Genetic deletion of p21(WAF1) enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis

Cancer Research

Volumn 59, Issue 9, 1999, Pages 2050-2054

  Weinberg, Wendy C ^a   Fernandez Salas, Ester ^b   Morgan, David L ^b   Shalizi, Aryaman ^a   Mirosh, Elena ^d   Stanulis, Eric ^d   Deng, Chuxia ^c   Hennings, Henry ^b   Yuspa, Stuart H ^b  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d ROW Sciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; 7,12 DIMETHYLBENZ[A]ANTHRACENE; BIOLOGICAL MARKER; CARCINOGEN; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; DIFFERENTIATION ANTIGEN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INHIBITION; GENE DELETION; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; SKIN CARCINOGENESIS; ANIMAL; CELL DIVISION; CHEMICALLY INDUCED DISORDER; COCARCINOGENESIS; COMPARATIVE STUDY; DISEASE COURSE; DRUG EFFECT; EPIDERMIS; GENETICS; GENOTYPE; HYPERPLASIA; MITOSIS INDEX; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTIGENS, DIFFERENTIATION; BIOLOGICAL MARKERS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; COCARCINOGENESIS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DISEASE PROGRESSION; EPIDERMIS; GENE DELETION; GENES, P53; GENOTYPE; HYPERPLASIA; MICE; MICE, KNOCKOUT; MITOTIC INDEX; PAPILLOMA; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033121279     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. El-Deiry, W. S., Tokino, W. S., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
2. El-Deiry, W. S. p21/p53, cellular growth control and genomic integrity. Curr. Top. Microbiol. Immunol., 227: 121-137, 1998.
3. Weinberg, W. C., Azzoli, C. G., Chapman, K., Levine, A. J., and Yuspa, S. H. p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein. Oncogene, 10: 2271-2279, 1995.
4. Missero, C., Calautti, E., Eckner, R., Chin, J., Tsai, L. H., Livingston, D. M., and Dotto, G. P. Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc. Natl. Acad. Sci. USA, 92: 5451-5455, 1995.
5. Gervais, J. L., Seth, P., and Zhang, H. Cleavage of CDK inhibitor p21(Cip1/Waf1) by caspases is an early event during DNA damage-induced apoptosis. J. Biol. Chem., 273: 19207-19212, 1998.
6. Cip1 in muscle and other terminally differentiating cells. Science (Washington DC), 267: 1024-1027, 1995.
7. Liu, M., and Pelling, J. C. UV-B/A irradiation of mouse keratinocytes results in p53-mediated WAF/CIP1 expression. Oncogene, 10: 1955-1960, 1996.
8. Wu, Y., Huang, H., Miner, Z., and Kulesz-Martin, M. Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53. Proc. Natl. Acad. Sci. USA, 94: 8982-8987, 1997.
9. Eastham, J. A., Hall, S. J., Sehgal, I., Wang, J., Timme, T. L., Yang, G., Connell-Crowley, L., Elledge, S. J., Zhang, W. W., Harper, J. W., and Thompson, T. C. In vivo gene therapy with p53 or p21 adenovirus for prostate cancer. Cancer Res., 55: 5151-5155, 1995.
10. WAF1/CIP1 on aneuploidy and the malignant phenotype of human brain tumor cells. Oncogene, 13: 1395-1403, 1996.
11. 1 arrest and apoptosis. Cancer Res., 54: 1169-1174, 1994.
12. Ha oncogene. Cancer Res., 54: 5584-5592, 1994.
13. Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Jr., Butel, J. S., and Bradley, A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature (Lond.), 356: 215-221, 1992.
14. Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., and Weinberg, R. A. Tumor spectrum analysis in p53-mutant mice. Curr. Biol., 4: 1-7, 1994.
15. 1 checkpoint control. Cell, 82: 675-684, 1995.
16. CIP1/WAF1 does not recapitulate accelerated malignant conversion caused by p53 loss in experimental skin carcinogenesis. Oncogene, 15: 685-690, 1997
17. Reiners, J. J., Jr., and Kameshwar, P. S. Susceptibility of 129/SvEv mice in two-stage carcinogenesis protocols to 12-0-tetradecanoylphorbol-13-acetate promotion. Carcinogenesis (Lond.), 18: 593-597, 1997.
18. Kawamura, H., Strickland, J. E., and Yuspa, S. H. Association of resistance to terminal differentiation with initiation of carcinogenesis in adult mouse epidermal cells. Cancer Res. 45: 2748-2752, 1985.
19. Morgan, D., Welty, D., Glick, A., Greenhalgh, D., Hennings, H., and Yuspa, S. H. Development of an in vitro model to study carcinogen-induced neoplastic progression of initiated mouse epidermal cells. Cancer Res., 52: 3145-3156, 1992.
20. Strawhecker, J. M., and Pelling, J. C. Inhibition of mouse skin tumorigenesis by dexamethasone occurs through a Ha-ras-independent mechanism. Carcinogenesis (Lond.), 13: 2075-2080, 1992.
21. Corroyer, S., Nabeyrat, E., and Clement, A. Involvement of the cell cycle inhibitor CIP1/WAF1 in lung alveolar epithelial cell growth arrest induced by glucocorticoids. Endocrinology, 138: 3677-3685, 1997.
22. Kemp, C. J., Donehower, L. A., Bradley, A., and Balmain, A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell, 74: 813-822, 1993.
23. Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev., 10: 3065-3075, 1996.
24. Wang, X. J., Greenhalgh, D. A., Jiang, A., He, D., Zhong, L., Medina, D., Brinkley, B. R., and Roop, D. R. Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis. Oncogene, 17: 35-45, 1998.
25. Greenhalgh, D. A., Wang, X. J., Donehower, L. A., and Roop, D. R. Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor α. Cancer Res., 56: 4413-4423, 1996.
26. Li, G., Tron, V., and Ho, V. Induction of squamous cell carcinoma in p53-deficient mice after ultraviolet irradiation. J. Invest. Dermatol., 110: 72-75, 1998.
27. Di Cunto, F., Topley, G., Calautti, E., Hsiao, J., Ong, L., Seth, P. K., and Dotto, G. P. Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science (Washington DC), 280: 1069-1072, 1998.
28. Harvat, B. L., Wang, A., Seth, P., and Jetten, A. M. Up-regulation of p27Kip1, p21WAF1/Cip1 and p16Ink4a is associated with, but not sufficient for, induction of squamous differentiation. J. Cell Sci., 111: 1185-1196, 1998.