Structural determinants for antagonist pharmacology that distinguish the ρ1 GABAC receptor from GABAA receptors

Molecular Pharmacology

Volumn 74, Issue 4, 2008, Pages 941-951

  Zhang, Jianliang ^a   Xue, Fenqin ^a   Chang, Yongchang ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 3 AMINOPROPANEPHOSPHONIC ACID; 3 AMINOPROPYL(METHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; BICUCULLINE; PHENYLALANINE; RECEPTOR SUBUNIT; TYROSINE; VALINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; GENE MUTATION; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR SENSITIVITY; STRUCTURE ANALYSIS; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; BICUCULLINE; BINDING SITES; CHLORIDE CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FEMALE; GABA ANTAGONISTS; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; ORGANOPHOSPHORUS COMPOUNDS; PATCH-CLAMP TECHNIQUES; PHOSPHINIC ACIDS; PHOSPHONIC ACIDS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; PYRIDAZINES; RATS; RECEPTORS, GABA; RECEPTORS, GABA-A; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS;

EID: 52949150747     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.048710     Document Type: Article

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