Novel cyclic phosphinic acids as GABAC ρ receptor antagonists: Design, synthesis, and pharmacology

ACS Medicinal Chemistry Letters

Volumn 2, Issue 1, 2011, Pages 11-16

  Gavande, Navnath ^a   Yamamoto, Izumi ^a   Salam, Noeris K ^b   Ai, Tu Hoa ^c   Burden, Peter M ^c   Johnston, Graham A R ^c   Hanrahan, Jane R ^a   Chebib, Mary ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b SCHRÖDINGER INC   (United States)

^c University of Sydney   (Australia)

Author keywords

Aminobutyric acid, ligand gated ion channels, GABA receptors, cyclic phosphinic acids, two electrode voltage clamp, F1 GABAC homology model

Indexed keywords

(3 AMINOCYCLOPENTANYL) N BUTYLPHOSPHINIC ACID; 1,2,5,6 TETRAHYDROPYRIDINE 4 YL METHYL PHOSPHINIC ACID; 3 (AMINO) 1 OXO 1 HYDROXY PHOSPHOLANE; 3 (GUANIDO) 1 OXO 1 HYDROXY PHOSPHOLANE; 3 AMINOPROPYLBUTYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR BLOCKING AGENT; PHOSPHINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; LIPOPHILICITY; PRIORITY JOURNAL;

EID: 78651473192     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml1001344     Document Type: Article

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