-
1
-
-
0036896935
-
Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence
-
Paty, BW, Ryan, EA, Shapiro, AM, Lakey, JR and Robertson, RP (2002). Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 51: 3428-3434. (Pubitemid 35403446)
-
(2002)
Diabetes
, vol.51
, Issue.12
, pp. 3428-3434
-
-
Paty, B.W.1
Ryan, E.A.2
Shapiro, A.M.J.3
Lakey, J.R.T.4
Robertson, R.P.5
-
2
-
-
0033009479
-
Prospects for insulin delivery by ex-vivo somatic cell gene therapy
-
Bailey, CJ, Davies, EL and Docherty, K (1999). Prospects for insulin delivery by ex-vivo somatic cell gene therapy. J Mol Med 77: 244-249. (Pubitemid 29146227)
-
(1999)
Journal of Molecular Medicine
, vol.77
, Issue.1
, pp. 244-249
-
-
Bailey, C.J.1
Davies, E.L.2
Docherty, K.3
-
3
-
-
77649156843
-
Stem cell and gene therapies for diabetes mellitus
-
Calne, RY, Gan, SU and Lee, KO (2010). Stem cell and gene therapies for diabetes mellitus. Nat Rev Endocrinol 6: 173-177.
-
(2010)
Nat Rev Endocrinol
, vol.6
, pp. 173-177
-
-
Calne, R.Y.1
Gan, S.U.2
Lee, K.O.3
-
4
-
-
80053560933
-
Insulin-producing surrogate ß-cells from embryonic stem cells: Are we there yet?
-
Naujok, O, Burns, C, Jones, PM and Lenzen, S (2011). Insulin-producing surrogate ß-cells from embryonic stem cells: are we there yet? Mol Ther 19: 1759-1768.
-
(2011)
Mol Ther
, vol.19
, pp. 1759-1768
-
-
Naujok, O.1
Burns, C.2
Jones, P.M.3
Lenzen, S.4
-
5
-
-
0035032259
-
Hepatic insulin expression improves glycemic control in type 1 diabetic rats
-
DOI 10.1016/S0168-8227(01)00220-0, PII S0168822701002200
-
Dong, H, Morral, N, McEvoy, R, Meseck, M, Thung, SN and Woo, SL (2001). Hepatic insulin expression improves glycemic control in type 1 diabetic rats. Diabetes Res Clin Pract 52: 153-163. (Pubitemid 32385327)
-
(2001)
Diabetes Research and Clinical Practice
, vol.52
, Issue.3
, pp. 153-163
-
-
Dong, H.1
Morral, N.2
McEvoy, R.3
Meseck, M.4
Thung, S.N.5
Woo, S.L.C.6
-
6
-
-
0142010650
-
Glucoseresponsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats
-
DOI 10.1089/104303403769211628
-
Olson, DE, Paveglio, SA, Huey, PU, Porter, MH and Thulé, PM (2003). Glucoseresponsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats. Hum Gene Ther 14: 1401-1413. (Pubitemid 37268219)
-
(2003)
Human Gene Therapy
, vol.14
, Issue.15
, pp. 1401-1413
-
-
Olson, D.E.1
Paveglio, S.A.2
Huey, P.U.3
Porter, M.H.4
Thule, P.M.5
-
7
-
-
0036124978
-
Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo
-
DOI 10.1677/joe.0.1720653
-
Shaw, JA, Delday, MI, Hart, AW, Docherty, HM, Maltin, CA and Docherty, K (2002). Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo. J Endocrinol 172: 653-672. (Pubitemid 34232707)
-
(2002)
Journal of Endocrinology
, vol.172
, Issue.3
, pp. 653-672
-
-
Shaw, J.A.M.1
Delday, M.I.2
Hart, A.W.3
Docherty, H.M.4
Maltin, C.A.5
Docherty, K.6
-
8
-
-
21144484250
-
Safety and efficacy of adeno-associated viral vector-mediated insulin gene transfer via portal vein to the livers of streptozotocin-induced diabetic Sprague-Dawley rats
-
DOI 10.1002/jgm.708
-
Park, YM, Woo, S, Lee, GT, Ko, JY, Lee, Y, Zhao, ZS et al. (2005). Safety and efficacy of adeno-associated viral vector-mediated insulin gene transfer via portal vein to the livers of streptozotocin-induced diabetic Sprague-Dawley rats. J Gene Med 7: 621-629. (Pubitemid 40744528)
-
(2005)
Journal of Gene Medicine
, vol.7
, Issue.5
, pp. 621-629
-
-
Park, Y.M.1
Woo, S.2
Lee, G.T.3
Ko, J.-Y.4
Lee, Y.5
Zhao, Z.-S.6
Kim, H.J.7
Ahn, C.W.8
Cha, B.S.9
Kim, K.-S.10
Park, C.W.11
Lee, H.C.12
-
9
-
-
0036091935
-
Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats
-
Dong, H, Altomonte, J, Morral, N, Meseck, M, Thung, SN and Woo, SL (2002). Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats. Diabetes 51: 130-138. (Pubitemid 34517989)
-
(2002)
Diabetes
, vol.51
, Issue.1
, pp. 130-138
-
-
Dong, H.1
Altomonte, J.2
Morral, N.3
Meseck, M.4
Thung, S.N.5
Woo, S.L.C.6
-
10
-
-
0036328505
-
Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer
-
DOI 10.1038/sj.gt.3301746
-
Auricchio, A, Gao, GP, Yu, QC, Raper, S, Rivera, VM, Clackson, T et al. (2002). Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer. Gene Ther 9: 963-971. (Pubitemid 34812287)
-
(2002)
Gene Therapy
, vol.9
, Issue.14
, pp. 963-971
-
-
Auricchio, A.1
Gao, G.-P.2
Yu, Q.C.3
Raper, S.4
Rivera, V.M.5
Clackson, T.6
Wilson, J.M.7
-
11
-
-
33748289497
-
Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle
-
DOI 10.2337/db05-1615
-
Mas, A, Montané, J, Anguela, XM, Muñoz, S, Douar, AM, Riu, E et al. (2006). Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle. Diabetes 55: 1546-1553. (Pubitemid 44324106)
-
(2006)
Diabetes
, vol.55
, Issue.6
, pp. 1546-1553
-
-
Mas, A.1
Montane, J.2
Anguela, X.M.3
Munoz, S.4
Douar, A.M.5
Riu, E.6
Otaegui, P.7
Bosch, F.8
-
12
-
-
34547701718
-
Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy
-
DOI 10.1007/s00125-007-0722-0
-
Ren, B, O'Brien, BA, Swan, MA, Koina, ME, Nassif, N, Wei, MQ et al. (2007). Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy. Diabetologia 50: 1910-1920. (Pubitemid 47222846)
-
(2007)
Diabetologia
, vol.50
, Issue.9
, pp. 1910-1920
-
-
Ren, B.1
O'Brien, B.A.2
Swan, M.A.3
Koina, M.E.4
Nassif, N.5
Wei, M.Q.6
Simpson, A.M.7
-
13
-
-
0031743608
-
Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
-
Zufferey, R, Dull, T, Mandel, RJ, Bukovsky, A, Quiroz, D, Naldini, L et al. (1998). Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 72: 9873-9880. (Pubitemid 28520853)
-
(1998)
Journal of Virology
, vol.72
, Issue.12
, pp. 9873-9880
-
-
Zufferey, R.1
Dull, T.2
Mandel, R.J.3
Bukovsky, A.4
Quiroz, D.5
Naldini, L.6
Trono, D.7
-
14
-
-
0028064783
-
Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin
-
Groskreutz, DJ, Sliwkowski, MX and Gorman, CM (1994). Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin. J Biol Chem 269: 6241-6245. (Pubitemid 24243015)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.8
, pp. 6241-6245
-
-
Groskreutz, D.J.1
Sliwkowski, M.X.2
Gorman, C.M.3
-
15
-
-
0036713630
-
Titering lentiviral vectors: Comparison of DNA, RNA and marker expression methods
-
DOI 10.1038/sj.gt.3301731
-
Sastry, L, Johnson, T, Hobson, MJ, Smucker, B and Cornetta, K (2002). Titering lentiviral vectors: comparison of DNA, RNA and marker expression methods. Gene Ther 9: 1155-1162. (Pubitemid 34993938)
-
(2002)
Gene Therapy
, vol.9
, Issue.17
, pp. 1155-1162
-
-
Sastry, L.1
Johnson, T.2
Hobson, M.J.3
Smucker, B.4
Cornetta, K.5
-
17
-
-
0030716959
-
Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
-
DOI 10.1038/ng1197-314
-
Kafri, T, Blömer, U, Peterson, DA, Gage, FH and Verma, IM (1997). Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet 17: 314-317. (Pubitemid 27475995)
-
(1997)
Nature Genetics
, vol.17
, Issue.3
, pp. 314-317
-
-
Kafri, T.1
Blomer, U.2
Peterson, D.A.3
Gage, F.H.4
Verma, I.M.5
-
18
-
-
0033986340
-
Efficient lentiviral transduction of liver requires cell cycling in vivo
-
DOI 10.1038/71673
-
Park, F, Ohashi, K, Chiu, W, Naldini, L and Kay, MA (2000). Efficient lentiviral transduction of liver requires cell cycling in vivo. Nat Genet 24: 49-52. (Pubitemid 30041419)
-
(2000)
Nature Genetics
, vol.24
, Issue.1
, pp. 49-52
-
-
Park, F.1
Ohashi, K.2
Chiu, W.3
Naldini, L.4
Mark A, K.5
-
19
-
-
0031710033
-
A third-generation lentivirus vector with a conditional packaging system
-
Dull, T, Zufferey, R, Kelly, M, Mandel, RJ, Nguyen, M, Trono, D et al. (1998). A third-generation lentivirus vector with a conditional packaging system. J Virol 72: 8463-8471. (Pubitemid 28471781)
-
(1998)
Journal of Virology
, vol.72
, Issue.11
, pp. 8463-8471
-
-
Dull, T.1
Zufferey, R.2
Kelly, M.3
Mandel, R.J.4
Nguyen, M.5
Trono, D.6
Naldini, L.7
-
20
-
-
0034849315
-
Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo
-
DOI 10.1006/mthe.2001.0450
-
Park, F and Kay, MA (2001). Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo. Mol Ther 4: 164-173. (Pubitemid 32851279)
-
(2001)
Molecular Therapy
, vol.4
, Issue.3
, pp. 164-173
-
-
Park, F.1
Kay, M.A.2
-
21
-
-
0032978712
-
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
-
Zufferey, R, Donello, JE, Trono, D and Hope, TJ (1999). Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol 73: 2886-2892. (Pubitemid 29135675)
-
(1999)
Journal of Virology
, vol.73
, Issue.4
, pp. 2886-2892
-
-
Zufferey, R.1
Donello, J.E.2
Trono, D.3
Hope, T.J.4
-
22
-
-
0032775261
-
Human immunodeficiency virus type 1 Tat protein activates transcription factor NF-κB through the cellular interferon-inducible, double-stranded RNA- dependent protein kinase, PKR
-
Demarchi, F, Gutierrez, MI and Giacca, M (1999). Human immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKR. J Virol 73: 7080-7086. (Pubitemid 29327899)
-
(1999)
Journal of Virology
, vol.73
, Issue.8
, pp. 7080-7086
-
-
Demarchi, F.1
Gutierrez, M.I.2
Giacca, M.3
-
23
-
-
0032798589
-
HIV-1 Tat-mediated activation of glycogen synthase kinase-3β contributes to Tat-mediated neurotoxicity
-
DOI 10.1046/j.1471-4159.1999.0730578.x
-
Maggirwar, SB, Tong, N, Ramirez, S, Gelbard, HA and Dewhurst, S (1999). HIV-1 Tatmediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity. J Neurochem 73: 578-586. (Pubitemid 29339830)
-
(1999)
Journal of Neurochemistry
, vol.73
, Issue.2
, pp. 578-586
-
-
Maggirwar, S.B.1
Tong, N.2
Ramirez, S.3
Gelbard, H.A.4
Dewhurst, S.5
-
25
-
-
73449123732
-
State-of-the-art lentiviral vectors for research use: Risk assessment and biosafety recommendations
-
Pauwels, K, Gijsbers, R, Toelen, J, Schambach, A, Willard-Gallo, K, Verheust, C et al. (2009). State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations. Curr Gene Ther 9: 459-474.
-
(2009)
Curr Gene Ther
, vol.9
, pp. 459-474
-
-
Pauwels, K.1
Gijsbers, R.2
Toelen, J.3
Schambach, A.4
Willard-Gallo, K.5
Verheust, C.6
-
26
-
-
45249089262
-
Oxidative stress: The vulnerable beta-cell
-
Lenzen, S (2008). Oxidative stress: the vulnerable beta-cell. Biochem Soc Trans 36(Pt 3): 343-347.
-
(2008)
Biochem Soc Trans
, vol.36
, Issue.PART 3
, pp. 343-347
-
-
Lenzen, S.1
-
27
-
-
17944372927
-
The LEW.1AR1/Ztm-iddm rat: A new model of spontaneous insulin-dependent diabetes mellitus
-
DOI 10.1007/s001250100625
-
Lenzen, S, Tiedge, M, Elsner, M, Lortz, S, Weiss, H, Jörns, A et al. (2001). The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus. Diabetologia 44: 1189-1196. (Pubitemid 32835513)
-
(2001)
Diabetologia
, vol.44
, Issue.9
, pp. 1189-1196
-
-
Lenzen, S.1
Tiedge, M.2
Elsner, M.3
Lortz, S.4
Weiss, H.5
Jorns, A.6
Kloppel, G.7
Wedekind, D.8
Prokop, C.-M.9
Hedrich, H.J.10
-
28
-
-
21344471092
-
Immune cell infiltration, cytokine expression, and β-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat
-
DOI 10.2337/diabetes.54.7.2041
-
Jörns, A, Günther, A, Hedrich, HJ, Wedekind, D, Tiedge, M and Lenzen, S (2005). Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat. Diabetes 54: 2041-2052. (Pubitemid 40911267)
-
(2005)
Diabetes
, vol.54
, Issue.7
, pp. 2041-2052
-
-
Jorns, A.1
Gunther, A.2
Hedrich, H.-J.3
Wedekind, D.4
Tiedge, M.5
Lenzen, S.6
-
29
-
-
67349274434
-
Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes
-
Arndt, T, Wedekind, D, Weiss, H, Tiedge, M, Lenzen, S, Hedrich, HJ et al. (2009). Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes. Diabetologia 52: 1381-1390.
-
(2009)
Diabetologia
, vol.52
, pp. 1381-1390
-
-
Arndt, T.1
Wedekind, D.2
Weiss, H.3
Tiedge, M.4
Lenzen, S.5
Hedrich, H.J.6
-
30
-
-
77954898611
-
Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation
-
Jörns, A, Rath, KJ, Terbish, T, Arndt, T, Meyer Zu Vilsendorf, A, Wedekind, D et al. (2010). Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation. Endocrinology 151: 3555-3565.
-
(2010)
Endocrinology
, vol.151
, pp. 3555-3565
-
-
Jörns, A.1
Rath, K.J.2
Terbish, T.3
Arndt, T.4
Zu, M.5
Vilsendorf, A.6
Wedekind, D.7
-
31
-
-
33646597263
-
Insulin treatment in type 1 diabetes
-
Bolli, GB (2006). Insulin treatment in type 1 diabetes. Endocr Pract 12 (suppl. 1): 105-109. (Pubitemid 44963623)
-
(2006)
Endocrine Practice
, vol.12
, Issue.SUPPL. 1
, pp. 105-109
-
-
Bolli, G.B.1
-
33
-
-
58849158813
-
Islet autotransplant outcomes after total pancreatectomy: A contrast to islet allograft outcomes
-
Sutherland, DE, Gruessner, AC, Carlson, AM, Blondet, JJ, Balamurugan, AN, Reigstad, KF et al. (2008). Islet autotransplant outcomes after total pancreatectomy: a contrast to islet allograft outcomes. Transplantation 86: 1799-1802.
-
(2008)
Transplantation
, vol.86
, pp. 1799-1802
-
-
Sutherland, D.E.1
Gruessner, A.C.2
Carlson, A.M.3
Blondet, J.J.4
Balamurugan, A.N.5
Reigstad, K.F.6
-
34
-
-
51849087695
-
The clinical impact of islet transplantation
-
Fiorina, P, Shapiro, AM, Ricordi, C and Secchi, A (2008). The clinical impact of islet transplantation. Am J Transplant 8: 1990-1997.
-
(2008)
Am J Transplant
, vol.8
, pp. 1990-1997
-
-
Fiorina, P.1
Shapiro, A.M.2
Ricordi, C.3
Secchi, A.4
-
35
-
-
26844501322
-
Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice
-
DOI 10.1016/j.febslet.2005.09.060, PII S0014579305011786
-
Burkhardt, BR, Parker, MJ, Zhang, YC, Song, S, Wasserfall, CH and Atkinson, MA (2005). Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice. FEBS Lett 579: 5759-5764. (Pubitemid 41455660)
-
(2005)
FEBS Letters
, vol.579
, Issue.25
, pp. 5759-5764
-
-
Burkhardt, B.R.1
Parker, M.J.2
Zhang, Y.C.3
Song, S.4
Wasserfall, C.H.5
Atkinson, M.A.6
-
36
-
-
43049129930
-
Glucose-and metabolically regulated hepatic insulin gene therapy for diabetes
-
Hsu, PY, Kotin, RM and Yang, YW (2008). Glucose-and metabolically regulated hepatic insulin gene therapy for diabetes. Pharm Res 25: 1460-1468.
-
(2008)
Pharm Res
, vol.25
, pp. 1460-1468
-
-
Hsu, P.Y.1
Kotin, R.M.2
Yang, Y.W.3
-
37
-
-
0028303486
-
A rapid and efficient one-tube PCR-based mutagenesis technique using pfu DNA polymerase
-
Picard, V, Ersdal-Badju, E, Lu, A and Bock, SC (1994). A rapid and efficient one-tube PCR-based mutagenesis technique using Pfu DNA polymerase. Nucleic Acids Res 22: 2587-2591. (Pubitemid 24222437)
-
(1994)
Nucleic Acids Research
, vol.22
, Issue.13
, pp. 2587-2591
-
-
Picard, V.1
Ersdal-Badju, E.2
Lu, A.3
Bock, S.C.4
|