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Volumn 227, Issue 8, 2012, Pages 3044-3052

The phosphoinositide 3′-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; 9 (1 ANILINOETHYL) 7 METHYL 2 MORPHOLINOPYRIDO[1,2 A]PYRIMIDIN 4 ONE; ALPHA SMOOTH MUSCLE ACTIN; CALPONIN; INTERLEUKIN 6; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 4 (5 BENZO(1,3)DIOXOL 5 YL 4 PYRIDIN 2 YL 1H IMIDAZOL 2 YL)BENZAMIDE; 4-(5-BENZO(1,3)DIOXOL-5-YL-4-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE; ADENINE; BENZAMIDE DERIVATIVE; CHROMONE DERIVATIVE; CONTRACTILE PROTEIN; DRUG DERIVATIVE; MORPHOLINE DERIVATIVE; PIK3CD PROTEIN, HUMAN; QUINAZOLINE DERIVATIVE; TGFB1 PROTEIN, HUMAN;

EID: 84860476142     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.23046     Document Type: Article
Times cited : (24)

References (54)
  • 2
    • 42149091691 scopus 로고    scopus 로고
    • Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo
    • Ali K, Camps M, Pearce WP, Ji H, Ruckle T, Kuehn N, Pasquali C, Chabert C, Rommel C, Vanhaesebroeck B. 2008. Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo. J Immunol 180: 2538-2544.
    • (2008) J Immunol , vol.180 , pp. 2538-2544
    • Ali, K.1    Camps, M.2    Pearce, W.P.3    Ji, H.4    Ruckle, T.5    Kuehn, N.6    Pasquali, C.7    Chabert, C.8    Rommel, C.9    Vanhaesebroeck, B.10
  • 5
    • 30844447198 scopus 로고    scopus 로고
    • Raised CRP levels mark metabolic and functional impairment in advanced COPD
    • Broekhuizen R, Wouters EF, Creutzberg EC, Schols AM. 2006. Raised CRP levels mark metabolic and functional impairment in advanced COPD. Thorax 61: 17-22.
    • (2006) Thorax , vol.61 , pp. 17-22
    • Broekhuizen, R.1    Wouters, E.F.2    Creutzberg, E.C.3    Schols, A.M.4
  • 9
    • 0037331234 scopus 로고    scopus 로고
    • Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching
    • Chambers RC, Leoni P, Kaminski N, Laurent GJ, Heller RA. 2003. Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching. Am J Pathol 162: 533-546.
    • (2003) Am J Pathol , vol.162 , pp. 533-546
    • Chambers, R.C.1    Leoni, P.2    Kaminski, N.3    Laurent, G.J.4    Heller, R.A.5
  • 12
    • 39849110433 scopus 로고    scopus 로고
    • IgE alone promotes human lung mast cell survival through the autocrine production of IL-6
    • Cruse G, Cockerill S, Bradding P. 2008. IgE alone promotes human lung mast cell survival through the autocrine production of IL-6. BMC Immunol 9: 2-9.
    • (2008) BMC Immunol , vol.9 , pp. 2-9
    • Cruse, G.1    Cockerill, S.2    Bradding, P.3
  • 14
    • 42449116645 scopus 로고    scopus 로고
    • Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism
    • Farghaly HS, Blagbrough IS, Medina-Tato DA, Watson ML. 2008. Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism. Mol Pharmacol 73: 1530-1537.
    • (2008) Mol Pharmacol , vol.73 , pp. 1530-1537
    • Farghaly, H.S.1    Blagbrough, I.S.2    Medina-Tato, D.A.3    Watson, M.L.4
  • 15
    • 2342460325 scopus 로고    scopus 로고
    • PI 3-kinase inhibition: A therapeutic target for respiratory disease
    • Finan PM, Thomas MJ. 2004. PI 3-kinase inhibition: A therapeutic target for respiratory disease. Biochem Soc Trans 32: 378-382.
    • (2004) Biochem Soc Trans , vol.32 , pp. 378-382
    • Finan, P.M.1    Thomas, M.J.2
  • 17
    • 0034126071 scopus 로고    scopus 로고
    • Bundle formation of smooth muscle desmin intermediate filaments by calponin and its binding site on the desmin molecule
    • Fujii T, Takagi H, Arimoto M, Ootani H, Ueeda T. 2000. Bundle formation of smooth muscle desmin intermediate filaments by calponin and its binding site on the desmin molecule. J Biochem 127: 457-465.
    • (2000) J Biochem , vol.127 , pp. 457-465
    • Fujii, T.1    Takagi, H.2    Arimoto, M.3    Ootani, H.4    Ueeda, T.5
  • 18
    • 59349086946 scopus 로고    scopus 로고
    • BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity
    • Gamell C, Osses N, Bartrons R, Ruckle T, Camps M, Rosa JL, Ventura F. 2008. BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity. J Cell Sci 121: 3960-3970.
    • (2008) J Cell Sci , vol.121 , pp. 3960-3970
    • Gamell, C.1    Osses, N.2    Bartrons, R.3    Ruckle, T.4    Camps, M.5    Rosa, J.L.6    Ventura, F.7
  • 19
    • 77957745748 scopus 로고    scopus 로고
    • TGFbeta1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: The role of Smad2/3
    • Ge Q, Moir LM, Black JL, Oliver BG, Burgess JK. 2010. TGFbeta1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: The role of Smad2/3. J Cell Physiol 225: 846-854.
    • (2010) J Cell Physiol , vol.225 , pp. 846-854
    • Ge, Q.1    Moir, L.M.2    Black, J.L.3    Oliver, B.G.4    Burgess, J.K.5
  • 20
    • 0038308424 scopus 로고    scopus 로고
    • Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells
    • Gimona M, Kaverina I, Resch GP, Vignal E, Burgstaller G. 2003. Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells. Mol Biol Cell 14: 2482-2491.
    • (2003) Mol Biol Cell , vol.14 , pp. 2482-2491
    • Gimona, M.1    Kaverina, I.2    Resch, G.P.3    Vignal, E.4    Burgstaller, G.5
  • 22
    • 33847210725 scopus 로고    scopus 로고
    • Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation
    • Gu L, Zhu YJ, Yang X, Guo ZJ, Xu WB, Tian XL. 2007. Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation. Acta Pharmacol Sin 28: 382-391.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 382-391
    • Gu, L.1    Zhu, Y.J.2    Yang, X.3    Guo, Z.J.4    Xu, W.B.5    Tian, X.L.6
  • 25
    • 78349269947 scopus 로고    scopus 로고
    • The p110alpha and p110beta isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells
    • 652098
    • Ivison SM, Khan MA, Graham NR, Shobab LA, Yao Y, Kifayet A, Sly LM, Steiner TS. 2010. The p110alpha and p110beta isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells. Mediators Inflamm 652098: 1-12.
    • (2010) Mediators Inflamm , pp. 1-12
    • Ivison, S.M.1    Khan, M.A.2    Graham, N.R.3    Shobab, L.A.4    Yao, Y.5    Kifayet, A.6    Sly, L.M.7    Steiner, T.S.8
  • 27
    • 0035577288 scopus 로고    scopus 로고
    • Calponin is required for agonist-induced signal transduction-Evidence from an antisense approach in ferret smooth muscle
    • Je HD, Gangopadhyay SS, Ashworth TD, Morgan KG. 2001. Calponin is required for agonist-induced signal transduction-Evidence from an antisense approach in ferret smooth muscle. J Physiol 537: 567-577.
    • (2001) J Physiol , vol.537 , pp. 567-577
    • Je, H.D.1    Gangopadhyay, S.S.2    Ashworth, T.D.3    Morgan, K.G.4
  • 30
    • 0141925661 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor
    • Kaplan-Albuquerque N, Garat C, Desseva C, Jones PL, Nemenoff RA. 2003. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. J Biol Chem 278: 39830-39838.
    • (2003) J Biol Chem , vol.278 , pp. 39830-39838
    • Kaplan-Albuquerque, N.1    Garat, C.2    Desseva, C.3    Jones, P.L.4    Nemenoff, R.A.5
  • 31
    • 53449101190 scopus 로고    scopus 로고
    • Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent
    • Kim HR, Gallant C, Leavis PC, Gunst SJ, Morgan KG. 2008. Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent. Am J Physiol Cell Physiol 295: C768-C778.
    • (2008) Am J Physiol Cell Physiol , vol.295
    • Kim, H.R.1    Gallant, C.2    Leavis, P.C.3    Gunst, S.J.4    Morgan, K.G.5
  • 34
    • 33645827963 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
    • Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD. 2006. Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J 20: 455-465.
    • (2006) FASEB J , vol.20 , pp. 455-465
    • Lee, K.S.1    Lee, H.K.2    Hayflick, J.S.3    Lee, Y.C.4    Puri, K.D.5
  • 35
    • 77951667667 scopus 로고    scopus 로고
    • A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
    • Marwick JA, Caramori G, Casolari P, Mazzoni F, Kirkham PA, Adcock IM, Chung KF, Papi A. 2010a. A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 125: 1146-1153.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1146-1153
    • Marwick, J.A.1    Caramori, G.2    Casolari, P.3    Mazzoni, F.4    Kirkham, P.A.5    Adcock, I.M.6    Chung, K.F.7    Papi, A.8
  • 36
    • 76349087609 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
    • Marwick JA, Chung KF, Adcock IM. 2010b. Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease. Ther Adv Respir Dis 4: 19-34.
    • (2010) Ther Adv Respir Dis , vol.4 , pp. 19-34
    • Marwick, J.A.1    Chung, K.F.2    Adcock, I.M.3
  • 40
    • 0028265170 scopus 로고
    • Calponin is localised in both the contractile apparatus and the cytoskeleton of smooth muscle cells
    • North AJ, Gimona M, Cross RA, Small JV. 1994a. Calponin is localised in both the contractile apparatus and the cytoskeleton of smooth muscle cells. J Cell Sci 107: 437-444.
    • (1994) J Cell Sci , vol.107 , pp. 437-444
    • North, A.J.1    Gimona, M.2    Cross, R.A.3    Small, J.V.4
  • 41
    • 0028196621 scopus 로고
    • Actin isoform compartments in chicken gizzard smooth muscle cells
    • North AJ, Gimona M, Lando Z, Small JV. 1994b. Actin isoform compartments in chicken gizzard smooth muscle cells. J Cell Sci 107: 445-455.
    • (1994) J Cell Sci , vol.107 , pp. 445-455
    • North, A.J.1    Gimona, M.2    Lando, Z.3    Small, J.V.4
  • 42
    • 1642501560 scopus 로고    scopus 로고
    • PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: Is p110delta the culprit?
    • Northcott CA, Hayflick JS, Watts SW. 2004. PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: Is p110delta the culprit? Hypertension 43: 885-890.
    • (2004) Hypertension , vol.43 , pp. 885-890
    • Northcott, C.A.1    Hayflick, J.S.2    Watts, S.W.3
  • 43
    • 84860426722 scopus 로고    scopus 로고
    • IL-6 from dendritic cells regulates airway hyperresponsiveness and inflammation by controlling the fate of CD4+ T cells
    • Okamoto M, Takeda K, Joetham A, Han J, Gelfand EW. 2009. IL-6 from dendritic cells regulates airway hyperresponsiveness and inflammation by controlling the fate of CD4+ T cells. Am J Respir Crit Care Med 179: A5463.
    • (2009) Am J Respir Crit Care Med , vol.179
    • Okamoto, M.1    Takeda, K.2    Joetham, A.3    Han, J.4    Gelfand, E.W.5
  • 45
    • 0037369696 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement
    • Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE. 2003b. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol 170: 2647-2654.
    • (2003) J Immunol , vol.170 , pp. 2647-2654
    • Sadhu, C.1    Masinovsky, B.2    Dick, K.3    Sowell, C.G.4    Staunton, D.E.5
  • 47
    • 4344653389 scopus 로고    scopus 로고
    • SMAD-signaling in chronic obstructive pulmonary disease: Transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke
    • Springer J, Scholz FR, Peiser C, Groneberg DA, Fischer A. 2004. SMAD-signaling in chronic obstructive pulmonary disease: Transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol Chem 385: 649-653.
    • (2004) Biol Chem , vol.385 , pp. 649-653
    • Springer, J.1    Scholz, F.R.2    Peiser, C.3    Groneberg, D.A.4    Fischer, A.5
  • 48
    • 77952919493 scopus 로고    scopus 로고
    • Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation
    • Tang Y, Urs S, Boucher J, Bernaiche T, Venkatesh D, Spicer DB, Vary CP, Liaw L. 2010. Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation. J Biol Chem 285: 17556-17563.
    • (2010) J Biol Chem , vol.285 , pp. 17556-17563
    • Tang, Y.1    Urs, S.2    Boucher, J.3    Bernaiche, T.4    Venkatesh, D.5    Spicer, D.B.6    Vary, C.P.7    Liaw, L.8
  • 51
    • 33645566960 scopus 로고    scopus 로고
    • Enhanced upregulation of smooth muscle related transcripts by TGF beta2 in asthmatic (myo) fibroblasts
    • Wicks J, Haitchi HM, Holgate ST, Davies DE, Powell RM. 2006. Enhanced upregulation of smooth muscle related transcripts by TGF beta2 in asthmatic (myo) fibroblasts. Thorax 61: 313-319.
    • (2006) Thorax , vol.61 , pp. 313-319
    • Wicks, J.1    Haitchi, H.M.2    Holgate, S.T.3    Davies, D.E.4    Powell, R.M.5
  • 52
    • 0025348420 scopus 로고
    • Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation
    • Winder SJ, Walsh MP. 1990. Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation. J Biol Chem 265: 10148-10155.
    • (1990) J Biol Chem , vol.265 , pp. 10148-10155
    • Winder, S.J.1    Walsh, M.P.2
  • 54
    • 70249103175 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta (TGF-beta) in chronic idiopathic cough
    • Xie S, Macedo P, Hew M, Nassenstein C, Lee KY, Chung KF. 2009. Expression of transforming growth factor-beta (TGF-beta) in chronic idiopathic cough. Respir Res 10: 40-49.
    • (2009) Respir Res , vol.10 , pp. 40-49
    • Xie, S.1    Macedo, P.2    Hew, M.3    Nassenstein, C.4    Lee, K.Y.5    Chung, K.F.6


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