Discovery of N-Arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide Derivatives as HCV NS5B Polymerase Inhibitors

ChemMedChem

Volumn 7, Issue 5, 2012, Pages 850-860

  Deore, Ravindra Ramesh ^a   Chen, Grace Shiahuy ^a,b   Chang, Pei Teh ^a   Chern, Ting Rong ^a,c   Lai, Shin Yu ^a   Chuang, Ming Hsieh ^b   Lin, Jung Hsin ^a,c,d   Kung, Fan Lu ^a   Chen, Chien Shu ^a   Chiou, Chun Tang ^e   Chern, Ji Wang ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b PROVIDENCE UNIVERSITY   (Taiwan)

^c RESEARCH CENTER FOR APPLIED SCIENCES   (Taiwan)

^d INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^e NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Antiviral agents; HCV NS5B polymerase; Inhibitors; Pyrophosphate mimics; Structure activity relationships

Indexed keywords

3 (BENZYLOXY) N (4 CHLOROBENZYL) 4 OXO 3,4 DIHYDROQUINAZOLIN CARBOXAMIDE; 3 (BENZYLOXY) N (4 FLUOROBENZYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; 3 (BENZYLOXY) N (4 METHOXYBENZYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; 3 HYDROXY 4 OXO N (3 PHENYLPROPYL) 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; 3 HYDROXY 4 OXO N PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; 3 HYDROXY N (4 METHOXYBENZYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; 3 HYDROXY N (4 NITROBENZYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; AMIDE; ANTIVIRUS AGENT; ETHYL 3 HYDROXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXYLATE; MAGNESIUM ION; N (2 CHLOROBENZYL) 3 HYDROXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; N (3 CHLOROBENZYL) 3 HYDROXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; N (3,4 DICHLOROBENZYL) 3 HYDROXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; N (4 AMINOBENZYL) 3 HYDROXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; N (4 CHLOROBENZYL) 3 HYDROXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; N (4 FLUOROBENZYL) 3 HYDROXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; N ARYLALKYL 3 HYDROXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE DERIVATIVE; N BENZYL 3 BENZYLOXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; N BENZYL 3 HYDROXY 4 OXO 3,4 DIHYDROQUINAZOLIN 2 CARBOXAMIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CATALYTIC DOMAIN; DRUG DISCOVERY; HEPACIVIRUS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYMERASE CHAIN REACTION; QUINAZOLINONES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84860317142     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200058     Document Type: Article

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