Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations

Biochemical Journal

Volumn 363, Issue 1, 2002, Pages 81-87

  Fang, Jie ^a   Hsu, Betty Y L ^a   MacMullen, Courtney M ^a   Poncz, Mortimer ^a   Smith, Thomas J ^a   Stanley, Charles A ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Enzyme inhibitor; Gene expression regulation; Hyperammonaemia; Hyperinsulinism; Protein structure

Indexed keywords

AMINO ACIDS; ENZYME INHIBITION; ENZYMES; INSULIN; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC CONTROL;

BIOCHEMISTRY;

2 OXOGLUTARIC ACID; ADENOSINE DIPHOSPHATE; AMINO ACID; ENZYME INHIBITOR; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GUANOSINE TRIPHOSPHATE; LEUCINE; NUCLEOTIDE;

ALLOSTERISM; ARTICLE; BINDING SITE; CATALYSIS; DEAMINATION; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME ISOLATION; ENZYME PURIFICATION; ENZYME REGULATION; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HYPERAMMONEMIA; HYPERINSULINISM; INSULIN RELEASE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; ANIMALS; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GROEL PROTEIN; GROES PROTEIN; GUANOSINE TRIPHOSPHATE; HUMANS; KETOGLUTARIC ACIDS; MITOCHONDRIA; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION;

MAMMALIA;

EID: 0036534464     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3630081     Document Type: Article

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