Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKCι in complex with a substrate peptide from Par-3

Structure

Volumn 20, Issue 5, 2012, Pages 791-801

  Wang, Chihao ^a   Shang, Yuan ^a   Yu, Jiang ^a,b   Zhang, Mingjie ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE C IOTA; PROTEINASE ACTIVATED RECEPTOR 3;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL ADHESION MOLECULES; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ISOENZYMES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 84861073615     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2012.02.022     Document Type: Article

References (43)

1. J.A. Adams Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model? Biochemistry 42 2003 601 607 (Pubitemid 36133283)
2. P.D. Adams, P.V. Afonine, G. Bunkóczi, V.B. Chen, I.W. Davis, N. Echols, J.J. Headd, L.W. Hung, G.J. Kapral, and R.W. Grosse-Kunstleve PHENIX: a comprehensive Python-based system for macromolecular structure solution Acta Crystallogr. D Biol. Crystallogr. 66 2010 213 221
3. A. Behn-Krappa, and A.C. Newton The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation Curr. Biol. 9 1999 728 737 (Pubitemid 29350851)
4. J. Betschinger, K. Mechtler, and J.A. Knoblich The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl Nature 422 2003 326 330 (Pubitemid 36378361)
5. P. Emsley, and K. Cowtan Coot: model-building tools for molecular graphics Acta Crystallogr. D Biol. Crystallogr. 60 2004 2126 2132 (Pubitemid 41742764)
6. S. Etienne-Manneville, and A. Hall Cell polarity: Par6, aPKC and cytoskeletal crosstalk Curr. Opin. Cell Biol. 15 2003 67 72 (Pubitemid 36044717)
7. A.P. Fields, and R.P. Regala Protein kinase C iota: human oncogene, prognostic marker and therapeutic target Pharmacol. Res. 55 2007 487 497 (Pubitemid 46962307)
8. N. Goode, K. Hughes, J.R. Woodgett, and P.J. Parker Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes J. Biol. Chem. 267 1992 16878 16882
9. N. Grodsky, Y. Li, D. Bouzida, R. Love, J. Jensen, B. Nodes, J. Nonomiya, and S. Grant Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor Biochemistry 45 2006 13970 13981 (Pubitemid 44846186)
10. Y. Hao, Q. Du, X. Chen, Z. Zheng, J.L. Balsbaugh, S. Maitra, J. Shabanowitz, D.F. Hunt, and I.G. Macara Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins Curr. Biol. 20 2010 1809 1818
11. D. Henrique, and F. Schweisguth Cell polarity: the ups and downs of the Par6/aPKC complex Curr. Opin. Genet. Dev. 13 2003 341 350 (Pubitemid 36897796)
12. T. Herget, S.A. Oehrlein, D.J.C. Pappin, E. Rozengurt, and P.J. Parker The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C Eur. J. Biochem. 233 1995 448 457
13. C. House, and B.E. Kemp Protein kinase C contains a pseudosubstrate prototype in its regulatory domain Science 238 1987 1726 1728 (Pubitemid 18046276)
14. D.A. Johnson, P. Akamine, E. Radzio-Andzelm, M. Madhusudan, and S.S. Taylor Dynamics of cAMP-dependent protein kinase Chem. Rev. 101 2001 2243 2270 (Pubitemid 35373018)
15. M. Kalive, J.J. Faust, B.A. Koeneman, and D.G. Capco Involvement of the PKC family in regulation of early development Mol. Reprod. Dev. 77 2010 95 104
16. A.P. Kornev, S.S. Taylor, and L.F. Ten Eyck A helix scaffold for the assembly of active protein kinases Proc. Natl. Acad. Sci. USA 105 2008 14377 14382
17. J.A. Le Good, W.H. Ziegler, D.B. Parekh, D.R. Alessi, P. Cohen, and P.J. Parker Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1 Science 281 1998 2042 2045 (Pubitemid 28475494)
18. T.A. Leonard, B. Różycki, L.F. Saidi, G. Hummer, and J.H. Hurley Crystal structure and allosteric activation of protein kinase C βII Cell 144 2011 55 66
19. G. Martiny-Baron, and D. Fabbro Classical PKC isoforms in cancer Pharmacol. Res. 55 2007 477 486 (Pubitemid 46970734)
20. A.J. McCoy, R.W. Grosse-Kunstleve, P.D. Adams, M.D. Winn, L.C. Storoni, and R.J. Read Phaser crystallographic software J. Appl. Cryst. 40 2007 658 674 (Pubitemid 47080256)
21. A. Messerschmidt, S. Macieira, M. Velarde, M. Bädeker, C. Benda, A. Jestel, H. Brandstetter, T. Neuefeind, and M. Blaesse Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif J. Mol. Biol. 352 2005 918 931 (Pubitemid 41267077)
22. E. Morais-de-Sá, V. Mirouse, and D. St. Johnston aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells Cell 141 2010 509 523
23. Y. Nagai-Tamai, K. Mizuno, T. Hirose, A. Suzuki, and S. Ohno Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells Genes Cells 7 2002 1161 1171 (Pubitemid 35256337)
24. A.C. Newton Regulation of protein kinase C Curr. Opin. Cell Biol. 9 1997 161 167 (Pubitemid 27135982)
25. A.C. Newton Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm Biochem. J. 370 2003 361 371 (Pubitemid 36315124)
26. K. Nishikawa, A. Toker, F.J. Johannes, Z. Songyang, and L.C. Cantley Determination of the specific substrate sequence motifs of protein kinase C isozymes J. Biol. Chem. 272 1997 952 960 (Pubitemid 27034586)
27. Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode Methods Enzymol. 276 1997 307 326 (Pubitemid 27085611)
28. L.R. Pearce, D. Komander, and D.R. Alessi The nuts and bolts of AGC protein kinases Nat. Rev. Mol. Cell Biol. 11 2010 9 22
29. C.P. Ponting, and P.J. Parker Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin Protein Sci. 5 1996 162 166
30. K.E. Prehoda Polarization of Drosophila neuroblasts during asymmetric division Cold Spring Harb. Perspect. Biol. 1 2009 a001388
31. S. Ranganathan, Y. Wang, F.G. Kern, Z. Qu, and R. Li Activation loop phosphorylation-independent kinase activity of human protein kinase C zeta Proteins 67 2007 709 719 (Pubitemid 46625586)
32. C.A. Smith, K.M. Lau, Z. Rahmani, S.E. Dho, G. Brothers, Y.M. She, D.M. Berry, E. Bonneil, P. Thibault, and F. Schweisguth aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb EMBO J. 26 2007 468 480 (Pubitemid 46160947)
33. S. Sotillos, M.T. Díaz-Meco, E. Caminero, J. Moscat, and S. Campuzano DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila J. Cell Biol. 166 2004 549 557 (Pubitemid 39097174)
34. L. Stempka, A. Girod, H.J. Müller, G. Rincke, F. Marks, M. Gschwendt, and D. Bossemeyer Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form J. Biol. Chem. 272 1997 6805 6811 (Pubitemid 27118170)
35. A. Suzuki, K. Akimoto, and S. Ohno Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms J. Biochem. 133 2003 9 16 (Pubitemid 36240973)
36. T. Takimura, K. Kamata, K. Fukasawa, H. Ohsawa, H. Komatani, T. Yoshizumi, I. Takahashi, H. Kotani, and Y. Iwasawa Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding Acta Crystallogr. D Biol. Crystallogr. 66 2010 577 583
37. S.L. Tan, and P.J. Parker Emerging and diverse roles of protein kinase C in immune cell signalling Biochem. J. 376 2003 545 552 (Pubitemid 38058054)
38. S.S. Taylor, and A.P. Kornev Protein kinases: evolution of dynamic regulatory proteins Trends Biochem. Sci. 36 2011 65 77
39. J. Wagner, P. von Matt, R. Sedrani, R. Albert, N. Cooke, C. Ehrhardt, M. Geiser, G. Rummel, W. Stark, and A. Strauss Discovery of 3-(1H-indol-3-yl)-4-[2- (4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes J. Med. Chem. 52 2009 6193 6196
40. B.L. Webb, S.J. Hirst, and M.A. Giembycz Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis Br. J. Pharmacol. 130 2000 1433 1452 (Pubitemid 30611917)
41. Z.B. Xu, D. Chaudhary, S. Olland, S. Wolfrom, R. Czerwinski, K. Malakian, L. Lin, M.L. Stahl, D. Joseph-McCarthy, and C. Benander Catalytic domain crystal structure of protein kinase C-theta (PKCtheta) J. Biol. Chem. 279 2004 50401 50409 (Pubitemid 39577858)
42. J. Yang, P. Cron, V.M. Good, V. Thompson, B.A. Hemmings, and D. Barford Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP Nat. Struct. Biol. 9 2002 940 944 (Pubitemid 35417064)
43. J. Zheng, E.A. Trafny, D.R. Knighton, N.H. Xuong, S.S. Taylor, L.F. Ten Eyck, and J.M. Sowadski 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor Acta Crystallogr. D Biol. Crystallogr. 49 1993 362 365