Structural model of human glucokinase in complex with glucose and ATP: Implications for the mutants that cause hypo- and hyperglycemia

Diabetes

Volumn 48, Issue 9, 1999, Pages 1698-1705

  Mahalingam, Bhuvaneshwari ^c   Cuesta Munoz, Antonio ^a   Davis, Elizabeth A ^a   Matschinsky, Franz M ^a   Harrison, Robert W ^c   Weber, Irene T ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE MAGNESIUM; ENZYME ACTIVATOR; ENZYME INHIBITOR; GLUCOKINASE; GLUCOSE; HEXOKINASE; MUTANT PROTEIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROGEN BOND; HYPERGLYCEMIA; HYPOGLYCEMIA; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; GLUCOKINASE; GLUCOSE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION;

EID: 0032880513     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.9.1698     Document Type: Article

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