Potential allergenicity research of Cry1C protein from genetically modified rice

Regulatory Toxicology and Pharmacology

Volumn 63, Issue 2, 2012, Pages 181-187

  Cao, Sishuo ^a   He, Xiaoyun ^a,c   Xu, Wentao ^a,b   Luo, YunBo ^a   Ran, Wenjun ^a   Liang, Lixing ^a   Dai, Yunqing ^a   Huang, Kunlun ^a,b  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^c Beijing Asia Pacific Resources and Feed Technology Co Ltd   (China)

Author keywords

BN rats; Cry1C protein; Genetically modified crops; Potential allergenicity

Indexed keywords

ACID PHOSPHATASE; ALLERGEN; CRY1C PROTEIN; CYTOKINE; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; MESSENGER RNA; OVALBUMIN; PEANUT AGGLUTININ; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ALLERGENICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CONTACT SENSITIZATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL COUNT; FEMALE; GENE; GENE EXPRESSION REGULATION; HISTAMINE BLOOD LEVEL; IFN GAMMA GENE; IL 10 GENE; IL 13 GENE; IL 4 GENE; IL 5 GENE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREACTIVITY; LONG TERM EXPOSURE; MAST CELL; NONHUMAN; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROVOCATION TEST; RAT; RESEARCH PRIORITY; TH1 CELL; TH2 CELL; TRANSGENIC PLANT;

ACID PHOSPHATASE; ANIMALS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILS; ESCHERICHIA COLI; FEMALE; FOOD HYPERSENSITIVITY; FOOD, GENETICALLY MODIFIED; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MAST CELLS; ORYZA SATIVA; OVALBUMIN; PEANUT AGGLUTININ; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; RATS; RATS, INBRED BN; REAL-TIME POLYMERASE CHAIN REACTION;

ARACHIS HYPOGAEA; RATTUS; RATTUS NORVEGICUS; SOLANUM TUBEROSUM;

EID: 84861165979     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.03.017     Document Type: Article

References (39)

1. Alcantara E.P., Aguda R.M., Curtiss A., Dean D.H., Cohen M.B. Bacillus thuringiensis d-endotoxin binding to brush border membrane vesicles of rice stem borers. Arch. Ins. B. 2004, 55:169-177.
2. Atkinson H.A., Johnson I.T., Gee J.M., Grigoriadou F., Miller K. Brown Norway rat model of food allergy: effect of plant components on the development of oral sensitization. Food Chem. Toxicol. 1996, 34:27-32.
3. Cao S.S., He X.Y., Xu W.T., Ran W.J., Liang L.X., Luo Y.B., Yuan Y.F., Zhang N., Zhou X., Huang K.L. Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource. Regul. Toxocol. Pharm. 2010, 58:474-481.
4. Cao S.S., Xu W.T., Ran W.J., Liang L.X., He X.Y., Luo Y.B., Yuan Y.F., Huang K.L. Expression, purification and refolding of recombinant Cry1C gene obtained in E.coli as inclusion bodies. Food Sci. 2011, 32:211-215.
5. Cao S.S., He X.Y., Xu W.T., Luo Y.B., Yuan Y.F., Liu P.F., Cao B., Shi H., Huang K.L. Safety assessment of transgenic Bacillus thuringiensis rice T1c-19 in Sprague-Dawley rats from metabonomics and bacterial profile perspectives. IUBMB Life 2012, 64(3):242-250.
6. Dearman R.J., Kimber I. Determination of protein allergenicity: studies in mice. Toxicol. Lett. 2001, 120:181-186.
7. Dioun A.F., Harris S.K., Hibberd P.L. Is maternal age at delivery related to childhood food allergy?. Pediatr. A 2003, 14:307-311.
8. Dvorak A.M., Onderdonk A.B., McLeod R.S., Monahan-Earley R.A., Antonioli D.A., Cullen J., Blair J.E., Cisneros R., Letourneau L., Morgan E., et al. Ultrastructural identification of exocytosis of granules from human gut eosinophils in vivo. Int. Arch. Allergy Immunol. 1993, 102(1):33-45.
9. Ferré J., Van Rie J. Biochemistry and genetics of insect resistance to Bacillus thuringiensis. Ann. Rev. Entomol. 2002, 47:501-533.
10. Ferreira M.A. Cytokine expression in allergic inflammation: systematic review of in vivo challenge studies. Mediat. Inflamm. 2003, 12(5):259-267.
11. Food and Agriculture Organization/World Health Organization. 2001. Report of a Joint FAO/WHO Expert Consultation on Allergenicity of Foods Derived from Biotechnology.
12. Fu T.J., Abbott U., Hatzos C. Digestibility of food allergens and non-allergenic proteins in simulated gastric and intestinal fluids - a comparative study. J. Agr. Food Chem. 2002, 50:7154-7160.
13. Gould F., Anderson A., Reynolds A., Bumgarner L., Moar W. Selection and genetic analysis of a Heliothis virescens (Lepidoptera: Noctuidae) strain with high levels of resistance to Bacillus thuringiensis toxins. J. Econ. Entomol. 1995, 88:1545-1559.
14. Hama H., Suzuki K., Tanaka H. Inheritance and stability of resistance to Bacillus thuringiensis formulations of the diamondback moth, Plutella xylostella (Linnaeus) (Lepidoptera: Yponomeutidae). Appl. Entomol. Zool. 1992, 27:355-362.
15. Helm R.M. Food biotechnology: is this good or bad? Implications to allergic diseases. Ann. Allergy A 2003, 90:90-98.
16. Hogan S.P., Mishra A., Brandt E.B., Foster P.S., Rothenberg M.E. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy. Proc. Natl. Acad. Sci. USA. 2000, 97(12):6681-6686.
17. Hollingworth, R.M., Bjeldanes, L.F., Bolger, M., Kimber, I., Meade, B.J., Taylor, S.L., Wallace, K.B., Society of Toxicology ad hoc Working Group., 2003. The Safety of Genetically Modified Foods Produced through Biotechnology. Toxicol. Sci. 71, 2-8.
18. Kain W.C., Zhao J.Z., Janmaat A.F., Myers J., Shelton A.M., Wang P. Inheritance of resistance to Bacillus thuringiensis Cry1Ac toxin in a greenhouse-derived strain of cabbage looper (Lepidoptera: Noctuidae). J. Econ. Entomol. 2004, 97:2073-2078.
19. Kato M., Kephart G.M., Talley N.J., Wagner J.M., Sarr M.G., Bonno M., McGovern T.W., Gleich G.J. Eosinophil infiltration and degranulation in normal human tissue. Anat. Rec. 1998, 252(3):418-425.
20. Knippels L.M., Penninks A.H. Assessment of the allergic potential of food protein extracts and proteins on oral application using the Brown Norway rat model. Environ. Health Persp. 2003, 111:233-238.
21. Knippels L.M., Penninks A.H. Recent advances using rodent models for predicting human allergenicity. Toxicol. Appl. Pharm. 2005, 207:157-160.
22. Knippels L.M., Penninks A.H., Houben G.F. Continued expression of anti-soy protein antibodies in rats bred on a soy protein-free diet for one generation: the importance of dietary control in oral sensitization research. J. Allergy Clin Immunol. 1998, 101:815-820.
23. Knippels L.M., Penninks A.H., Spanhaak S., Houben G.F. Oral sensitization to food proteins: a Brown Norway rat model. Clin. Exp. Allergy 1998, 28:368-375.
24. Knippels L.M., Penninks A.H., Smit J.J., Houben G.F. Immune-mediated effects upon oral challenge of ovalbumin-sensitized Brown Norway rats: further characterization of a rat food allergy model. Toxicol. Appl. Pharm. 1999, 156:161-169.
25. Knippels L.M., Penninks A.H., van Meeteren M., Houben G.F. Humoral and cellular immune responses in different rat strains on oral exposure to ovalbumin. Food Chem. Toxicol. 1999, 37:881-888.
26. Knippels L.M., van der Kleij H.P., Koppelman S.J., Houben G.F., Penninks A.H. Comparison of antibody responses to hen's egg and cow's milk proteins in orally sensitized rats and food-allergic patients. Allergy 2000, 55:251-258.
27. Lack G., Chapman M., Kalsheker N., King V., Robinson C., Venables K. Report on the potential allergenicity of genetically modified organisms and their products. Clin. Exp. Allergy 2002, 32:1131-1143.
28. Ladics G.S., Knippels L.M., Penninks A.H., Bannon G.A., Goodman R.E., Herouet-Guicheney C. Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops. Regul. Toxicol. Pharm. 2010, 56:212-224.
29. Maciorkowska E., Panasiuk A., Kaczmarsk M. Concentrations of gastric mucosal cytokines in children with food allergy and Helicobacter pylori infection. World J. Gastroenterol. 2005, 11(43). 6751-6746.
30. McGaughey W.H. Insect resistance to the biological insecticide Bacillus thuringiensis. Science 1985, 229:193-195.
31. National Institute of Allergy and Infectious Diseases, 2006. National Institutes of Health. Report of the NIH Expert Panel on Food Allergy Research.
32. Penninks A.H., Knippels L.M. Determination of protein allergenicity: studies in rats. Toxicol. Lett. 2001, 2001(120):171-180.
33. Pilegaard K., Madsen C. An oral Brown Norway rat model for food allergy: comparison of age, sex, dosing volume, and allergen preparation. Toxicology 2004, 196:247-257.
34. Sampson H.A. Food allergy. Part 1: immunopathogenesis and clinical disorders. J. Allergy Clin. Immunol. 1999, 103:717-728.
35. Sayyed A.H., Haward R., Herrero S., Ferré J., Wright D.J. Genetic and biochemical approach for characterization of resistance to Bacillus thuringiensis toxin Cry1Ac in a field population of the diamondback moth, Plutella xylostella. Appl. Environ. 2000, 66:1509-1516.
36. Selgrade M.K., Kimber I., Goldman L., Germolec D.R. Assessment of allergenic potential of genetically modified foods: an agenda for future research. Envir. Health Persp. 2003, 111:1140-1141.
37. Sicherer S.H., Munoz-Furlong A., Sampson H.A. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: A 5-year follow-up study. J. Allergy Clin. Immunol. 2003, 112:1203-1207.
38. Taylor S.L., Hefle S.L. Will genetically modified foods be allergenic?. J. Allergy Clin. Immunol. 2001, 107:765-771.
39. Xu W.T., Cao S.S., He X.Y., Luo Y.B., Guo X., Yuan Y.F., Huang K.L. Safety Assessment of Cry1Ab/Ac fusion protein. Food Chem. Toxicol. 2009, 47:1459-1465.