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Volumn 7, Issue 4-6, 1999, Pages 377-385

Functional role of p21 during the cellular response to stress

Author keywords

Apoptosis; Cip1; Cyclin dependent kinase inhibitor; Gene induction; Genotoxic stress; Growth arrest; p53; Sdi1; Stress response; Waf1

Indexed keywords

MESSENGER RNA; PROTEIN P21; PROTEIN P53;

EID: 0032780023     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (83)

References (61)
  • 1
    • 0029074748 scopus 로고
    • Irradiation induces WAF1 expression through a p53-independent pathway in KG-1 cells
    • Akashi, M.; Hachiya, M.; Osawa, Y.; Spinn, K.; Suzuki, G.; Koeffler, H. P. Irradiation induces WAF1 expression through a p53-independent pathway in KG-1 cells. J. Biol. Chem. 270:1 9181-19187; 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19181-19187
    • Akashi, M.1    Hachiya, M.2    Osawa, Y.3    Spinn, K.4    Suzuki, G.5    Koeffler, H.P.6
  • 3
    • 0032516898 scopus 로고    scopus 로고
    • Transcriptional activation of the p21(WAF1, CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and antiapoptotic effects on human osteoblastic cells
    • Bellido, T.; O'Brien, C. A.; Roberson, P. K.; Manolagas, S. C. Transcriptional activation of the p21(WAF1, CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and antiapoptotic effects on human osteoblastic cells. J. Biol. Chem. 273:2 1137-21144; 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 21137-21144
    • Bellido, T.1    O'Brien, C.A.2    Roberson, P.K.3    Manolagas, S.C.4
  • 4
    • 0030046274 scopus 로고    scopus 로고
    • The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells
    • Biggs, J. R.; Kudlow, J. E.; Kraft, A. S. The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells. J. Biol. Chem. 271:9 01-906; 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 901-906
    • Biggs, J.R.1    Kudlow, J.E.2    Kraft, A.S.3
  • 7
    • 0028788194 scopus 로고
    • AU-rich elements: Characterization and importance in mRNA degradation
    • Chen, C. Y.; Shyu, A. B. AU-rich elements: Characterization and importance in mRNA degradation. Trends Biochem. Sci. 20:4 65-470; 1995.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 465-470
    • Chen, C.Y.1    Shyu, A.B.2
  • 8
    • 0028899480 scopus 로고
    • Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
    • Chen, J.; Jackson, P. K.; Kirschner, M. W.; Dutta, A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374:3 86-388, 1995.
    • (1995) Nature , vol.374 , pp. 386-388
    • Chen, J.1    Jackson, P.K.2    Kirschner, M.W.3    Dutta, A.4
  • 9
    • 0030663670 scopus 로고    scopus 로고
    • Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPβ
    • Chinery, R.; Brockman, J. A.; Peeler, M. O.; Shyr, Y.; Beauchamp, R. D.; Coffey, R. J. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPβ. Nat. Med. 3:1 233-1241; 1997.
    • (1997) Nat. Med. , vol.3 , pp. 1233-1241
    • Chinery, R.1    Brockman, J.A.2    Peeler, M.O.3    Shyr, Y.4    Beauchamp, R.D.5    Coffey, R.J.6
  • 10
  • 11
    • 0028220204 scopus 로고
    • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V.; Kaufmann, W. K.; Wilson, S. J.; Tlsty, T. D.; Lees, E.; Harper, J. W.; Elledge, S. J.; Reed, S. I. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1 013-1023; 1994.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 14
    • 0032576631 scopus 로고    scopus 로고
    • WAF1 induces permanent growth arrest and enhances differentiation, but does not alter apoptosis in PC12 cells
    • WAF1 induces permanent growth arrest and enhances differentiation, but does not alter apoptosis in PC12 cells. Oncogene 16: 443-451; 1998.
    • (1998) Oncogene , vol.16 , pp. 443-451
    • Erhardt, J.A.1    Pittman, R.N.2
  • 16
    • 18144449038 scopus 로고    scopus 로고
    • DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells
    • Fukuchi, K.; Tomoyasu, S.; Nakamaki, T.; Tsuruoka, N.; Gomi, K. DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells. Biochim. Biophys. Acta 1404:4 05-411; 1997.
    • (1997) Biochim. Biophys. Acta , vol.1404 , pp. 405-411
    • Fukuchi, K.1    Tomoyasu, S.2    Nakamaki, T.3    Tsuruoka, N.4    Gomi, K.5
  • 17
    • 0033080402 scopus 로고    scopus 로고
    • Transcriptional regulation of the p21 (WAF1/CIP1) gene
    • Cartel, A. I.; Tyner, A. L. Transcriptional regulation of the p21 (WAF1/CIP1) gene. Exp. Cell Res. 246: 280-289; 1999.
    • (1999) Exp. Cell Res. , vol.246 , pp. 280-289
    • Cartel, A.I.1    Tyner, A.L.2
  • 18
    • 0030024241 scopus 로고    scopus 로고
    • 2-mediated cellular arrest and death
    • 2-mediated cellular arrest and death. Cancer Res. 56:4 75-479; 1996.
    • (1996) Cancer Res. , vol.56 , pp. 475-479
    • Gorospe, M.1    Holbrook, N.J.2
  • 22
    • 0031909865 scopus 로고    scopus 로고
    • Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system
    • Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system. Mol. Cell. Biol. 18:1 400-1407; 1998.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1400-1407
    • Gorospe, M.1    Wang, X.2    Holbrook, N.J.3
  • 23
    • 0028938367 scopus 로고
    • p53 and its implication in apoptosis
    • Gotz, C.; Montenarh, M. p53 and its implication in apoptosis. Int. J. Oncol. 6:1 129-1135; 1995.
    • (1995) Int. J. Oncol. , vol.6 , pp. 1129-1135
    • Gotz, C.1    Montenarh, M.2
  • 24
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J. W.; Adami, G. R.; Wei, N.; Keyomarsi, K.; Elledge, S. J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:8 05-816; 1993.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 25
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell, L. H.; Kastan, M. B. Cell cycle control and cancer. Science 266:1 821-1828; 1994.
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 26
    • 0030609969 scopus 로고    scopus 로고
    • IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells
    • Hobeika, A. C.; Subramaniam, P. S.; Johnson, H. M. IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells. Oncogene 14:1 165-1170; 1997.
    • (1997) Oncogene , vol.14 , pp. 1165-1170
    • Hobeika, A.C.1    Subramaniam, P.S.2    Johnson, H.M.3
  • 27
    • 0032493757 scopus 로고    scopus 로고
    • waf1 mRNA contains a conserved element in its 3′-untranslated region that is bound by the Elav-like mRNA-stabilizing proteins
    • waf1 mRNA contains a conserved element in its 3′-untranslated region that is bound by the Elav-like mRNA-stabilizing proteins. J. Biol. Chem. 273:2 0511-20516; 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20511-20516
    • Joseph, B.1    Orlian, M.2    Furneaux, H.3
  • 28
    • 0028821895 scopus 로고
    • Effects of a recombinant adenovirus expressing WAF1/ Cip1 on cell growth, cell cycle and apoptosis
    • Katayose, D.; Wersto, R.; Cowan, K. H.; Seth, P. Effects of a recombinant adenovirus expressing WAF1/ Cip1 on cell growth, cell cycle and apoptosis. Cell Growth Differ. 6:1 207-1212; 1995.
    • (1995) Cell Growth Differ. , vol.6 , pp. 1207-1212
    • Katayose, D.1    Wersto, R.2    Cowan, K.H.3    Seth, P.4
  • 29
    • 0029416970 scopus 로고
    • WAF1/Cip1 expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis
    • WAF1/Cip1 expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis. Oncogene 11:2 311-2316; 1995.
    • (1995) Oncogene , vol.11 , pp. 2311-2316
    • Kobayashi, T.1    Consoli, U.2    Andreeff, M.3    Shiku, H.4    Zhang, W.5
  • 31
    • 0032012062 scopus 로고    scopus 로고
    • Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: Role of a caspase cascade
    • 30a. Levkau, B.; Koyama, H.; Raines, E. W.; Clurman, B. E.; Herren, B.; Orth, K.; Roberts, J. M.; Ross, R. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: Role of a caspase cascade. Mol. Cell 1(4):5 53-563; 1998.
    • (1998) Mol. Cell , vol.1 , Issue.4 , pp. 553-563
    • Levkau, B.1    Koyama, H.2    Raines, E.W.3    Clurman, B.E.4    Herren, B.5    Orth, K.6    Roberts, J.M.7    Ross, R.8
  • 32
    • 0028074603 scopus 로고    scopus 로고
    • Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
    • Li, R.; Waga, S.; Hannon, G. J.; Beach, D.; Stillman, B. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371:5 34-537; 1996.
    • (1996) Nature , vol.371 , pp. 534-537
    • Li, R.1    Waga, S.2    Hannon, G.J.3    Beach, D.4    Stillman, B.5
  • 33
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S. W.; Ruley, H. E.; Jacks, T.; Housman, D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:9 57-967; 1993.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 35
    • 0029873536 scopus 로고    scopus 로고
    • Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein
    • Ma, W. J.; Cheng, S.; Campbell, C.; Wright, A.; Furneaux, H. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J. Biol. Chem. 271:8 144-8151; 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8144-8151
    • Ma, W.J.1    Cheng, S.2    Campbell, C.3    Wright, A.4    Furneaux, H.5
  • 36
    • 0028880855 scopus 로고
    • Cyclins, cyclin-dependent kinases and cdk inhibitors: Implica-tions in cell cycle control and cancer
    • MacLachlan, T. K.; Sang, N.; Giordano, A. Cyclins, cyclin-dependent kinases and cdk inhibitors: Implica-tions in cell cycle control and cancer. Crit. Rev. Eukaryot. Gene Exp. 5:1 27-156; 1995.
    • (1995) Crit. Rev. Eukaryot. Gene Exp. , vol.5 , pp. 127-156
    • MacLachlan, T.K.1    Sang, N.2    Giordano, A.3
  • 38
    • 18844480398 scopus 로고    scopus 로고
    • Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5
    • Matsumura, I.; Ishikawa, J.; Nakajima, K.; Oritani, K.; Tomiyama, Y.; Miyagawa, J.; Kato, T.; Miyazaki, H.; Matsuzawa, Y.; Kanakura, Y. Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5. Mol. Cell. Biol. 17:2 933-2943; 1997.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2933-2943
    • Matsumura, I.1    Ishikawa, J.2    Nakajima, K.3    Oritani, K.4    Tomiyama, Y.5    Miyagawa, J.6    Kato, T.7    Miyazaki, H.8    Matsuzawa, Y.9    Kanakura, Y.10
  • 40
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan, D. O. Principles of CDK regulation. Nature 374:1 31-134; 1995.
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 41
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A.; Ning, Y.; Venable, F.; Pereira-Smith, O. M.; Smith, J. R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:9 0-98; 1994.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 42
    • 0031306844 scopus 로고    scopus 로고
    • The regulation of cyclin-dependent kinase inhibitors (CKIs)
    • Peter, M. The regulation of cyclin-dependent kinase inhibitors (CKIs). Prog. Cell Cycle Res. 3:9 9-108; 1997.
    • (1997) Prog. Cell Cycle Res. , vol.3 , pp. 99-108
    • Peter, M.1
  • 44
    • 0032948143 scopus 로고    scopus 로고
    • Attenuation of WAF1/Cip1 expression by an antisense adenovirus expression vector sensitizes glioblastoma cells to apoptosis induced by chemotherapeutic agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin
    • 42a. Ruan, S.; Okcu, M. F.; Pong, R. C.; Andreeff, M.; Levin, V.; Hsieh, J. T.; Zhang, W. Attenuation of WAF1/Cip1 expression by an antisense adenovirus expression vector sensitizes glioblastoma cells to apoptosis induced by chemotherapeutic agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin. Clin. Cancer Res. 5(1):1 97-202; 1999.
    • (1999) Clin. Cancer Res. , vol.5 , Issue.1 , pp. 197-202
    • Ruan, S.1    Okcu, M.F.2    Pong, R.C.3    Andreeff, M.4    Levin, V.5    Hsieh, J.T.6    Zhang, W.7
  • 46
    • 0023058975 scopus 로고
    • A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
    • Shaw, G.; Kamen, R. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:6 59-667; 1986.
    • (1986) Cell , vol.46 , pp. 659-667
    • Shaw, G.1    Kamen, R.2
  • 47
    • 0028973212 scopus 로고
    • Waf1/Cip1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines
    • Waf1/Cip1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene 11:1 899-1905; 1995.
    • (1995) Oncogene , vol.11 , pp. 1899-1905
    • Sheikh, M.S.1    Rochefort, H.2    Garcia, M.3
  • 48
    • 0030612714 scopus 로고    scopus 로고
    • Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells
    • Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene 14:1 875-1882; 1997.
    • (1997) Oncogene , vol.14 , pp. 1875-1882
    • Sheikh, M.S.1    Chen, Y.Q.2    Smith, M.L.3    Fornace, A.J.J.4
  • 51
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waga, S.; Hannon, G. J.; Beach, D.; Stillman, B. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369:5 74-578; 1994.
    • (1994) Nature , vol.369 , pp. 574-578
    • Waga, S.1    Hannon, G.J.2    Beach, D.3    Stillman, B.4
  • 52
    • 0028849274 scopus 로고
    • p21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • Waldman, T.; Kinzler, K. W.; Vogelstein, B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55:5 187-5190; 1995.
    • (1995) Cancer Res. , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 53
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • Waldman, T.; Lengauer, C.; Kinzler, K. W.; Vogelstein, B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 831:7 13-716; 1996.
    • (1996) Nature , vol.831 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3    Vogelstein, B.4
  • 54
    • 0032527705 scopus 로고    scopus 로고
    • The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival
    • Wang, X.; Martindale, J. L.; Liu, Y.; Holbrook, N. J. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem. J. 333:2 91-300; 1998.
    • (1998) Biochem. J. , vol.333 , pp. 291-300
    • Wang, X.1    Martindale, J.L.2    Liu, Y.3    Holbrook, N.J.4
  • 55
    • 0031474756 scopus 로고    scopus 로고
    • Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice
    • Wang, Y. A.; Elson, A.; Leder, P. Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc. Natl. Acad. Sci. USA 94:1 4590-14595; 1997.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14590-14595
    • Wang, Y.A.1    Elson, A.2    Leder, P.3
  • 56
    • 0030611754 scopus 로고    scopus 로고
    • Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism
    • Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res. 57:4 703-4706; 1997.
    • (1997) Cancer Res. , vol.57 , pp. 4703-4706
    • Wouters, B.G.1    Giaccia, A.J.2    Denko, N.C.3    Brown, J.M.4
  • 58
    • 0029102010 scopus 로고
    • High levels of constitutive WAF1/Cip1 protein are associated with chemoresistance in acute myelogenous leukemia
    • Zhang, W.; Kornblau, S. M.; Kobayashi, T.; Gambel, A.; Claxton, D.; Deisseroth, A. B. High levels of constitutive WAF1/Cip1 protein are associated with chemoresistance in acute myelogenous leukemia. Clin. Cancer Res. 1:1 051-1057; 1995.
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1051-1057
    • Zhang, W.1    Kornblau, S.M.2    Kobayashi, T.3    Gambel, A.4    Claxton, D.5    Deisseroth, A.B.6
  • 59
    • 0033521889 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis
    • 56a. Zhang, Y.; Fujita, N.; Tsuruo, T. Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene 18(5):1 131-1138; 1999.
    • (1999) Oncogene , vol.18 , Issue.5 , pp. 1131-1138
    • Zhang, Y.1    Fujita, N.2    Tsuruo, T.3
  • 61
    • 0029670422 scopus 로고    scopus 로고
    • WAF1/CIP1 expression by p53-independent pathways
    • WAF1/CIP1 expression by p53-independent pathways. Oncogene 12:1 557-1564; 1996.
    • (1996) Oncogene , vol.12 , pp. 1557-1564
    • Zeng, Y.X.1    El-Deiry, W.S.2


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