66a (biliary glycoprotein), and nonspecific cross-reacting antigen in colorectal carcinomas. Comparative analysis by northern blot and in situ hybridization. Cancer Res 57: 2354-2357.
24. Obrink B. (1997). CEA adhesion molecules: multifunctional proteins with signal-regulatory properties. Curr Opin Cell Biol 9: 616-626.
25. Ohwada A, Takahashi H, Nagaoka I, Kira S. (1994). Biliary glycoprotein mRNA expression is increased in primary lung cancer, especially in squamous cell carcinoma. Am J Respir Cell Mol Biol 11: 214-220.
26. Park CC, Zhang H, Pallavicini M, Gray JW, Baehner F, Park CJ et al. (2006). Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res 66: 1526-1535.
27. Peters T, Sindrilaru A, Hinz B, Hinrichs R, Menke A, Al-Azzeh EA et al. (2005). Wound-healing defect of CD18 (-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation. Embo J 24: 3400-3410.
28. Powell DW, Adegboyega PA, Di Mari JF, Mifflin RC. (2005). Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer. Am J Physiol Gastrointest Liver Physiol 289: G2-G7.
29. Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB. (1999). Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am J Physiol 277: C1-C9.
30. Schumann D, Chen CJ, Kaplan B, Shively JE. (2001). Carcinoembryonic antigen cell adhesion molecule 1 directly associates with cytoskeleton proteins actin and tropomyosin. J Biol Chem 276: 47421-47433.
31. Shi S-R, Cote RJ, Taylor CR. (2001). Antigen retrieval techniques: current perspectives. J Histochem Cytochem 49: 931-937.
32. Svenberg T, Hammarstrom S, Zeromski J. (1979). Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues. Clin Exp Immunol 36: 436-441.
33. Tanaka K, Hinoda Y, Takahashi H, Sakamoto H, Nakajima Y, Imai K. (1997). Decreased expression of biliary glycoprotein in hepatocellular carcinomas. Int J Cancer 74: 15-19.
34. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. (2002). Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3: 349-363.
35. Wagener C, Clark BR, Rickard KJ, Shively JE. (1983). Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: a systematic approach for the determination of epitope specificities of monoclonal antibodies. J Immunol 130: 2302-2307.