Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical pins

Current Biology

Volumn 20, Issue 20, 2010, Pages 1809-1818

  Hao, Yi ^a   Du, Quansheng ^b   Chen, Xinyu ^c   Zheng, Zhen ^b   Balsbaugh, Jeremy L ^a   Maitra, Sushmit ^a   Shabanowitz, Jeffrey ^a   Hunt, Donald F ^a   MacAra, Ian G ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; GPSM2 PROTEIN, HUMAN; MEMBRANE PROTEIN; PARD3 PROTEIN, HUMAN; PKC 3 PROTEIN; PKC-3 PROTEIN; PROTEIN KINASE C; SIGNAL PEPTIDE;

ANIMAL; ARTICLE; CELL LINE; CELL POLARITY; DOG; EPITHELIUM CELL; FLUORESCENCE MICROSCOPY; GENETICS; HUMAN; IMMUNOPRECIPITATION; LIQUID CHROMATOGRAPHY; METABOLISM; MICROTUBULE; MITOSIS SPINDLE; PHOSPHORYLATION; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; TANDEM MASS SPECTROMETRY;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CELL POLARITY; CHROMATOGRAPHY, LIQUID; DOGS; EPITHELIAL CELLS; HUMANS; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MITOTIC SPINDLE APPARATUS; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN KINASE C; TANDEM MASS SPECTROMETRY;

MAMMALIA;

EID: 78049255724     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2010.09.032     Document Type: Article

References (31)

1. K.H. Siller, and C.Q. Doe Spindle orientation during asymmetric cell division Nat. Cell Biol. 11 2009 365 374
2. J.A. Knoblich Mechanisms of asymmetric stem cell division Cell 132 2008 583 597
3. F. Yu, C.T. Kuo, and Y.N. Jan Drosophila neuroblast asymmetric cell division: Recent advances and implications for stem cell biology Neuron 51 2006 13 20
4. S.E. Siegrist, and C.Q. Doe Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts Cell 123 2005 1323 1335
5. P. Gönczy Mechanisms of asymmetric cell division: Flies and worms pave the way Nat. Rev. Mol. Cell Biol. 9 2008 355 366
6. C.R. Cowan, and A.A. Hyman Asymmetric cell division in C. elegans: Cortical polarity and spindle positioning Annu. Rev. Cell Dev. Biol. 20 2004 427 453
7. W.J. Nelson Adaptation of core mechanisms to generate cell polarity Nature 422 2003 766 774
8. D.M. Bryant, and K.E. Mostov From cells to organs: Building polarized tissue Nat. Rev. Mol. Cell Biol. 9 2008 887 901
9. A.B. Jaffe, N. Kaji, J. Durgan, and A. Hall Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis J. Cell Biol. 183 2008 625 633
10. Y. Qin, W.H. Meisen, Y. Hao, and I.G. Macara Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation J. Cell Biol. 189 2010 661 669
11. A.E. Rodriguez-Fraticelli, S. Vergarajauregui, D.J. Eastburn, A. Datta, M.A. Alonso, K. Mostov, and F. Martín-Belmonte The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis J. Cell Biol. 189 2010 725 738
12. Z. Zheng, H. Zhu, Q. Wan, J. Liu, Z. Xiao, D.P. Siderovski, and Q. Du LGN regulates mitotic spindle orientation during epithelial morphogenesis J. Cell Biol. 189 2010 275 288
13. B. Goldstein, and I.G. Macara The PAR proteins: Fundamental players in animal cell polarization Dev. Cell 13 2007 609 622
14. R. Montesano, G. Schaller, and L. Orci Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors Cell 66 1991 697 711
15. M. Schaefer, M. Petronczki, D. Dorner, M. Forte, and J.A. Knoblich Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system Cell 107 2001 183 194
16. R.W. Nipper, K.H. Siller, N.R. Smith, C.Q. Doe, and K.E. Prehoda Galphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts Proc. Natl. Acad. Sci. USA 104 2007 14306 14311
17. Q. Du, and I.G. Macara Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins Cell 119 2004 503 516
18. Y. Horikoshi, A. Suzuki, T. Yamanaka, K. Sasaki, K. Mizuno, H. Sawada, S. Yonemura, and S. Ohno Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells J. Cell Sci. 122 2009 1595 1606
19. X. Chen, and I.G. Macara Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly J. Cell Biol. 172 2006 671 678
20. X. Chen, and I.G. Macara Par-3 controls tight junction assembly through the Rac exchange factor Tiam1 Nat. Cell Biol. 7 2005 262 269
21. L.M. McCaffrey, and I.G. Macara The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis Genes Dev. 23 2009 1450 1460
22. T. Takeda Podocyte cytoskeleton is connected to the integral membrane protein podocalyxin through Na+/H+-exchanger regulatory factor 2 and ezrin Clin. Exp. Nephrol. 7 2003 260 269
23. Y. Li, J. Li, S.W. Straight, and D.B. Kershaw PDZ domain-mediated interaction of rabbit podocalyxin and Na(+)/H(+) exchange regulatory factor-2 Am. J. Physiol. Renal Physiol. 282 2002 F1129 F1139
24. M. Kusakabe, and E. Nishida The polarity-inducing kinase Par-1 controls Xenopus gastrulation in cooperation with 14-3-3 and aPKC EMBO J. 23 2004 4190 4201
25. A. Suzuki, M. Hirata, K. Kamimura, R. Maniwa, T. Yamanaka, K. Mizuno, M. Kishikawa, H. Hirose, Y. Amano, and N. Izumi aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity Curr. Biol. 14 2004 1425 1435
26. F.S. Willard, R.J. Kimple, and D.P. Siderovski Return of the GDI: The GoLoco motif in cell division Annu. Rev. Biochem. 73 2004 925 951
27. E. Morais-de-Sá, V. Mirouse, and D. St Johnston aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells Cell 141 2010 509 523
28. C.A. Johnston, K. Hirono, K.E. Prehoda, and C.Q. Doe Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells Cell 138 2009 1150 1163
29. J.B. Hurov, J.L. Watkins, and H. Piwnica-Worms Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity Curr. Biol. 14 2004 736 741
30. L.E. O'Brien, T.S. Jou, A.L. Pollack, Q. Zhang, S.H. Hansen, P. Yurchenco, and K. Mostov Rac1 orients epithelial apical polarity through effects on basolateral laminin assembly Nat. Cell Biol. 3 2001 831 838
31. N.D. Udeshi, P.D. Compton, J. Shabanowitz, D.F. Hunt, and K.L. Rose Methods for analyzing peptides and proteins on a chromatographic timescale by electron-transfer dissociation mass spectrometry Nat. Protoc. 3 2008 1709 1717