메뉴 건너뛰기




Volumn 61, Issue 5, 2012, Pages 721-732

Decreased insulin secretion in islets from protein malnourished rats is associated with impaired glutamate dehydrogenase function: Effect of leucine supplementation

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOCAPROIC ACID; AMINOOXYACETIC ACID; BETA 2 AMINOBICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; CALCIUM; EPIGALLOCATECHIN GALLATE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; INSULIN; LEUCINE; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 84860240288     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.09.012     Document Type: Article
Times cited : (11)

References (60)
  • 1
    • 0028341884 scopus 로고
    • Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene
    • P. Shashidharan, T.M. Michaelidis, and N.K. Robakis Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene J Biol Chem 269 1994 16971 16976
    • (1994) J Biol Chem , vol.269 , pp. 16971-16976
    • Shashidharan, P.1    Michaelidis, T.M.2    Robakis, N.K.3
  • 2
    • 12244298900 scopus 로고    scopus 로고
    • Molecular basis of human glutamate dehydrogenase regulation under changing energy demands
    • V. Mastorodemos, I. Zaganas, and C. Spanaki Molecular basis of human glutamate dehydrogenase regulation under changing energy demands J Neurosci Res 79 2005 65 73
    • (2005) J Neurosci Res , vol.79 , pp. 65-73
    • Mastorodemos, V.1    Zaganas, I.2    Spanaki, C.3
  • 3
    • 33644872401 scopus 로고    scopus 로고
    • In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion
    • P. Maechler, S. Carobbio, and B. Rubi In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion Int J Cell Biol 38 2006 696 709
    • (2006) Int J Cell Biol , vol.38 , pp. 696-709
    • Maechler, P.1    Carobbio, S.2    Rubi, B.3
  • 5
    • 0038403827 scopus 로고    scopus 로고
    • Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme
    • A. Plaitakis, C. Spanaki, and V. Mastorodemos Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme Neurochem Int 2003 401 410
    • (2003) Neurochem Int , pp. 401-410
    • Plaitakis, A.1    Spanaki, C.2    Mastorodemos, V.3
  • 6
    • 46349091157 scopus 로고    scopus 로고
    • Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis
    • F. Frigerio, M. Casimir, and S. Carobbio Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis Biochem Biophys Acta 1777 2008 965 972
    • (2008) Biochem Biophys Acta , vol.1777 , pp. 965-972
    • Frigerio, F.1    Casimir, M.2    Carobbio, S.3
  • 7
    • 0019133275 scopus 로고
    • L-Leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
    • A. Sener, and W.J. Malaisse l-Leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase Nature 288 1980 187 189
    • (1980) Nature , vol.288 , pp. 187-189
    • Sener, A.1    Malaisse, W.J.2
  • 8
    • 0028106823 scopus 로고
    • Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin release
    • J. Bryla, M. Michalik, and J. Nelson Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin release Metabolism 43 1994 1187 1195
    • (1994) Metabolism , vol.43 , pp. 1187-1195
    • Bryla, J.1    Michalik, M.2    Nelson, J.3
  • 9
    • 0036894314 scopus 로고    scopus 로고
    • Glutaminolysis and insulin secretion
    • A. Kelly, C. Li, and Z. Gao Glutaminolysis and insulin secretion Diabetes 51 2002 S421 S426
    • (2002) Diabetes , vol.51
    • Kelly, A.1    Li, C.2    Gao, Z.3
  • 10
    • 0036534464 scopus 로고    scopus 로고
    • Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
    • J. Fang, B.Y. Hsu, and C.M. MacMullen Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations Biochem 363 2002 81 87
    • (2002) Biochem , vol.363 , pp. 81-87
    • Fang, J.1    Hsu, B.Y.2    MacMullen, C.M.3
  • 11
    • 0033779559 scopus 로고    scopus 로고
    • Astrocyte glutamate transport: Review of properties, regulation, and physiological functions
    • C.M. Anderson, and R.A. Swanson Astrocyte glutamate transport: review of properties, regulation, and physiological functions Glia 32 2000 1 14
    • (2000) Glia , vol.32 , pp. 1-14
    • Anderson, C.M.1    Swanson, R.A.2
  • 12
    • 0032698449 scopus 로고    scopus 로고
    • Newer aspects of glutamine/glutamate metabolism: The role of acute pH changes
    • I. Nissim Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes Am J Physiol Renal Physiol 277 1999 493 497
    • (1999) Am J Physiol Renal Physiol , vol.277 , pp. 493-497
    • Nissim, I.1
  • 13
    • 33744527647 scopus 로고    scopus 로고
    • Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase
    • C. Li, A. Allen, and J. Kwagh Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase J Biol Chem 281 2006 10214 10221
    • (2006) J Biol Chem , vol.281 , pp. 10214-10221
    • Li, C.1    Allen, A.2    Kwagh, J.3
  • 14
    • 0032493123 scopus 로고    scopus 로고
    • Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene
    • C.A. Stanley, Y.K. Lieu, and B.Y. Hsu Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene N Engl J Med 338 1998 1352 1357
    • (1998) N Engl J Med , vol.338 , pp. 1352-1357
    • Stanley, C.A.1    Lieu, Y.K.2    Hsu, B.Y.3
  • 15
    • 0032777882 scopus 로고    scopus 로고
    • Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics
    • T. Yorifuji, J. Muroi, and A. Uematsu Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics Hum Genet 104 1999 476 479
    • (1999) Hum Genet , vol.104 , pp. 476-479
    • Yorifuji, T.1    Muroi, J.2    Uematsu, A.3
  • 16
    • 0017144760 scopus 로고
    • Comparison of the effects of leucines, nonmetabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase
    • E. Gylfe Comparison of the effects of leucines, nonmetabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase Acta Diabetol Lat 13 1976 20 24
    • (1976) Acta Diabetol Lat , vol.13 , pp. 20-24
    • Gylfe, E.1
  • 17
    • 1642465556 scopus 로고    scopus 로고
    • Hyperinsulinism/hyperammonemia syndrome: Insights into the regulatory role of glutamate dehydrogenase in ammonia metabolism
    • C.A. Stanley Hyperinsulinism/hyperammonemia syndrome: insights into the regulatory role of glutamate dehydrogenase in ammonia metabolism Mol Genet Metab 81 2004 S45 51
    • (2004) Mol Genet Metab , vol.81 , pp. 45-51
    • Stanley, C.A.1
  • 18
    • 0038422184 scopus 로고    scopus 로고
    • Regulatory effects of 5′-deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets
    • S.J. Yang, J.W. Huh, and M.J. Kim Regulatory effects of 5′-deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets Biochimie 85 2003 581 586
    • (2003) Biochimie , vol.85 , pp. 581-586
    • Yang, S.J.1    Huh, J.W.2    Kim, M.J.3
  • 19
    • 59449108595 scopus 로고    scopus 로고
    • Deletion of glutamate dehydrogenase in β-cells abolishes part of the insulin secretory response not required for glucose homeostasis
    • S. Carobbio, F. Frigerio, and B. Rubi Deletion of glutamate dehydrogenase in β-cells abolishes part of the insulin secretory response not required for glucose homeostasis J Biol Chem 284 2009 921 929
    • (2009) J Biol Chem , vol.284 , pp. 921-929
    • Carobbio, S.1    Frigerio, F.2    Rubi, B.3
  • 20
    • 1542374749 scopus 로고    scopus 로고
    • Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets
    • S. Carobbio, H. Ishihara, and S. Fernandez-Pascual Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets Diabetologia 47 2004 266 276
    • (2004) Diabetologia , vol.47 , pp. 266-276
    • Carobbio, S.1    Ishihara, H.2    Fernandez-Pascual, S.3
  • 21
    • 77953941543 scopus 로고    scopus 로고
    • Role of mitochondria in beta-cell function and dysfunction
    • P. Maechler, N. Li, and M. Casimir Role of mitochondria in beta-cell function and dysfunction Adv Exp Med Biol 654 2010 193 216
    • (2010) Adv Exp Med Biol , vol.654 , pp. 193-216
    • Maechler, P.1    Li, N.2    Casimir, M.3
  • 22
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • P. Maechler, and C.B. Wollheim Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis Nature 402 1999 685 689
    • (1999) Nature , vol.402 , pp. 685-689
    • Maechler, P.1    Wollheim, C.B.2
  • 23
    • 69949115837 scopus 로고    scopus 로고
    • Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion
    • M. Casimir, F.M. Lasorsa, and B. Rubi Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion J Biol Chem 284 2009 25004 25014
    • (2009) J Biol Chem , vol.284 , pp. 25004-25014
    • Casimir, M.1    Lasorsa, F.M.2    Rubi, B.3
  • 24
    • 11144354786 scopus 로고    scopus 로고
    • A signaling role of glutamine in insulin secretion
    • C. Li, C. Buettger, and H. Kwagh A signaling role of glutamine in insulin secretion J Biol Chem 279 2004 13393 13401
    • (2004) J Biol Chem , vol.279 , pp. 13393-13401
    • Li, C.1    Buettger, C.2    Kwagh, H.3
  • 25
    • 44649195062 scopus 로고    scopus 로고
    • Studies with leucine, β-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion
    • M.J. MacDonald, N.M. Hasan, and M.J. Longacre Studies with leucine, β-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion Biochim Biophys Acta 1780 2008 966 972
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 966-972
    • MacDonald, M.J.1    Hasan, N.M.2    Longacre, M.J.3
  • 26
    • 77952779747 scopus 로고    scopus 로고
    • The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion
    • M.L. Odegaard, J.W. Joseph, and M.V. Jensen The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion J Biol Chem 285 2010 16530 16537
    • (2010) J Biol Chem , vol.285 , pp. 16530-16537
    • Odegaard, M.L.1    Joseph, J.W.2    Jensen, M.V.3
  • 27
    • 0942298242 scopus 로고    scopus 로고
    • Overexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation
    • T. Anno, S. Uehara, and H. Katagiri Overexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation Am J Physiol Endocrinol Metab 286 2004 E280 E285
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Anno, T.1    Uehara, S.2    Katagiri, H.3
  • 28
    • 77955890920 scopus 로고    scopus 로고
    • Leucine metabolism in regulation of insulin secretion from pancreatic beta cells
    • J. Yang, Y. Chi, and B.R. Burkhardt Leucine metabolism in regulation of insulin secretion from pancreatic beta cells Nutr Rev 68 2010 270 279
    • (2010) Nutr Rev , vol.68 , pp. 270-279
    • Yang, J.1    Chi, Y.2    Burkhardt, B.R.3
  • 29
    • 0020319986 scopus 로고
    • Signal function of metabolism of neutral amino acids and 2-keto acids for initiation of insulin secretion
    • S. Lenzen, H. Formanek, and U. Panten Signal function of metabolism of neutral amino acids and 2-keto acids for initiation of insulin secretion J Biol Chem 257 1982 6631 6633
    • (1982) J Biol Chem , vol.257 , pp. 6631-6633
    • Lenzen, S.1    Formanek, H.2    Panten, U.3
  • 30
    • 0020571543 scopus 로고
    • Does leucine- and norleucineinduced insulin release depend on amino acid aminotransferase activity?
    • A. Sener, F. Malaisse-Lagae, and W.J. Malaisse Does leucine- and norleucineinduced insulin release depend on amino acid aminotransferase activity? J Biol Chem 258 1983 6693 6694
    • (1983) J Biol Chem , vol.258 , pp. 6693-6694
    • Sener, A.1    Malaisse-Lagae, F.2    Malaisse, W.J.3
  • 31
    • 77958541533 scopus 로고    scopus 로고
    • Transamination is required for α-ketoisocaproate but not leucine to stimulate insulin secretion
    • Y. Zhou, T.L. Jetton, and S. Goshorn Transamination is required for α-ketoisocaproate but not leucine to stimulate insulin secretion J Biol Chem 285 2010 33718 33726
    • (2010) J Biol Chem , vol.285 , pp. 33718-33726
    • Zhou, Y.1    Jetton, T.L.2    Goshorn, S.3
  • 32
    • 0032806183 scopus 로고    scopus 로고
    • Glucose regulation of glutaminolysis and its role in insulin secretion
    • Z.Y. Gao, G. Li, and H. Najafi Glucose regulation of glutaminolysis and its role in insulin secretion Diabetes 48 1999 1535 1542
    • (1999) Diabetes , vol.48 , pp. 1535-1542
    • Gao, Z.Y.1    Li, G.2    Najafi, H.3
  • 33
    • 0038071524 scopus 로고    scopus 로고
    • Distinguishing features of leucine and α-ketoisocaproate sensing in pancreatic β-cells
    • Z. Gao, R.A. Young, and G. Li Distinguishing features of leucine and α-ketoisocaproate sensing in pancreatic β-cells Endocrinology 144 2003 1949 1957
    • (2003) Endocrinology , vol.144 , pp. 1949-1957
    • Gao, Z.1    Young, R.A.2    Li, G.3
  • 34
    • 0023550060 scopus 로고
    • Repercussions of chronic protein-calorie malnutrition on glucose homeostasis in the rat
    • W. Okitolonda, S.M. Brichard, and J.C. Henquin Repercussions of chronic protein-calorie malnutrition on glucose homeostasis in the rat Diabetologia 30 1987 946 951
    • (1987) Diabetologia , vol.30 , pp. 946-951
    • Okitolonda, W.1    Brichard, S.M.2    Henquin, J.C.3
  • 35
    • 0029030958 scopus 로고
    • Impaired activity of rat pancreatic islet mitochondrial glycerophosphate dehydrogenase in protein malnutrition
    • J. Rasschaert, B. Reusens, and S. Dahri Impaired activity of rat pancreatic islet mitochondrial glycerophosphate dehydrogenase in protein malnutrition Endocrinology 136 1995 2631 2634
    • (1995) Endocrinology , vol.136 , pp. 2631-2634
    • Rasschaert, J.1    Reusens, B.2    Dahri, S.3
  • 36
    • 0030998522 scopus 로고    scopus 로고
    • Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats
    • M.A. Reis, E.M. Carneiro, and M.A. Mello Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats J Nutr 127 1997 403 410
    • (1997) J Nutr , vol.127 , pp. 403-410
    • Reis, M.A.1    Carneiro, E.M.2    Mello, M.A.3
  • 37
    • 0037371645 scopus 로고    scopus 로고
    • Decreased cholinergic stimulation of insulin secretion by islets from rat fed a low protein diet is associated with reduced protein kinase Cα expression
    • F. Ferreira, E. Filiputti, and V.C. Arantes Decreased cholinergic stimulation of insulin secretion by islets from rat fed a low protein diet is associated with reduced protein kinase Cα expression J Nutr 134 2003 695 699
    • (2003) J Nutr , vol.134 , pp. 695-699
    • Ferreira, F.1    Filiputti, E.2    Arantes, V.C.3
  • 38
    • 0347986915 scopus 로고    scopus 로고
    • Decreased insulin secretion in islets from rats fed a low protein diet is associated with a reduced PKAα expression
    • F. Ferreira, H.C.L. Barbosa, and L.F. Stoppiglia Decreased insulin secretion in islets from rats fed a low protein diet is associated with a reduced PKAα expression J Nutr 134 2004 63 67
    • (2004) J Nutr , vol.134 , pp. 63-67
    • Ferreira, F.1    Barbosa, H.C.L.2    Stoppiglia, L.F.3
  • 39
    • 39149094602 scopus 로고    scopus 로고
    • Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats
    • E. Filiputti, F. Ferreira, and K.L. Souza Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats Life Sci 82 2008 542 548
    • (2008) Life Sci , vol.82 , pp. 542-548
    • Filiputti, E.1    Ferreira, F.2    Souza, K.L.3
  • 40
    • 77950599009 scopus 로고    scopus 로고
    • Augmentation of insulin secretion by leucine supplementation in malnourished rats: Possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway
    • E. Filiputti, A. Rafacho, and E.P. Araújo Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway Metabolism 59 2010 635 644
    • (2010) Metabolism , vol.59 , pp. 635-644
    • Filiputti, E.1    Rafacho, A.2    Araújo, E.P.3
  • 41
    • 77955200333 scopus 로고    scopus 로고
    • Leucine supplementation augments insulin secretion in pancreatic islets of malnourished mice
    • A.G. Amaral, A. Rafacho, and C.A.M. Oliveira Leucine supplementation augments insulin secretion in pancreatic islets of malnourished mice Pancreas 39 2010 847 855
    • (2010) Pancreas , vol.39 , pp. 847-855
    • Amaral, A.G.1    Rafacho, A.2    Oliveira, C.A.M.3
  • 42
    • 77952384876 scopus 로고    scopus 로고
    • Preliminary report: Leucine supplementation enhances glutamate dehydrogenase expression and restores glucose-induced insulin secretion in protein-malnourished rats
    • P.M. Da Silva, C.C. Zoppi, and E. Filiputti Preliminary report: leucine supplementation enhances glutamate dehydrogenase expression and restores glucose-induced insulin secretion in protein-malnourished rats Metabolism 59 2010 911 913
    • (2010) Metabolism , vol.59 , pp. 911-913
    • Da Silva, P.M.1    Zoppi, C.C.2    Filiputti, E.3
  • 43
    • 84856733539 scopus 로고    scopus 로고
    • Taurine supplementation restores glucose and carbachol induced insulin secretion in islets from low-protein diet rats: Involvement of Ach-M3R, Synt 1 and SNAP-25 proteins
    • 10.1016/j.jnutbio.2010.12.012
    • T.M. Batista, A.R. Ribeiro, and A.G. Amaral Taurine supplementation restores glucose and carbachol induced insulin secretion in islets from low-protein diet rats: involvement of Ach-M3R, Synt 1 and SNAP-25 proteins J Nutr Biochem 2010 10.1016/j.jnutbio.2010.12.012
    • (2010) J Nutr Biochem
    • Batista, T.M.1    Ribeiro, A.R.2    Amaral, A.G.3
  • 44
    • 14644424568 scopus 로고    scopus 로고
    • Apolipoprotein C3 deficiency results in diet induced obesity and aggravated insulin resistance in mice
    • I. Duivenvoorden, B. Teusink, and P.C. Rensen Apolipoprotein C3 deficiency results in diet induced obesity and aggravated insulin resistance in mice Diabetes 54 2005 664 667
    • (2005) Diabetes , vol.54 , pp. 664-667
    • Duivenvoorden, I.1    Teusink, B.2    Rensen, P.C.3
  • 45
    • 33947618988 scopus 로고    scopus 로고
    • Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action
    • C.T. De Souza, E.P. Araújo, and L.F. Stoppiglia Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action FASEB J 21 2007 1153 1163
    • (2007) FASEB J , vol.21 , pp. 1153-1163
    • De Souza, C.T.1    Araújo, E.P.2    Stoppiglia, L.F.3
  • 47
    • 0041426728 scopus 로고    scopus 로고
    • Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway
    • M.E. Amaral, M. Ueno, and J.B. Carvalheira Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway Horm Metab Res 35 2003 282 289
    • (2003) Horm Metab Res , vol.35 , pp. 282-289
    • Amaral, M.E.1    Ueno, M.2    Carvalheira, J.B.3
  • 48
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 49
    • 63449111277 scopus 로고    scopus 로고
    • Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice
    • J.H. Chen, M.S. Martin-Gronert, and J. Tarry-Adkins Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice PLoS One 4 2009 e4950
    • (2009) PLoS One , vol.4 , pp. 4950
    • Chen, J.H.1    Martin-Gronert, M.S.2    Tarry-Adkins, J.3
  • 50
    • 0028828451 scopus 로고
    • Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists
    • S. Bordin, A.C. Boschero, and E.M. Carneiro Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists J Membr Biol 148 1995 177 184
    • (1995) J Membr Biol , vol.148 , pp. 177-184
    • Bordin, S.1    Boschero, A.C.2    Carneiro, E.M.3
  • 51
    • 23044459225 scopus 로고    scopus 로고
    • α-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice
    • M.E. Rabaglia, M.P. Gray-Keller, and B.L. Frey α-Ketoisocaproate- induced hypersecretion of insulin by islets from diabetes-susceptible mice Am J Physiol Endocrinol Metab 289 2005 E218 E224
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Rabaglia, M.E.1    Gray-Keller, M.P.2    Frey, B.L.3
  • 52
    • 0033601208 scopus 로고    scopus 로고
    • 2+ in the endoplasmic reticulum of mouse pancreatic beta cells
    • 2+ in the endoplasmic reticulum of mouse pancreatic beta cells J Biol Chem 274 1999 36883 36890
    • (1999) J Biol Chem , vol.274 , pp. 36883-36890
    • Tengholm, A.1    Hellman, B.2    Gylfe, E.3
  • 53
    • 0035145602 scopus 로고    scopus 로고
    • Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells
    • G. Xu, G. Kwon, and W.S. Cruz Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells Diabetes 50 2001 353 360
    • (2001) Diabetes , vol.50 , pp. 353-360
    • Xu, G.1    Kwon, G.2    Cruz, W.S.3
  • 54
    • 0036787462 scopus 로고    scopus 로고
    • Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells
    • M.L. McDaniel, C.A. Marshall, and K.L. Pappan Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells Diabetes 51 2002 2877 2885
    • (2002) Diabetes , vol.51 , pp. 2877-2885
    • McDaniel, M.L.1    Marshall, C.A.2    Pappan, K.L.3
  • 55
    • 33845541249 scopus 로고    scopus 로고
    • Nutrient control of insulin secretion in isolated normal human islets
    • J.C. Henquin, D. Dufrane, and M. Nenquin Nutrient control of insulin secretion in isolated normal human islets Diabetes 55 2006 3470 3477
    • (2006) Diabetes , vol.55 , pp. 3470-3477
    • Henquin, J.C.1    Dufrane, D.2    Nenquin, M.3
  • 56
    • 77952096424 scopus 로고    scopus 로고
    • Regulation of insulin secretion: Role of mitochondrial signaling
    • S. Jitrapakdee, A. Wutthisathapornchai, and J.C. Wallace Regulation of insulin secretion: role of mitochondrial signaling Diabetologia 53 2010 1019 1032
    • (2010) Diabetologia , vol.53 , pp. 1019-1032
    • Jitrapakdee, S.1    Wutthisathapornchai, A.2    Wallace, J.C.3
  • 57
    • 0034602141 scopus 로고    scopus 로고
    • Glutamate is not a messenger in insulin secretion
    • M.J. MacDonald, and L.A. Fahien Glutamate is not a messenger in insulin secretion J Biol Chem 275 2000 34025 34027
    • (2000) J Biol Chem , vol.275 , pp. 34025-34027
    • MacDonald, M.J.1    Fahien, L.A.2
  • 58
    • 0037031896 scopus 로고    scopus 로고
    • The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related
    • G. Bertrand, N. Ishiyama, and M. Nenquin The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related J Biol Chem 277 2002 32883 32891
    • (2002) J Biol Chem , vol.277 , pp. 32883-32891
    • Bertrand, G.1    Ishiyama, N.2    Nenquin, M.3
  • 59
    • 33744951873 scopus 로고    scopus 로고
    • Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice
    • C. Li, A. Matter, and A. Kelly Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice J Biol Chem 281 2006 15064 15072
    • (2006) J Biol Chem , vol.281 , pp. 15064-15072
    • Li, C.1    Matter, A.2    Kelly, A.3
  • 60
    • 0031684038 scopus 로고    scopus 로고
    • Reduced insulin secretion in response to nutrients in islets from malnourished young rats is associated with a diminished calcium uptake
    • M.Q. Latorraca, M.A.B. Reis, and E.M. Carneiro Reduced insulin secretion in response to nutrients in islets from malnourished young rats is associated with a diminished calcium uptake J Nutr 128 1998 1643 1649
    • (1998) J Nutr , vol.128 , pp. 1643-1649
    • Latorraca, M.Q.1    Reis, M.A.B.2    Carneiro, E.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.