Novel 1,2,4-Triazolo[1,5- a ]pyridines and their fused ring systems attenuate oxidative stress and prolong lifespan of caenorhabiditis elegans

Journal of Medicinal Chemistry

Volumn 55, Issue 9, 2012, Pages 4169-4177

  Mekheimer, Ramadan Ahmed ^a,b   Sayed, Ahmed Amir Radwan ^a,b   Ahmed, Eltaib Ali ^c  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b El Minia University ^*  (Egypt)

^c Faculty of Education   (Sudan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIAZOLO[1,5 A]PYRIDINE; 7 ALKYLAMINO 2 ETHYLTHIO 5 OXO 1 PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 6,8 DICARBONITRILE; 7 ALKYLAMINO 2 ETHYLTHIO 6 [(HYDROXYIMINO)METHYL] 5 OXO 1 PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; 7 AMINO 2 ETHYLTHIO 1,5 DIHYDRO 5 OXO 1 PHENYL 1,2,4 TRIAZOLO [1,5 A]PYRIDINE 6,8 DICARBONITRILE; 7 AMINO 2 ETHYLTHIO 6 [(HYDROXYIMINO)METHYL] 5 OXO 1 PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; 7 AZIDO 2 ETHYLTHIO 1,5 DIHYDRO 5 OXO 1 PHENYL 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 6,8 DICARBONITRILE; 7 AZIDO 2 ETHYLTHIO 6 [(HYDROXYIMINO)METHYL] 5 OXO 1 PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; 7 AZIDO 6 ETHOXYCARBONYLVINYL 2ETHYLTHIO 1,5 DIHYDRO 5 OXO 1 PHENYL 1,2,4 TRIAZOL[1,5 A]PYRIDINE 8 CARBONITRILE; 7 BUTYLAMINO 2 ETHYLTHIO 5 OXO 1 PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 6,8 DICARBONITRILE; 7 BUTYLAMINO 2 ETHYLTHIO-6 [(HYDROXYIMINO)METHYL] 5 OXO 1 PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; 7 CHLORO 2 ETHYLTHIO 1,5 DIHYDRO 5 OXO 1 PHENYL 1,2,4 TRIAZOLO [1,5 A]PYRIDINE 6,8 DICARBONITRILE; 7 CHLORO 2 ETHYLTHIO 6 [(HYDROXYIMINO)METHYL] 5 OXO 1PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; 7 E THYLTHIO 2 HYDROXY 4 OXO 8 PHENYL 4,8 DIHYDRO 2H PYRAZOLO [3,4 D] 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 9 CARBONITRILE; 7 ETHYLTHIO 4 OXO 8 PHENYL 4,8 DIHYDRO ISOXAZOLO[3,4 D]1,2,4 TRIAZOLO[1,5 A]PYRIDINE 9 CARBONITRILE; 7 ISOBUTYLAMINO 2 ETHYLTHIO 5 OXO 1 PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 6,8 DICARBONITRILE; 7 ISOBUTYLAMINO 2 ETHYLTHIO 6 [(HYDROXYIMINO)METHYL] 5 OXO 1 PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; ADVANCED GLYCATION END PRODUCT; ETHYL 9 CYANO 2 ETHYLTHIO 5OXO 1 PHENYL 5,8 DIHYDRO 1H PYRROLO[2,3 D] 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 7 CARBOXYLIC ACID; FUSED HETEROCYCLIC RINGS; MALONALDEHYDE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CAENORHABDITIS ELEGANS; CHEMICAL STRESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG SYNTHESIS; HEAT STRESS; LIFESPAN; NONHUMAN; OXIDATIVE STRESS; WORM;

AGE FACTORS; ANIMALS; ANTIOXIDANTS; CAENORHABDITIS ELEGANS; GLYCOSYLATION END PRODUCTS, ADVANCED; KAPLAN-MEIER ESTIMATE; MAGNETIC RESONANCE SPECTROSCOPY; MALONDIALDEHYDE; MASS SPECTROMETRY; OXIDATIVE STRESS; PYRIDINES; SPECTROPHOTOMETRY, INFRARED; TRIAZOLES;

EID: 84861089114     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2014315     Document Type: Article

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