The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold

PLoS Pathogens

Volumn 8, Issue 2, 2012, Pages

  Zhang, Adrianna P P ^a   Bornholdt, Zachary A ^a   Liu, Tong ^b   Abelson, Dafna M ^a   Lee, David E ^b   Li, Sheng ^b   Woods, Virgil L ^b   Saphire, Erica Ollmann ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STAT1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PARTICLE 24; VIRUS PROTEIN; INTERFERON; KARYOPHERIN ALPHA; VP24 PROTEIN, EBOLA VIRUS;

ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; CRYSTAL STRUCTURE; EBOLA VIRUS; IMMUNE DEFICIENCY; LIFE CYCLE; MASS SPECTROMETRY; NONHUMAN; PATHOGENICITY; PROTEIN BINDING; VIRUS PARTICLE; VIRUS VIRULENCE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN DOMAIN; PROTEIN FOLDING;

EBOLA VIRUS;

ALPHA KARYOPHERINS; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; EBOLAVIRUS; HEK293 CELLS; HUMANS; INTERFERONS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; STAT1 TRANSCRIPTION FACTOR; VIRAL PROTEINS;

EID: 84860903741     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002550     Document Type: Article

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