An improved, versatile synthesis of the GABAC antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA)

Journal of the Chemical Society. Perkin Transactions 1

Volumn 1, Issue 19, 2001, Pages 2389-2392

  Hanrahan, Jane R ^a   Mewett, Kenneth N ^a   Chebib, Mary ^b   Burden, Peter M ^a   Johnston, Graham A R ^a  

^a University of Sydney   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; CHEMICAL BONDS; NEUROLOGY; SYNTHESIS (CHEMICAL);

SATURATED ANALOGUES;

ORGANIC ACIDS;

EID: 0034740846     PISSN: 14727781     EISSN: 13645463     Source Type: Journal    
DOI: 10.1039/b105989k     Document Type: Article

References (18)

1. M. Chebib, G.A.R. Johnston J. Med. Chem. 2000, 43, 1427.
2. M. Chebib, G.A.R. Johnston Clin. Exp. Pharmacol. Physiol. 1999, 26, 937.
3. W. Froestl, S.J. Mickel, R.G. Hall, G. Vonsprecher, D. Strub, P.A. Baumann, F. Brugger, C. Gentsch, J. Jaekel, H.R. Olpe, G. Rihs, A. Vassout, P.C. Waldmeier, H. Bittiger J. Med. Chem. 1995, 38, 3297.
4. W. Froestl, S.J. Mickel, G. Vonsprecher, P.J. Diel, R.G. Hall, L. Maier, D. Strub, V. Melillo, P.A. Baumann, R. Bernasconi, C. Gentsch, K. Hauser, J. Jaekel, G. Karlsson, K. Klebs, L. Maitre, C. Marescaux, M.F. Pozza, M. Schmutz, M.W. Steinmann, H. Vanriezen, A. Vassout, C. Mondadori, H.R. Olpe, P.C. Waldmeier, H. Bittiger J. Med. Chem. 1995, 38, 3313.
5. M. Chebib, R.J. Vandenberg, W. Froestl, G.A.R. Johnston Eur. J. Pharmacol. 1997, 329, 223.
6. D. Ragozzino, R.M. Woodward, Y. Murata, F. Eusebi, L.E. Overman, R. Miledi Mol. Pharmacol. 1996, 50, 1024.
7. M. Chebib, K.N. Mewett, G.A.R. Johnston Eur. J. Pharmacol. 1998, 357, 227.
8. G.A.R. Johnston, P.M. Burden, K.N. Mewett and M. Chebib, PCT Int. Appl., 1998, WO 9858939, CAN 130:90522.
9. The Chemistry of Organophosphorus Compounds, ed. F. R. Hartley, Wiley, New York, 1996.
10. O. Herd, A. Hessler, M. Hingst, M. Tepper, O. Stelzer J. Organomet. Chem. 1996, 522, 69.
11. S.R. Gilbertson, G.W. Starkey J. Org. Chem. 1996, 61, 2922.
12. A. Hessler, O. Stelzer J. Org. Chem. 1997, 62, 2363.
13. H.-B. Kraatz, A. Pletsch Tetrahedron: Asymmetry 2000, 11, 1617.
14. G.A. Stark, T.H. Rieimeier, M. Beller Synth. Commun. 2000, 30, 1703.
15. Y. Murata, R.M. Woodward, R. Miledi, L.E. Overman Bioorg. Med. Chem. Lett. 1996, 6, 2073.
16. J. Kehler, B. Ebert, O. Dahl, P. Krogsgaard-Larsen J. Chem. Soc., Perkin Trans. 1 1998, 3241.
17. C. Coudret Synth. Commun. 1996, 26, 3543.
18. M.J. Gallagher, M.G. Ranasinghe Phosphorus, Sulfur Silicon Relat. Elem. 1996, 115, 255.