2-Hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid with Inbuilt β-NHydroxy-γ-keto-Acid pharmacophore as HCV NS5B polymerase inhibitors

Current Medicinal Chemistry

Volumn 19, Issue 4, 2012, Pages 613-624

  Deore, R R ^a   Chen, G S ^a,b   Chen, C S ^a,c   Chang, P T ^a   Chuang, M H ^b   Chern, T R ^a   Wang, H C ^a   Chern, J W ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b PROVIDENCE UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

diketo acid; N Hydroxy keto acid; Active site inhibitors; Hepatitis C virus; Lead compound; Metal chelation; Non structural protein 5B (NS5B) polymerase; Pharmacophore; Pyrophosphate mimic; Structure activity relationship

Indexed keywords

1 OXO 4 PHENYL 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2 AMINO 1 OXO 4 PHENYL 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2 HYDROXY 1 OXO 4 (PARA TOLYL) 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2 HYDROXY 1 OXO 4 PHENYL 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2 HYDROXY 4 (4 METHOXYPHENYL) 1 OXO 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2 METHYL 1 OXO 4 PHENYL 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 4 (4 BROMOPHENYL) 1 OXO 1H ISOCHROMENE 3 CARBOXYLIC ACID; 4 (4 BROMOPHENYL) 2 HYDROXY 1 OXO 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 4 (4 CHLOROPHENYL) 2 HYDROXY 1 OXO 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 4 (4 METHOXYPHENYL) 1 OXO 1H ISOCHROMENE 3 CARBOXYLIC ACID; 6 CHLORO 2 HYDROXY 1 OXO 4 PHENYL 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 6,7 DICHLORO 1 OXO 4 (PARA TOLYL) 1H ISOCHROMENE 3 CARBOXYLIC ACID; 6,7 DICHLORO 1 OXO 4 PHENYL 1H ISOCHROMENE 3 CARBOXYLIC ACID; 6,7 DICHLORO 2 HYDROXY 1 OXO 4 (PARA TOLYL) 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 6,7 DICHLORO 2 HYDROXY 1 OXO 4 PHENYL 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 6,7 DICHLORO 2 HYDROXY 4 (4 METHOXYPHENYL) 1 OXO 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 6,7 DICHLORO 4 (4 CHLOROPHENYL) 1 OXO 1H ISOCHROMENE 3 CARBOXYLIC ACID; 6,7 DICHLORO 4 (4 CHLOROPHENYL) 2 HYDROXY 1 OXO 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 6,7 DICHLORO 4 (4 METHOXYPHENYL) 1 OXO 1H ISOCHROMENE 3 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; METHYL 2 HYDROXY 1 OXO 4 PHENYL 1,2 DIHYDROISOQUINOLINE 3 CARBOXYLATE; NONSTRUCTURAL PROTEIN 5B; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

ANTIVIRAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GENOTYPE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE;

CARBOXYLIC ACIDS; ENZYME INHIBITORS; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84863229930     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712798918833     Document Type: Article

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