The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3791-3794

  Sivaramakrishnan, Santhosh ^a   Breydo, Leonid ^a   Sun, Daekyu ^c   Gates, Kent S ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

DNA cleavage; DNA damage

Indexed keywords

1,2 DITHIOLAN 3 ONE 1 OXIDE; DNA; LEINAMYCIN; MACROCYCLIC COMPOUND; OXIDE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DRUG HALF LIFE; DRUG HYDROLYSIS;

BIOLOGICAL AGENTS; DNA; DNA CLEAVAGE; DNA DAMAGE; HYDROLYSIS; LACTAMS; MACROLIDES; OXIDES; SULFHYDRYL COMPOUNDS; THIAZOLES; THIONES;

EID: 84861188120     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.003     Document Type: Article

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