Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/Deuterium Exchange Mass Spectrometry (DXMS)

Journal of Biological Chemistry

Volumn 286, Issue 20, 2011, Pages 17889-17897

  Li, Sheng ^b   Tsalkova, Tamara ^a   White, Mark A ^a   Mei, Fang C ^a   Liu, Tong ^b   Wang, Daphne ^b   Woods Jr , Virgil L ^b   Cheng, Xiaodong ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATORS; AMIDE HYDROGENS; BINDING DOMAIN; C TERMINUS; CATALYTIC CORE; CONFORMATIONAL CHANGE; CONFORMATIONAL DYNAMICS; DEUTERIUM EXCHANGE; EFFECTOR BINDING; GUANINE NUCLEOTIDE EXCHANGE FACTORS; IN-VIVO; INTRACELLULAR CAMP; INTRACELLULAR PROCESS; LIGAND-BINDING SITES; PEPTIDE AMIDES; SECOND MESSENGER; STERIC HINDRANCES; STRUCTURAL MOTIFS; SUBCELLULAR TARGETING;

AMIDES; BINDING SITES; CRYSTAL STRUCTURE; DEUTERIUM; DYNAMICS; ENZYME ACTIVITY; MASS SPECTROMETRY;

FETAL MONITORING;

DISHEVELLED PROTEIN; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP 2; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PLECKSTRIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; FRAGMENTATION REACTION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; DEUTERIUM EXCHANGE MEASUREMENT; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TELOMERE-BINDING PROTEINS;

EID: 79955961854     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.224535     Document Type: Article

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