The prediction of drug metabolism using scaffold-mediated enhancement of the induced cytochrome P450 activities in fibroblasts by hepatic transcriptional regulators

Biomaterials

Volumn 33, Issue 21, 2012, Pages 5187-5197

  Chiang, Tsai Shin ^a   Yang, Kai Chiang ^b   Zheng, Shu Kai ^c   Chiou, Ling Ling ^d   Hsu, Wen Ming ^c   Lin, Feng Huei ^e   Huang, Guan Tarn ^c   Lee, Hsuan Shu ^a,c,f  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d Liver Disease Prevention and Treatment Research Foundation   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

Author keywords

Cytochrome P450; Drug metabolism; Human dermal fibroblast; Scaffold; Transcriptional regulator

Indexed keywords

ANTI-HYPERTENSION DRUGS; CHONDROITIN; CYTOCHROME P450; DRUG METABOLISMS; HEPATOMA CELLS; HUMAN DERMAL FIBROBLASTS; HUMAN RISKS; HYALURONAN; IN-VITRO; NIFEDIPINE; NUCLEAR RECEPTORS; SURVIVAL RATE; SYNERGISTIC EFFECT; TOXICITY PREDICTIONS; TRANSCRIPTIONAL REGULATOR;

BIOMATERIALS; CARBOXYLIC ACIDS; CELL CULTURE; CONFOCAL MICROSCOPY; COPOLYMERS; FORECASTING; METABOLISM; PHYSIOLOGY; PYRIDINE; SCAFFOLDS; SCANNING ELECTRON MICROSCOPY; TOXICITY; TRANSCRIPTION FACTORS;

SCAFFOLDS (BIOLOGY);

CELL NUCLEUS RECEPTOR; CHONDROITIN; COPOLYMER; CYTOCHROME P450 1B1; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; GELATIN; HEPATOCYTE ENRICHED TRANSCRIPTION FACTOR; HYALURONIC ACID; NIFEDIPINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ANALYSIS; FIBROBLAST; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PLASMID; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPRODUCIBILITY; SCANNING ELECTRON MICROSCOPY; SPHEROID CELL; SURVIVAL RATE;

CELL LINE, TUMOR; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DERMIS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; LIVER; METABOLIC DETOXICATION, DRUG; POLYMERASE CHAIN REACTION; POLYMERS; SPHEROIDS, CELLULAR; TISSUE SCAFFOLDS; TRANSCRIPTION FACTORS;

EID: 84860918965     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.04.014     Document Type: Article

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