Cyclic Disulfide C(8) Iminoporfiromycin: Nucleophilic Activation of a Porfiromycin

Journal of the American Chemical Society

Volumn 126, Issue 13, 2004, Pages 4281-4292

  Lee, Sang Hyup ^a   Kohn, Harold ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKING; DNA; SOLUTIONS; TOXICITY;

DRUG REACTIVITY; PHARMACOLOGICAL PROFILES;

DRUG PRODUCTS;

7 N (1' AMINO 4',5' DITHIAN 2' YL)PORFIROMYCIN C; 7 N (1' AMINOCYCLOHEX 2' YL)PORFIROMYCIN C; 7 N [2 (4 NITROPHENYLDITHIO)ETHYL]MITOMYCIN C; 7 N [2 [[2 (GAMMA GLUTAMYLAMINO)ETHYL]DITHIO]ETHYL]MITOMYCIN C; DISULFIDE; IMINOPORFIROMYCIN; METHANOL; MITOMYCIN C; PHOSPHINE DERIVATIVE; PORFIROMYCIN; UNCLASSIFIED DRUG; 7 N (1' AMINO 4',5' DITHIAN 2' YL)PORFIROMYCIN CYCLIZED IMINE; 7-N-(1'-AMINO-4',5'-DITHIAN-2'-YL)PORFIROMYCIN CYCLIZED IMINE; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; IMINE; PORFIROMYCIN DNA ADDUCT; PORFIROMYCIN-DNA ADDUCT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DNA ADDUCT; DNA DRUG COMPLEX; DRUG ACTIVATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; SOLVOLYSIS; ANIMAL; CELL HYPOXIA; CHEMISTRY; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL HYPOXIA; CELL LINE, TUMOR; DNA ADDUCTS; IMINES; PORFIROMYCIN;

EID: 1842555122     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja030577r     Document Type: Article

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