Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes

Phytomedicine

Volumn 19, Issue 7, 2012, Pages 648-657

  Zhou, Xuelin ^a   Wang, Yan ^a   Or, Penelope M Y ^a   Wan, David C C ^a   Kwan, Yiu Wa ^a   Yeung, John H K ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

CYP2D6 activity; Danshen (Salvia miltiorrhiza); Dextromethorphan metabolism; Dihydrotanshinone; Human liver microsomes; Molecular docking

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; ASPARTIC ACID; CRYPTOTANSHINONE; CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DEXTRORPHAN; DIHYDROTANSHINONE; GLUTAMINE; O DEMETHYLASE; PHENYLALANINE; QUINIDINE; SALVIA MILTIORRHIZA EXTRACT; SALVIANOLIC ACID B; TANSHINONE I; TANSHINONE IIA; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME METABOLISM; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; LIVER MICROSOME; MOLECULAR DOCKING; PRIORITY JOURNAL;

AMINO ACIDS; CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; DEXTRORPHAN; DITERPENES, ABIETANE; DRUGS, CHINESE HERBAL; HERB-DRUG INTERACTIONS; HUMANS; KINETICS; MICROSOMES, LIVER; PHENANTHROLINES; PROTEIN BINDING; QUINIDINE; SALVIA MILTIORRHIZA;

SALVIA MILTIORRHIZA;

EID: 84860638612     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.01.005     Document Type: Article

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