Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ρ1 receptor

ACS Chemical Neuroscience

Volumn 3, Issue 4, 2012, Pages 293-301

  Yamamoto, Izumi ^a   Carland, Jane E ^b   Locock, Katherine ^b   Gavande, Navnath ^a   Absalom, Nathan ^a   Hanrahan, Jane R ^b   Allan, Robin D ^b   Johnston, Graham A R ^b   Chebib, Mary ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b University of Sydney   (Australia)

Author keywords

Conformational change; Cys loop receptor; GABA binding site; GABAC receptors; Gating

Indexed keywords

4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOCYCLOPENT 1 ENECARBOXAMIDE; ALANINE; AMIDE; CYSTEINE; SERINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG CONFORMATION; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; GENE MUTATION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; WILD TYPE;

CONFORMATIONAL CHANGE; CYS-LOOP RECEPTOR; GABA BINDING SITE; GABAC RECEPTORS; GATING;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA ANTAGONISTS; HUMANS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 84859891117     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200121r     Document Type: Article

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