Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid

Toxicology

Volumn 268, Issue 1-2, 2010, Pages 31-39

  Chilakapati, Jaya ^a   Wallace, Kathleen ^b   Ren, Hongzu ^b   Fricke, Michael ^b   Bailey, Kathryn ^b   Ward, William ^b   Creed, Jack ^b   Kitchin, Kirk ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Arsenic; BEAS 2B; DEGs (differentially expressed genes); Genomics; Lungs; Oxidative stress

Indexed keywords

ARSENIC DERIVATIVE; ARSINIC ACID DERIVATIVE; CYCLIN D1; DIMETHYLARSINOUS ACID; DIMETHYLTHIOARSINIC ACID; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE PEROXIDASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; MONOMETHYLARSONOUS ACID; ORGANOARSENIC DERIVATIVE; PROTEIN P53; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SERINE PROTEINASE INHIBITOR; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F2; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CHEMICAL CARCINOGENESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENOME ANALYSIS; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CARCINOGENESIS; METABOLITE; OXIDATIVE STRESS; PRIORITY JOURNAL; RNA ISOLATION; TOXICOKINETICS;

ARSENIC; ARSENICALS; BRONCHI; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENES, CDC; GENOME-WIDE ASSOCIATION STUDY; HUMANS; NF-KAPPA B; OXIDATIVE STRESS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 73749086643     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.11.018     Document Type: Article

References (57)

1. Ahmad S., Kitchin K.T., and Cullen W.R. Plasmid DNA damage caused by methylated arsenicals, ascorbic acid and human liver ferritin. Toxicol. Lett. 133 (2002) 47-57
2. Andrewes P., Kitchin K.T., and Wallace K. Dimethylarsine and trimethylarsine are potent genotoxins in vitro. Chem. Res. Toxicol. 16 (2003) 994-1003
3. Arkell R.S., Dickinson R.J., Squires M., Hayat S., Keyse S.M., and Cook S.J. DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5. Cell Signal 20 (2008) 836-843
4. Bates M.N., Smith A.H., and Hopenhayn-Rich C. Arsenic ingestion and internal cancers: a review. Am. J. Epidemiol. 135 (1992) 462-476
5. Brigelius-Flohe R. Glutathione peroxidases and redox-regulated transcription factors. Biol. Chem. 387 (2006) 1329-1335
6. Brigelius-Flohe R., and Kipp A. Glutathione peroxidases in different stages of carcinogenesis. Biochim. Biophys. Acta (2009)
7. 1/S transition and DNA replication. Cancer Cell 3 (2003) 311-316
8. Cartwright N., McMaster S.K., Sorrentino R., Paul-Clark M., Sriskandan S., Ryffel B., Quesniaux V.F., Evans T.W., and Mitchell J.A. Elucidation of toll-like receptor and adapter protein signaling in vascular dysfunction induced by gram-positive Staphylococcus aureus or gram-negative Escherichia coli. Shock 27 (2007) 40-47
9. Chen C.J., Chen C.W., Wu M.M., and Kuo T.L. Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer 66 (1992) 888-892
10. Chen H., Liu J., Zhao C.Q., Diwan B.A., Merrick B.A., and Waalkes M.P. Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation. Toxicol. Appl. Pharmacol. 175 (2001) 260-268
11. Cohen S.M., Arnold L.L., Uzvolgyi E., Cano M., St John M., Yamamoto S., Lu X., and Le X.C. Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Chem. Res. Toxicol. 15 (2002) 1150-1157
12. Dopp E., Hartmann L.M., Florea A.M., von Recklinghausen U., Pieper R., Shokouhi B., Rettenmeier A.W., Hirner A.V., and Obe G. Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells. Toxicol. Appl. Pharmacol. 201 (2004) 156-165
13. Fautz R., Husein B., and Hechenberger C. Application of the neutral red assay (NR assay) to monolayer cultures of primary hepatocytes: rapid colorimetric viability determination for the unscheduled DNA synthesis test (UDS). Mutat. Res. 253 (1991) 173-179
14. Franklin C.C., Backos D.S., Mohar I., White C.C., Forman H.J., and Kavanagh T.J. Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Mol. Aspects Med. 30 (2009) 86-98
15. Fricke M., Zeller M., Cullen W., Witkowski M., and Creed J. Dimethylthioarsinic anhydride: a standard for arsenic speciation. Anal. Chim. Acta 583 (2007) 78-83
16. Hamadeh H.K., Vargas M., Lee E., and Menzel D.B. Arsenic disrupts cellular levels of p53 and mdm2: a potential mechanism of carcinogenesis. Biochem. Biophys. Res. Commun. 263 (1999) 446-449
17. Hughes M., and Kitchin K.T. Arsenic, oxidative stress and carcinogenesis. In: Singh K. (Ed). Oxidative stress, Disease and Cancer (2006), Imperial College Press, London 825-850
18. Hughes M.F., Kenyon E.M., and Kitchin K.T. Research approaches to address uncertainties in the risk assessment of arsenic in drinking water. Toxicol. Appl. Pharmacol. (2007)
19. IARC. Some Drinking Water Disinfectants and Contaminants, including Arsenic, International Agency for Research on Cancer. Lyon, France. (2004)
20. Kitchin K.T. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol. 172 (2001) 249-261
21. Kitchin K.T., and Ahmad S. Oxidative stress as a possible mode of action for arsenic carcinogenesis. Toxicol. Lett. 137 (2003) 3-13
22. Kitchin K.T., and Wallace K. Evidence against the nuclear in situ binding of arsenicals-oxidative stress theory of arsenic carcinogenesis. Toxicol. Appl. Pharmacol. (2008)
23. Kitchin K.T., Wallace K., and Andrewes P. Some chemical properties underlying arsenic's biological activity. In: Chapell C.R. (Ed). Arsenic Exposure and Health Effects vol. V (2002), Elsevier, San Diego 345-354
24. Kligerman A.D., Doerr C.L., Tennant A.H., Harrington-Brock K., Allen J.W., Winkfield E., Poorman-Allen P., Kundu B., Funasaka K., Roop B.C., Mass M.J., and DeMarini D.M. Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations. Environ. Mol. Mutagen. 42 (2003) 192-205
25. Kuroda K., Yoshida K., Yoshimura M., Endo Y., Wanibuchi H., Fukushima S., and Endo G. Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic. Toxicol. Appl. Pharmacol. 198 (2004) 345-353
26. Lantz R.C., and Hays A.M. Role of oxidative stress in arsenic-induced toxicity. Drug Metab. Rev. 38 (2006) 791-804
27. Le X.C., Cullen W.R., and Reimer K.J. Speciation of arsenic compounds by HPLC with hydride generation atomic absorption spectrometry and inductively coupled plasma mass spectrometry detection. Talanta 41 (1994) 495-502
28. Liu S.X., Athar M., Lippai I., Waldren C., and Hei T.K. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 1643-1648
29. Mace K., Gonzalez F.J., McConnell I.R., Garner R.C., Avanti O., Harris C.C., and Pfeifer A.M. Activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2. Mol. Carcinog. 11 (1994) 65-73
30. Mass M.J., Tennant A., Roop B.C., Cullen W.R., Styblo M., Thomas D.J., and Kligerman A.D. Methylated trivalent arsenic species are genotoxic. Chem. Res. Toxicol. 14 (2001) 355-361
31. Menzel D.B., Rasmussen R.E., Lee E., Meacher D.M., Said B., Hamadeh H., Vargas M., Greene H., and Roth R.N. Human lymphocyte heme oxygenase 1 as a response biomarker to inorganic arsenic. Biochem. Biophys. Res. Commun. 250 (1998) 653-656
32. Naranmandura H., Ibata K., and Suzuki K.T. Toxicity of dimethylmonothioarsinic acid toward human epidermoid carcinoma A431 cells. Chem. Res. Toxicol. 20 (2007) 1120-1125
33. Navas-Acien A., Silbergeld E.K., Streeter R.A., Clark J.M., Burke T.A., and Guallar E. Arsenic exposure and type 2 diabetes: a systematic review of the experimental and epidemiological evidence. Environ. Health Perspect. 114 (2006) 641-648
34. NRC. Mechanisms of toxicity. Arsenic in Drinking Water (1999), National Academy Press, Washington, DC pp. 194-196
35. NRC. Arsenic in Drinking Water 2001 Update (2001), National Academy Press, Washington, DC pp. 1-225
36. NRC. Arsenic in Drinking Water 2001 Update (2001), National Academy Press, Washington, DC pp. 194-196
37. Petrick J.S., Ayala-Fierro F., Cullen W.R., Carter D.E., and Vasken Aposhian H. Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes. Toxicol. Appl. Pharmacol. 163 (2000) 203-207
38. Pi J., Qu W., Reece J.M., Kumagai Y., and Waalkes M.P. Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide. Exp. Cell Res. 290 (2003) 234-245
39. Raml R., Rumpler A., Goessler W., Vahter M., Li L., Ochi T., and Francesconi K.A. Thio-dimethylarsinate is a common metabolite in urine samples from arsenic-exposed women in Bangladesh. Toxicol. Appl. Pharmacol. 222 (2007) 374-380
40. Reddel R.R., Ke Y., Gerwin B.I., McMenamin M.G., Lechner J.F., Su R.T., Brash D.E., Park J.B., Rhim J.S., and Harris C.C. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 48 (1988) 1904-1909
41. Reddel R.R., Malan-Shibley L., Gerwin B.I., Metcalf R.A., and Harris C.C. Tumorigenicity of human mesothelial cell line transfected with EJ-ras oncogene. J. Natl. Cancer Inst. 81 (1989) 945-948
42. Rodriguez-Puebla M.L., Robles A.I., and Conti C.J. ras activity and cyclin D1 expression: an essential mechanism of mouse skin tumor development. Mol. Carcinog. 24 (1999) 1-6
43. Salazar A.M., Ostrosky-Wegman P., Menendez D., Miranda E., Garcia-Carranca A., and Rojas E. Induction of p53 protein expression by sodium arsenite. Mutat. Res. 381 (1997) 259-265
44. Sherr C.J. Cancer cell cycles. Science 274 (1996) 1672-1677
45. Smith A.H., Hopenhayn-Rich C., Bates M.N., Goeden H.M., Hertz-Picciotto I., Duggan H.M., Wood R., Kosnett M.J., and Smith M.T. Cancer risks from arsenic in drinking water. Environ. Health Perspect. 97 (1992) 259-267
46. Smith A.H., Marshall G., Yuan Y., Ferreccio C., Liaw J., von Ehrenstein O., Steinmaus C., Bates M.N., and Selvin S. Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood. Environ. Health Perspect. 114 (2006) 1293-1296
47. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., Reed W., Wang C., Cullen W.R., and Thomas D.J. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 74 (2000) 289-299
48. Taketani S., Kohno H., Yoshinaga T., and Tokunaga R. The human 32-kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase. FEBS Lett. 245 (1989) 173-176
49. Thomas D.J., Styblo M., and Lin S. The cellular metabolism and systemic toxicity of arsenic. Toxicol. Appl. Pharmacol. 176 (2001) 127-144
50. Vahter M. What are the chemical forms of arsenic in urine, and what can they tell us about exposure?. Clin. Chem. 40 (1994) 679-680
51. Vahter M. Methylation of inorganic arsenic in different mammalian species and population groups. Sci. Prog. 82 Pt 1 (1999) 69-88
52. Waalkes M.P., Liu J., Chen H., Xie Y., Achanzar W.E., Zhou Y.S., Cheng M.L., and Diwan B.A. Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero. J. Natl. Cancer Inst. 96 (2004) 466-474
53. Wang J., Chen G., and Pantopoulos K. Inhibition of transferrin receptor 1 transcription by a cell density response element. Biochem. J. 392 (2005) 383-388
54. Wilson A.C. Setting the stage for S phase. Mol. Cell 27 (2007) 176-177
55. Yih L.H., Peck K., and Lee T.C. Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment. Carcinogenesis 23 (2002) 867-876
56. Yoshida K., Kuroda K., Zhou X., Inoue Y., Date Y., Wanibuchi H., Fukushima S., and Endo G. Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats. Chem. Res. Toxicol. 16 (2003) 1124-1129
57. Zhang D., Li J., Gao J., and Huang C. c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells. Toxicol. Appl. Pharmacol. 235 (2009) 18-24