1,2-Dithiolan-3-one 1-oxides: A class of thiol-activated DNA-cleaving agents that are structurally related to the natural product leinamycin

Biochemistry

Volumn 35, Issue 6, 1996, Pages 1768-1774

  Behroozi, Saeid J ^a   Kim, Woongki ^a   Dannaldson, Jeffrey ^a   Gates, Kent S ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLAN 3 ONE 1 OXIDE; 3H 1,2 BENZODITHIOL 3 ONE 1 OXIDE; 4 HYDROXYL 4,5,5 TRIMETHYL 1,2 DITHIOLAN 3 ONE 1 OXIDE; 5,5 DIMETHYL 1,2 DITHIOLAN 3 ONE 1 OXIDE; ALCOHOL; ANTINEOPLASTIC ANTIBIOTIC; CATALASE; DITHIOTHREITOL; GLUTATHIONE; LEINAMYCIN; MANNITOL; MERCAPTOETHANOL; METHANOL; PENTETIC ACID; PLASMID DNA; SCAVENGER; SUPEROXIDE DISMUTASE; THIOPHENOL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DNA CLEAVAGE; DRUG SYNTHESIS; ESCHERICHIA COLI; GEL ELECTROPHORESIS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

ANTIBIOTICS, ANTINEOPLASTIC; DNA; LACTAMS; MACROLIDES; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; THIAZOLES; THIONES; THIOPHENES;

EID: 0029670818     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi952257t     Document Type: Article

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