메뉴 건너뛰기




Volumn 4, Issue 10, 2010, Pages

Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; COLONY STIMULATING FACTOR 1; CXCL1 CHEMOKINE; EOTAXIN; FAS ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GROWTH FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 16; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE MIGRATION INHIBITION FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES; STROMAL CELL DERIVED FACTOR 1; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

EID: 78449261317     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000837     Document Type: Article
Times cited : (313)

References (73)
  • 1
    • 33646584499 scopus 로고    scopus 로고
    • Ebola virus: Unravelling pathogenesis to combat a deadly disease
    • Hoenen T, Groseth A, Falzarano D, Feldmann H (2006) Ebola virus: unravelling pathogenesis to combat a deadly disease. Trends Mol Med 12: 206-215.
    • (2006) Trends Mol Med , vol.12 , pp. 206-215
    • Hoenen, T.1    Groseth, A.2    Falzarano, D.3    Feldmann, H.4
  • 2
    • 34548512432 scopus 로고    scopus 로고
    • Filoviridae: Marburg and Ebola viruses
    • In: Knipe DM, Howley PM, eds, Philadelphia: Lippincott Williams and Williams
    • Sanchez A, Geisbert TW, Feldmann H (2007) Filoviridae: Marburg and Ebola viruses. In: Knipe DM, Howley PM, eds. Fields virology. Philadelphia: Lippincott Williams and Williams. pp 1409-1448.
    • (2007) Fields virology , pp. 1409-1448
    • Sanchez, A.1    Geisbert, T.W.2    Feldmann, H.3
  • 4
    • 0018104527 scopus 로고
    • Ebola haemorrhagic fever in Zaire, 1976
    • Johnson KM (1978) Ebola haemorrhagic fever in Zaire, 1976. Bull World Health Organ 56: 271-293.
    • (1978) Bull World Health Organ , vol.56 , pp. 271-293
    • Johnson, K.M.1
  • 5
    • 0033035134 scopus 로고    scopus 로고
    • The reemergence of Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995
    • Khan AS, Tshioko FK, Heymann DL, Le Guenno B, Nabeth P, et al. (1999) The reemergence of Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995. J Infect Dis 179: S76-S86.
    • (1999) J Infect Dis , vol.179
    • Khan, A.S.1    Tshioko, F.K.2    Heymann, D.L.3    Le Guenno, B.4    Nabeth, P.5
  • 6
    • 0033066467 scopus 로고    scopus 로고
    • Ebola hemorrhagic fever outbreaks in Gabon, 1994-1997: Epidemiologic and Health control issues
    • Georges AJ, Leroy EM, Renaut AA, Tevi Benissan C, Nabias RJ, et al. (1999) Ebola hemorrhagic fever outbreaks in Gabon, 1994-1997: Epidemiologic and Health control issues. J Infect Dis 179: S65-S75.
    • (1999) J Infect Dis , vol.179
    • Georges, A.J.1    Leroy, E.M.2    Renaut, A.A.3    Tevi Benissan, C.4    Nabias, R.J.5
  • 7
    • 9144230635 scopus 로고    scopus 로고
    • Multiple Ebola virus transmission events and rapid decline of central african wildlife
    • Leroy EM, Rouquet P, Formenty P, Souquière S, Kilbourne A, et al. (2004) Multiple Ebola virus transmission events and rapid decline of central african wildlife. Science 303: 387-390.
    • (2004) Science , vol.303 , pp. 387-390
    • Leroy, E.M.1    Rouquet, P.2    Formenty, P.3    Souquière, S.4    Kilbourne, A.5
  • 8
    • 33646749925 scopus 로고    scopus 로고
    • Detection of Ebola virus in oral fluid specimens during outbreaks of Ebola virus hemorrhagic fever in the Republic of Congo
    • Formenty P, Leroy EM, Epelboin A, Libama F, Lenzi M, et al. (2006) Detection of Ebola virus in oral fluid specimens during outbreaks of Ebola virus hemorrhagic fever in the Republic of Congo. Clin Infect Dis 42: 1521-1526.
    • (2006) Clin Infect Dis , vol.42 , pp. 1521-1526
    • Formenty, P.1    Leroy, E.M.2    Epelboin, A.3    Libama, F.4    Lenzi, M.5
  • 9
    • 36749025693 scopus 로고    scopus 로고
    • Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants
    • Wittmann TJ, Biek R, Hassanin A, Rouquet P, Reed P, et al. (2007) Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants. Proc Natl Acad Sci U S A 104: 17123-17127.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 17123-17127
    • Wittmann, T.J.1    Biek, R.2    Hassanin, A.3    Rouquet, P.4    Reed, P.5
  • 10
    • 0018188505 scopus 로고
    • Ebola haemorrhagic fever in Sudan, 1976
    • Smith DIH (1978) Ebola haemorrhagic fever in Sudan, 1976. Bull World Health Organ 56: 247-270.
    • (1978) Bull World Health Organ , vol.56 , pp. 247-270
    • Smith, D.I.H.1
  • 11
    • 0021068190 scopus 로고
    • Ebola virus disease in southern Sudan: Hospital dissemination and intrafamilial spread
    • Baron RC, McCormick JB, Zubeir OA (1983) Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread. Bull World Health Organ 61: 997-1003.
    • (1983) Bull World Health Organ , vol.61 , pp. 997-1003
    • Baron, R.C.1    McCormick, J.B.2    Zubeir, O.A.3
  • 12
    • 33748338297 scopus 로고    scopus 로고
    • Ebola haemorrhagic fever in south Sudan - update
    • World Health Organization
    • World Health Organization (2004) Ebola haemorrhagic fever in south Sudan - update. Wkly Epidemiol Rec 79: 253.
    • (2004) Wkly Epidemiol Rec , vol.79 , pp. 253
  • 13
    • 33745429598 scopus 로고    scopus 로고
    • Ebola outbreak in Uganda
    • Centers for Disease Control
    • Centers for Disease Control (2001) Ebola outbreak in Uganda. Morb Mortal Wkly Rep 50: 73-77.
    • (2001) Morb Mortal Wkly Rep , vol.50 , pp. 73-77
  • 15
    • 0029648688 scopus 로고
    • Isolation and partial characterisation of a new strain of Ebola
    • Le Guenno B, Formenty P, Wyers M, Gounon P, Walker F, et al. (1995) Isolation and partial characterisation of a new strain of Ebola. The Lancet 345: 1271-1274.
    • (1995) The Lancet , vol.345 , pp. 1271-1274
    • Le Guenno, B.1    Formenty, P.2    Wyers, M.3    Gounon, P.4    Walker, F.5
  • 16
    • 0033000976 scopus 로고    scopus 로고
    • Human infection due to Ebola virus, subtype côte d'ivoire: Clinical and biologic presentation
    • Formenty P, Hatz C, Le Guenno B, Stoll A, Rogenmoser P, et al. (1999) Human infection due to Ebola virus, subtype côte d'ivoire: clinical and biologic presentation. J Infect Dis 179: S48-S53.
    • (1999) J Infect Dis , vol.179
    • Formenty, P.1    Hatz, C.2    Le Guenno, B.3    Stoll, A.4    Rogenmoser, P.5
  • 17
    • 57149120780 scopus 로고    scopus 로고
    • Newly discovered ebola virus associated with hemorrhagic Fever outbreak in Uganda
    • Towner JS, Sealy TK, Khristova ML, Albarino CG, Conlan S, et al. (2008) Newly discovered ebola virus associated with hemorrhagic Fever outbreak in Uganda. PLoS Pathog 4: e1000212.
    • (2008) PLoS Pathog , vol.4
    • Towner, J.S.1    Sealy, T.K.2    Khristova, M.L.3    Albarino, C.G.4    Conlan, S.5
  • 18
  • 19
    • 0033030811 scopus 로고    scopus 로고
    • Ebola (subtype Reston) virus among quarantined nonhuman primates recently imported from the Philippines to the United States
    • Rollin PE, Williams RJ, Bressler DS, Pearson S, Cottingham M, et al. (1999) Ebola (subtype Reston) virus among quarantined nonhuman primates recently imported from the Philippines to the United States. J Infect Dis 179: S108-S114.
    • (1999) J Infect Dis , vol.179
    • Rollin, P.E.1    Williams, R.J.2    Bressler, D.S.3    Pearson, S.4    Cottingham, M.5
  • 22
    • 0029872239 scopus 로고    scopus 로고
    • Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages
    • Feldmann H, Bugany H, Mahner F, Klenk HD, Drenckhahn D, et al. (1996) Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages. J Clin Invest 70: 2208-2214.
    • (1996) J Clin Invest , vol.70 , pp. 2208-2214
    • Feldmann, H.1    Bugany, H.2    Mahner, F.3    Klenk, H.D.4    Drenckhahn, D.5
  • 23
    • 0034755148 scopus 로고    scopus 로고
    • Infection and activation of monocytes by Marburg and Ebola viruses
    • Ströher U, West E, Bugany H, Klenk H-D, Schnittler H-J, et al. (2001) Infection and activation of monocytes by Marburg and Ebola viruses. J Virol 75: 11025-11033.
    • (2001) J Virol , vol.75 , pp. 11025-11033
    • Ströher, U.1    West, E.2    Bugany, H.3    Klenk, H.-D.4    Schnittler, H.-J.5
  • 24
    • 10744224131 scopus 로고    scopus 로고
    • Pathogenesis of Ebola Hemorrhagic fever in cynomolgus macaques
    • Geisbert TW, Hensley L, Larsen T, Young HA, Reed DS, et al. (2003) Pathogenesis of Ebola Hemorrhagic fever in cynomolgus macaques. Am J Pathol 163: 2347-2370.
    • (2003) Am J Pathol , vol.163 , pp. 2347-2370
    • Geisbert, T.W.1    Hensley, L.2    Larsen, T.3    Young, H.A.4    Reed, D.S.5
  • 25
    • 0347122085 scopus 로고    scopus 로고
    • Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation
    • Bosio CM, Aman MJ, Grogan C, Hogan R, Ruthel G, et al. (2003) Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation. J Infect Dis 188: 1630-1638.
    • (2003) J Infect Dis , vol.188 , pp. 1630-1638
    • Bosio, C.M.1    Aman, M.J.2    Grogan, C.3    Hogan, R.4    Ruthel, G.5
  • 26
    • 0035666691 scopus 로고    scopus 로고
    • Haematological, biochemical and coagulation changes in mice, guinea pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus
    • Bray M, Hatfill S, Hensley L, Huggins JW (2001) Haematological, biochemical and coagulation changes in mice, guinea pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus. J Comp Path 125: 243-253.
    • (2001) J Comp Path , vol.125 , pp. 243-253
    • Bray, M.1    Hatfill, S.2    Hensley, L.3    Huggins, J.W.4
  • 27
    • 0348053693 scopus 로고    scopus 로고
    • Mechanisms underlying coagulation abnormalities in Ebola hemorrhagic fever: Overexpression of tissue factor in primate monocytes/macrophages is a key event
    • Geisbert TW, Young HA, Jahrling PB, Davis KJ, Kagan E, et al. (2003) Mechanisms underlying coagulation abnormalities in Ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event. J Infect Dis 188: 1618-1629.
    • (2003) J Infect Dis , vol.188 , pp. 1618-1629
    • Geisbert, T.W.1    Young, H.A.2    Jahrling, P.B.3    Davis, K.J.4    Kagan, E.5
  • 28
    • 0348147492 scopus 로고    scopus 로고
    • Ebola hemorrhagic fever and septic shock
    • Bray M, Mahanty S (2003) Ebola hemorrhagic fever and septic shock. J Infect Dis 188: 1613-1617.
    • (2003) J Infect Dis , vol.188 , pp. 1613-1617
    • Bray, M.1    Mahanty, S.2
  • 29
    • 0345445900 scopus 로고    scopus 로고
    • Pathogenesis of Ebola hemorrhagic fever in primate models: Evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells
    • Geisbert TW, Young HA, Jahrling PB, Davis KJ, Larsen T, et al. (2003) Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells. Am J Pathol 163: 2371-2382.
    • (2003) Am J Pathol , vol.163 , pp. 2371-2382
    • Geisbert, T.W.1    Young, H.A.2    Jahrling, P.B.3    Davis, K.J.4    Larsen, T.5
  • 30
    • 0034006617 scopus 로고    scopus 로고
    • Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses
    • Geisbert TW, Hensley LE, Gibb TR, Steele KE, Jaax NK, et al. (2000) Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses. Lab Invest 80: 171-186.
    • (2000) Lab Invest , vol.80 , pp. 171-186
    • Geisbert, T.W.1    Hensley, L.E.2    Gibb, T.R.3    Steele, K.E.4    Jaax, N.K.5
  • 31
    • 0035659667 scopus 로고    scopus 로고
    • Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice
    • Gibb TR, Bray M, Geisbert TW, Steele KE, Kell WM, et al. (2001) Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice. J Comp Path 125: 233-242.
    • (2001) J Comp Path , vol.125 , pp. 233-242
    • Gibb, T.R.1    Bray, M.2    Geisbert, T.W.3    Steele, K.E.4    Kell, W.M.5
  • 32
    • 0036498098 scopus 로고    scopus 로고
    • Proinflammatory response during Ebola virus infection of primate models: Possible involvement of the tumor necrosis factor receptor superfamily
    • Hensley L, Young HA, Jahrling PB, Geisbert TW (2002) Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily. Immunol Letters 80: 169-179.
    • (2002) Immunol Letters , vol.80 , pp. 169-179
    • Hensley, L.1    Young, H.A.2    Jahrling, P.B.3    Geisbert, T.W.4
  • 33
    • 4544293451 scopus 로고    scopus 로고
    • Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques
    • Reed DS, Hensley LE, Geisbert JB, Jahrling PB, Geisbert TW (2004) Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques. Viral Immunol 17: 390-400.
    • (2004) Viral Immunol , vol.17 , pp. 390-400
    • Reed, D.S.1    Hensley, L.E.2    Geisbert, J.B.3    Jahrling, P.B.4    Geisbert, T.W.5
  • 34
    • 3242782481 scopus 로고    scopus 로고
    • Role of natural killer cells in innate protection against lethal ebola virus infection
    • Warfield KL, Perkins JG, Swenson DL, Deal EM, Bosio CM, et al. (2004) Role of natural killer cells in innate protection against lethal ebola virus infection. J Exp Med 200: 169-179.
    • (2004) J Exp Med , vol.200 , pp. 169-179
    • Warfield, K.L.1    Perkins, J.G.2    Swenson, D.L.3    Deal, E.M.4    Bosio, C.M.5
  • 35
    • 39749089452 scopus 로고    scopus 로고
    • The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever
    • Rubins KH, Hensley LE, Wahl-Jensen V, Daddario DiCaprio KM, Young HA, et al. (2007) The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever. Genome Biol 8: R174.
    • (2007) Genome Biol , vol.8
    • Rubins, K.H.1    Hensley, L.E.2    Wahl-Jensen, V.3    Daddario DiCaprio, K.M.4    Young, H.A.5
  • 37
    • 0032999846 scopus 로고    scopus 로고
    • A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever
    • Bray M, Davis K, Geisbert T, Schmaljohn C, Huggins J (1998) A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J Infect Dis 179: 248-258.
    • (1998) J Infect Dis , vol.179 , pp. 248-258
    • Bray, M.1    Davis, K.2    Geisbert, T.3    Schmaljohn, C.4    Huggins, J.5
  • 40
    • 0030044732 scopus 로고    scopus 로고
    • Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure
    • Jaax NK, Davis KJ, Geisbert TJ, Vogel P, Jaax GP, et al. (1996) Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure. Arch Pathol Lab Med 120: 140-155.
    • (1996) Arch Pathol Lab Med , vol.120 , pp. 140-155
    • Jaax, N.K.1    Davis, K.J.2    Geisbert, T.J.3    Vogel, P.4    Jaax, G.P.5
  • 41
    • 0026707378 scopus 로고
    • Pathogenic potential of filoviruses: Role of geographic origin of primate host and virus strain
    • Fisher-Hoch SP, Brammer TL, Trappier SG, Hutwagner LC, Farrar BB, et al. (1992) Pathogenic potential of filoviruses: Role of geographic origin of primate host and virus strain. J Infect Dis 166: 753-763.
    • (1992) J Infect Dis , vol.166 , pp. 753-763
    • Fisher-Hoch, S.P.1    Brammer, T.L.2    Trappier, S.G.3    Hutwagner, L.C.4    Farrar, B.B.5
  • 42
  • 44
    • 0032997843 scopus 로고    scopus 로고
    • Markedly elevated levels of interferon (IFN)- c, IFN-a, Interleukin (IL)-2, IL-10, and Tumor Necrosis Factor-a associated with fatal Ebola virus infection
    • Villinger F, Rollin PE, Brar SS, Chikkala NF, Winter J, et al. (1999) Markedly elevated levels of interferon (IFN)- c, IFN-a, Interleukin (IL)-2, IL-10, and Tumor Necrosis Factor-a associated with fatal Ebola virus infection. J Infect Dis 179: S188-191.
    • (1999) J Infect Dis , vol.179
    • Villinger, F.1    Rollin, P.E.2    Brar, S.S.3    Chikkala, N.F.4    Winter, J.5
  • 45
    • 0032907635 scopus 로고    scopus 로고
    • Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
    • Baize S, Leroy EM, Georges-Courbot M-C, Capron M, Lansoud-Soukate J, et al. (1999) Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nature Med 5: 1-5.
    • (1999) Nature Med , vol.5 , pp. 1-5
    • Baize, S.1    Leroy, E.M.2    Georges-Courbot, M.-C.3    Capron, M.4    Lansoud-Soukate, J.5
  • 49
    • 77949407840 scopus 로고    scopus 로고
    • High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon
    • Becquart P, Wauquier N, Mahlakoiv T, Nkoghe D, Padilla C, et al. (2010) High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon. PLoS One 5: e9126.
    • (2010) PLoS One , vol.5
    • Becquart, P.1    Wauquier, N.2    Mahlakoiv, T.3    Nkoghe, D.4    Padilla, C.5
  • 50
    • 0032976232 scopus 로고    scopus 로고
    • Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells
    • Harcourt BH, Sanchez A, Offermann MK (1999) Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells. J Virol 73: 3491-3496.
    • (1999) J Virol , vol.73 , pp. 3491-3496
    • Harcourt, B.H.1    Sanchez, A.2    Offermann, M.K.3
  • 51
    • 0035947156 scopus 로고    scopus 로고
    • Monocyte-derived human macrophage and peripheral blood mononuclear cells infected with Ebola virus secrete MIP-1a and TNF-a and inhibit poly-IC-induced IFN-a in vitro
    • Gupta M, Mahanty S, Ahmed R, Rollin PE (2001) Monocyte-derived human macrophage and peripheral blood mononuclear cells infected with Ebola virus secrete MIP-1a and TNF-a and inhibit poly-IC-induced IFN-a in vitro. Virology 284: 20-25.
    • (2001) Virology , vol.284 , pp. 20-25
    • Gupta, M.1    Mahanty, S.2    Ahmed, R.3    Rollin, P.E.4
  • 52
    • 0037443448 scopus 로고    scopus 로고
    • Cutting edge: Impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses
    • Mahanty S, Hutchinson K, Agarwal S, McRae M, Rollin PE, et al. (2003) Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses. J Immunol 170: 2797-2801.
    • (2003) J Immunol , vol.170 , pp. 2797-2801
    • Mahanty, S.1    Hutchinson, K.2    Agarwal, S.3    McRae, M.4    Rollin, P.E.5
  • 54
    • 33644777658 scopus 로고    scopus 로고
    • Global suppression of the host antiviral response by Ebola- and Marburgviruses: Increased antagonism of the type I interferon response is associated with enhanced virulence
    • Kash JC, Muhlberger E, Carter V, Grosch M, Perwitasari O, et al. (2006) Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence. J Virol 80: 3009-3020.
    • (2006) J Virol , vol.80 , pp. 3009-3020
    • Kash, J.C.1    Muhlberger, E.2    Carter, V.3    Grosch, M.4    Perwitasari, O.5
  • 55
    • 43949091157 scopus 로고    scopus 로고
    • Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein
    • Hartman AL, Ling L, Nichol ST, Hibberd ML (2008) Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein. J Virol 82: 5348-5358.
    • (2008) J Virol , vol.82 , pp. 5348-5358
    • Hartman, A.L.1    Ling, L.2    Nichol, S.T.3    Hibberd, M.L.4
  • 57
    • 70349255932 scopus 로고    scopus 로고
    • Evasion of interferon responses by Ebola and Marburg viruses
    • Basler CF, Amarasinghe GK (2009) Evasion of interferon responses by Ebola and Marburg viruses. J Interferon Cytokine Res 29: 511-520.
    • (2009) J Interferon Cytokine Res , vol.29 , pp. 511-520
    • Basler, C.F.1    Amarasinghe, G.K.2
  • 58
    • 33646754920 scopus 로고    scopus 로고
    • Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation
    • Reid SP, Leung LW, Hartman AL, Martinez O, Shaw ML, et al. (2006) Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation. J Virol 80: 5156-5167.
    • (2006) J Virol , vol.80 , pp. 5156-5167
    • Reid, S.P.1    Leung, L.W.2    Hartman, A.L.3    Martinez, O.4    Shaw, M.L.5
  • 59
    • 37149040796 scopus 로고    scopus 로고
    • Ebola virus VP24 proteins inhibit the interaction of NP1-1 subfamily karyopherin alpha proteins with activated STAT1
    • Reid SP, Valmas C, Martinez O, Sanchez A, Basler CF (2007) Ebola virus VP24 proteins inhibit the interaction of NP1-1 subfamily karyopherin alpha proteins with activated STAT1. J Virol 81: 13469-13477.
    • (2007) J Virol , vol.81 , pp. 13469-13477
    • Reid, S.P.1    Valmas, C.2    Martinez, O.3    Sanchez, A.4    Basler, C.F.5
  • 60
    • 0037744789 scopus 로고    scopus 로고
    • The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3
    • Basler CF, Mikulasova A, Martinez-Sobrido L, Paragas J, Muhlberger E, et al. (2003) The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3. J Virol 77: 7945-7956.
    • (2003) J Virol , vol.77 , pp. 7945-7956
    • Basler, C.F.1    Mikulasova, A.2    Martinez-Sobrido, L.3    Paragas, J.4    Muhlberger, E.5
  • 61
    • 5344258197 scopus 로고    scopus 로고
    • A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virus
    • Hartman AL, Towner JS, Nichol ST (2004) A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virus. Virology 328: 177-184.
    • (2004) Virology , vol.328 , pp. 177-184
    • Hartman, A.L.1    Towner, J.S.2    Nichol, S.T.3
  • 62
    • 33646748294 scopus 로고    scopus 로고
    • Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling
    • Cardenas WB, Loo YM, Gale M, Jr., Hartman AL, Kimberlin CR, et al. (2006) Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling. J Virol 80: 5168-5178.
    • (2006) J Virol , vol.80 , pp. 5168-5178
    • Cardenas, W.B.1    Loo, Y.M.2    Gale Jr., M.3    Hartman, A.L.4    Kimberlin, C.R.5
  • 63
    • 40149109042 scopus 로고    scopus 로고
    • Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus
    • Hartman AL, Bird BH, Towner JS, Antoniadou ZA, Zaki SR, et al. (2008) Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus. J Virol 82: 2699-2704.
    • (2008) J Virol , vol.82 , pp. 2699-2704
    • Hartman, A.L.1    Bird, B.H.2    Towner, J.S.3    Antoniadou, Z.A.4    Zaki, S.R.5
  • 64
    • 63149113399 scopus 로고    scopus 로고
    • Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1
    • Prins KC, Cardenas WB, Basler CF (2009) Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1, J Virol 83: 3069-3077.
    • (2009) J Virol , vol.83 , pp. 3069-3077
    • Prins, K.C.1    Cardenas, W.B.2    Basler, C.F.3
  • 65
    • 67650866693 scopus 로고    scopus 로고
    • Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery
    • Chang TH, Kubota T, Matsuoka M, Jones S, Bradfute SB, et al. (2009) Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PLoS Pathog 5: e1000493.
    • (2009) PLoS Pathog , vol.5
    • Chang, T.H.1    Kubota, T.2    Matsuoka, M.3    Jones, S.4    Bradfute, S.B.5
  • 66
    • 33845728488 scopus 로고    scopus 로고
    • The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR
    • Feng Z, Cerveny M, Yan Z, He B (2007) The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR. J Virol 81: 182-192.
    • (2007) J Virol , vol.81 , pp. 182-192
    • Feng, Z.1    Cerveny, M.2    Yan, Z.3    He, B.4
  • 68
    • 0034066642 scopus 로고    scopus 로고
    • Apoptosis in fatal Ebola infection. Does the virus toll the bell for the immune system?
    • Baize S, Leroy EM, Mavoungou E, Fisher-Hoch SP (2000) Apoptosis in fatal Ebola infection. Does the virus toll the bell for the immune system? Apoptosis 5: 5-7.
    • (2000) Apoptosis , vol.5 , pp. 5-7
    • Baize, S.1    Leroy, E.M.2    Mavoungou, E.3    Fisher-Hoch, S.P.4
  • 70
    • 44849135333 scopus 로고    scopus 로고
    • Functional CD8+ T cell responses in lethal Ebola virus infection
    • Bradfute SB, Warfield KL, Bavari S (2008) Functional CD8+ T cell responses in lethal Ebola virus infection. J Immunol 180: 4058-4066.
    • (2008) J Immunol , vol.180 , pp. 4058-4066
    • Bradfute, S.B.1    Warfield, K.L.2    Bavari, S.3
  • 71
    • 34249741065 scopus 로고    scopus 로고
    • Ebola virus infection of human PBMCs causes massive death of macrophages, CD4 and CD8 T cell subpopulations in vitro
    • Gupta M, Spiropoulou C, Rollin PE (2007) Ebola virus infection of human PBMCs causes massive death of macrophages, CD4 and CD8 T cell subpopulations in vitro. Virology 364: 45-54.
    • (2007) Virology , vol.364 , pp. 45-54
    • Gupta, M.1    Spiropoulou, C.2    Rollin, P.E.3
  • 72
    • 0026639816 scopus 로고
    • The envelope glycoprotein of Ebola virus contains an immunosuppressive-like domain similar to oncogenic retroviruses
    • Volchkov VE, Blinov VM, Netesov SV (1992) The envelope glycoprotein of Ebola virus contains an immunosuppressive-like domain similar to oncogenic retroviruses. FEBS 305: 181-184.
    • (1992) FEBS , vol.305 , pp. 181-184
    • Volchkov, V.E.1    Blinov, V.M.2    Netesov, S.V.3
  • 73
    • 33845626928 scopus 로고    scopus 로고
    • Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses
    • Yaddanapudi K, Palacios G, Towner JS, Chen I, Sariol CA, et al. (2006) Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses. FASEB J 20: 2519-2530.
    • (2006) FASEB J , vol.20 , pp. 2519-2530
    • Yaddanapudi, K.1    Palacios, G.2    Towner, J.S.3    Chen, I.4    Sariol, C.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.