Oxidative DNA cleavage by the antitumor antibiotic leinamycin and simple 1,2-dithiolan-3-one 1-oxides: Evidence for thiol-dependent conversion of molecular oxygen to DNA-cleaving oxygen radicals mediated by polysulfides

Journal of the American Chemical Society

Volumn 119, Issue 48, 1997, Pages 11691-11692

  Mitra, K ^a   Kim, W ^a   Daniels, J S ^a   Gates, K S ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLANE 1 OXIDE DERIVATIVE; ANTINEOPLASTIC ANTIBIOTIC; LEINAMYCIN; ORGANOSULFUR DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DNA CLEAVAGE; IN VITRO STUDY; REACTION ANALYSIS;

EID: 0031439957     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja971359z     Document Type: Article

References (29)