Synthesis of fluorine substituted pyrazolopyrimidines as potential leads for the development of PET-imaging agents for the GABAA receptors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 3, 2008, Pages 1184-1194

  Hoepping, Alexander ^a   Diekers, Michael ^a   Deuther Conrad, Winnie ^b   Scheunemann, Matthias ^b   Fischer, Steffen ^b   Hiller, Achim ^b   Wegner, Florian ^c   Steinbach, Jörg ^b   Brust, Peter ^b  

^a ABX Advanced Biochemical Compounds GmbH   (Germany)

^b Institute of Interdisciplinary Isotope Research   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Fluorine 18; GABAA; Indiplon; PET

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; FLUORINE; INDIPLON; N (3 FLUOROPROPYL) N [3 [3 (THIOPHENE 2 CARBONYL) PYRAZOLO[1,5 A]PYRIMIDIN 7 YL] PHENYL] ACETAMIDE; PYRAZOLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; FEMALE; FLUORINATION; GABAERGIC TRANSMISSION; IN VITRO STUDY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; SYNTHESIS;

ANIMALS; FEMALE; FLUORINE; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38849119105     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.079     Document Type: Article

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