Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes

Diabetologia

Volumn 52, Issue 7, 2009, Pages 1381-1390

  Arndt, T ^a   Wedekind, D ^a   Weiss, H ^a,b   Tiedge, M ^b   Lenzen, S ^a   Hedrich, H J ^a   Jorns A ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Animal model; Cytokine expression; LEW.1AR1 iddm rat; Pancreas draining lymph nodes; Regulatory T cells; T cell transfer; Type 1 diabetes mellitus

Indexed keywords

GLUCOSE; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; IMMUNOCOMPETENT CELL; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; LEWIS RAT; LYMPH NODE; LYMPHOCYTE TRANSFER; NONHUMAN; NUDE MOUSE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; BLOOD GLUCOSE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; GENE EXPRESSION; IMMUNOPHENOTYPING; LYMPH NODES; PANCREAS; PREDIABETIC STATE; RATS; RATS, INBRED LEW; RATS, NUDE; T-LYMPHOCYTES, REGULATORY;

EID: 67349274434     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1348-1     Document Type: Article

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