-
1
-
-
3843079723
-
A history of the study of solid tumour growth: the contribution of math-ematical modelling
-
Araujo, R. P., and McElwain, D. L. (2004). A history of the study of solid tumour growth: the contribution of math-ematical modelling. Bull. Math. Biol. 66, 1039-1091.
-
(2004)
Bull. Math. Biol.
, vol.66
, pp. 1039-1091
-
-
Araujo, R.P.1
McElwain, D.L.2
-
2
-
-
2642536176
-
Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination
-
Berezhkovskiy, L. M. (2004). Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination. J. Pharm. Sci. 93, 1628-1640.
-
(2004)
J. Pharm. Sci.
, vol.93
, pp. 1628-1640
-
-
Berezhkovskiy, L.M.1
-
3
-
-
36949025489
-
Classifying the expansion kinetics and critical surface dynamics of growing cell populations
-
Block, M., Scholl, E., and Drasdo, D. (2007). Classifying the expansion kinetics and critical surface dynamics of growing cell populations. Phys. Rev. Lett. 99, 248101.
-
(2007)
Phys. Rev. Lett.
, vol.99
, pp. 248101
-
-
Block, M.1
Scholl, E.2
Drasdo, D.3
-
4
-
-
66349123393
-
Tamoxifen metabolism and its effect on endocrine treatment of breast cancer
-
Briest, S., and Stearns, V. (2009). Tamoxifen metabolism and its effect on endocrine treatment of breast cancer. Clin. Adv. Hematol. Oncol. 7, 185-192.
-
(2009)
Clin. Adv. Hematol. Oncol.
, vol.7
, pp. 185-192
-
-
Briest, S.1
Stearns, V.2
-
5
-
-
0034613112
-
Differential feedback regulation of the MAPK cascade underlies the quanti-tative differences in EGF and NGF signalling in PC12 cells
-
Brightman, F. A., and Fell, D. A. (2000). Differential feedback regulation of the MAPK cascade underlies the quanti-tative differences in EGF and NGF signalling in PC12 cells. FEBS Lett. 482, 169-174.
-
(2000)
FEBS Lett
, vol.482
, pp. 169-174
-
-
Brightman, F.A.1
Fell, D.A.2
-
6
-
-
0242322492
-
The universal dynamics of tumor growth
-
Bru, A., Albertos, S., Luis Subiza, J., Garcia-Asenjo, J. L., and Bru, I. (2003). The universal dynamics of tumor growth. Biophys. J. 85, 2948-2961.
-
(2003)
Biophys. J.
, vol.85
, pp. 2948-2961
-
-
Bru, A.1
Albertos, S.2
Luis Subiza, J.3
Garcia-Asenjo, J.L.4
Bru, I.5
-
7
-
-
5044226336
-
Systems biology in drug dis-covery
-
Butcher, E. C., Berg, E. L., and Kunkel, E. J. (2004). Systems biology in drug dis-covery. Nat. Biotechnol. 22, 1253-1259.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1253-1259
-
-
Butcher, E.C.1
Berg, E.L.2
Kunkel, E.J.3
-
8
-
-
84866426470
-
Whole-istic biology. Science 296, 1661. Cohen, S. D., and Hindmarsh, A. C. (1996). CVODE, a stiff/nonstiff ODE solver in C
-
Chong, L., and Ray, L. B. (2002). Whole-istic biology. Science 296, 1661. Cohen, S. D., and Hindmarsh, A. C. (1996). CVODE, a stiff/nonstiff ODE solver in C. Comput. Phys. 10, 138-143.
-
(2002)
Comput. Phys.
, vol.10
, pp. 138-143
-
-
Chong, L.1
Ray, L.B.2
-
9
-
-
71149092283
-
Dynamics and variability of ERK2 response to EGF in individual living cells
-
Cohen-Saidon, C., Cohen, A. A., Sigal, A., Liron, Y., and Alon, U. (2009). Dynamics and variability of ERK2 response to EGF in individual living cells. Mol. Cell 36, 885-893.
-
(2009)
Mol. Cell
, vol.36
, pp. 885-893
-
-
Cohen-Saidon, C.1
Cohen, A.A.2
Sigal, A.3
Liron, Y.4
Alon, U.5
-
10
-
-
62549110855
-
Personalizing medicine: a systems biology perspec-tive
-
Deisboeck, T. S. (2009). Personalizing medicine: a systems biology perspec-tive. Mol. Syst. Biol. 5, 249.
-
(2009)
Mol. Syst. Biol.
, vol.5
, pp. 249
-
-
Deisboeck, T.S.1
-
11
-
-
33745599327
-
A mechanistic approach for the scaling of clearance in children
-
Edginton, A. N., Schmitt, W., Voith, B., and Willmann, S. (2006a). A mechanistic approach for the scaling of clearance in children. Clin. Pharmacokinet. 45, 683-704.
-
(2006)
Clin. Pharmacokinet.
, vol.45
, pp. 683-704
-
-
Edginton, A.N.1
Schmitt, W.2
Voith, B.3
Willmann, S.4
-
12
-
-
33646123064
-
Application ofphysiology-based pharmacokinetic and pharmacodynamic modeling to individualized target-controlled propofol infusions
-
Edginton, A. N., Schmitt, W., and Willmann, S. (2006b). Application ofphysiology-based pharmacokinetic and pharmacodynamic modeling to individualized target-controlled propofol infusions. Adv. Ther. 23, 143-158.
-
(2006)
Adv. Ther.
, vol.23
, pp. 143-158
-
-
Edginton, A.N.1
Schmitt, W.2
Willmann, S.3
-
13
-
-
33745584148
-
Development and evaluation of a generic physiologi-cally based pharmacokinetic model for children
-
Edginton, A. N., Schmitt, W., and Willmann, S. (2006c). Development and evaluation of a generic physiologi-cally based pharmacokinetic model for children. Clin. Pharmacokinet. 45, 1013-1034.
-
(2006)
Clin. Pharmacokinet.
, vol.45
, pp. 1013-1034
-
-
Edginton, A.N.1
Schmitt, W.2
Willmann, S.3
-
14
-
-
52649130373
-
Whole body physiologically-based pharma-cokinetic models: their use in clinical drug development
-
Edginton, A. N., Theil, F. P., Schmitt, W., and Willmann, S. (2008). Whole body physiologically-based pharma-cokinetic models: their use in clinical drug development. Expert Opin. Drug Metab. Toxicol. 4, 1143-1152.
-
(2008)
Expert Opin. Drug Metab. Toxicol.
, vol.4
, pp. 1143-1152
-
-
Edginton, A.N.1
Theil, F.P.2
Schmitt, W.3
Willmann, S.4
-
15
-
-
52649085416
-
Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis
-
Edginton, A. N., and Willmann, S. (2008). Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis. Clin. Pharmacokinet. 47, 743-752.
-
(2008)
Clin. Pharmacokinet.
, vol.47
, pp. 743-752
-
-
Edginton, A.N.1
Willmann, S.2
-
16
-
-
0037119587
-
Stochastic gene expression in a single cell
-
Elowitz, M. B., Levine, A. J., Siggia, E. D., and Swain, P. S. (2002). Stochastic gene expression in a single cell. Science 297, 1183-1186.
-
(2002)
Science
, vol.297
, pp. 1183-1186
-
-
Elowitz, M.B.1
Levine, A.J.2
Siggia, E.D.3
Swain, P.S.4
-
17
-
-
73449088412
-
Physiologically based phar-macokinetics (PBPK)
-
Espie, P., Tytgat, D., Sargentini-Maier, M. L., Poggesi, I., and Watelet, J. B. (2009). Physiologically based phar-macokinetics (PBPK). Drug Metab. Rev. 41, 391-407.
-
(2009)
Drug Metab. Rev.
, vol.41
, pp. 391-407
-
-
Espie, P.1
Tytgat, D.2
Sargentini-Maier, M.L.3
Poggesi, I.4
Watelet, J.B.5
-
18
-
-
0017198676
-
On the growth and stability of cell cultures and solid tumors
-
Greenspan, H. P. (1976). On the growth and stability of cell cultures and solid tumors. J. Theor. Biol. 56, 229-242.
-
(1976)
J. Theor. Biol.
, vol.56
, pp. 229-242
-
-
Greenspan, H.P.1
-
19
-
-
0015989446
-
A linear steady-state treatment of enzymatic chains. General properties, control and effector strength
-
Heinrich, R., and Rapoport, T. A. (1974). A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur. J. Biochem. 42, 89-95.
-
(1974)
Eur. J. Biochem.
, vol.42
, pp. 89-95
-
-
Heinrich, R.1
Rapoport, T.A.2
-
21
-
-
79951964385
-
Systems biology and integrative physiologi-cal modeling
-
doi: 10.1113/ jphysiol.2010.201558. Epub ahead of print
-
Hester, R. L., Iliescu, R., Summers, R. L., and Coleman, T. G. (2010). Systems biology and integrative physiologi-cal modeling. J. Physiol. doi: 10.1113/ jphysiol.2010.201558. [Epub ahead of print].
-
(2010)
J. Physiol.
-
-
Hester, R.L.1
Iliescu, R.2
Summers, R.L.3
Coleman, T.G.4
-
22
-
-
0037342537
-
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
-
Hucka, M., Finney, A., Sauro, H. M., Bolouri, H., Doyle, J. C., Kitano, H., Arkin, A. P., Bornstein, B. J., Bray, D., Cornish-Bowden, A., Cuellar, A. A., Dronov, S., Gilles, E. D., Ginkel, M.,Gor, V., Goryanin, I. I., Hedley, W. J., Hodgman, T. C., Hofmeyr, J. H., Hunter, P. J., Juty, N. S., Kasberger, J. L., Kremling, A., Kummer, U., Le Novère, N., Loew, L. M., Lucio, D., Mendes, P., Minch, E., Mjolsness, E. D., Nakayama, Y., Nelson, M. R., Nielsen, P. F., Sakurada, T., Schaff, J. C., Shapiro, B. E., Shimizu, T. S., Spence, H. D., Stelling, J., Takahashi, K., Tomita, M., Wagner, J., and Wang, J. (2003). The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19, 524-531.
-
(2003)
Bioinformatics
, vol.19
, pp. 524-531
-
-
Hucka, M.1
Finney, A.2
Sauro, H.M.3
Bolouri, H.4
Doyle, J.C.5
Kitano, H.6
Arkin, A.P.7
Bornstein, B.J.8
Bray, D.9
Cornish-Bowden, A.10
Cuellar, A.A.11
Dronov, S.12
Gilles, E.D.13
Ginkel, M.14
Gor, V.15
Goryanin, I.I.16
Hedley, W.J.17
Hodgman, T.C.18
Hofmeyr, J.H.19
Hunter, P.J.20
Juty, N.S.21
Kasberger, J.L.22
Kremling, A.23
Kummer, U.24
Le Novère, N.25
Loew, L.M.26
Lucio, D.27
Mendes, P.28
Minch, E.29
Mjolsness, E.D.30
Nakayama, Y.31
Nelson, M.R.32
Nielsen, P.F.33
Sakurada, T.34
Schaff, J.C.35
Shapiro, B.E.36
Shimizu, T.S.37
Spence, H.D.38
Stelling, J.39
Takahashi, K.40
Tomita, M.41
Wagner, J.42
Wang, J.43
more..
-
24
-
-
33744547840
-
Pharmacogenetics and pharmacogenomics: origin, status, and the hope for personalized medi-cine
-
Kalow, W. (2006). Pharmacogenetics and pharmacogenomics: origin, status, and the hope for personalized medi-cine. Pharmacogenomics J. 6, 162-165.
-
(2006)
Pharmacogenomics J
, vol.6
, pp. 162-165
-
-
Kalow, W.1
-
25
-
-
17144418176
-
Physiologically-based pharmacoki-netic and toxicokinetic models in cancer risk assessment
-
Krishan, K., and Johanson, G. (2005). Physiologically-based pharmacoki-netic and toxicokinetic models in cancer risk assessment. J. Environ. Sci. Health 23, 31-53.
-
(2005)
J. Environ. Sci. Health
, vol.23
, pp. 31-53
-
-
Krishan, K.1
Johanson, G.2
-
26
-
-
77956411284
-
Towards whole-body systems physiology
-
Kuepfer, L. (2010). Towards whole-body systems physiology. Mol. Syst. Biol. 6, 409.
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 409
-
-
Kuepfer, L.1
-
27
-
-
41949099850
-
Development of good modelling practice for physi-ologically based pharmacokinetic models for use in risk assessment: the first steps
-
Loizou, G., Spendiff, M., Barton, H. A., Bessems, J., Bois, F. Y., d'Yvoire, M. B., Buist, H., Clewell, H. J. III, Meek, B., Gundert-Remy, U., Goerlitz, G., and Schmitt, W. (2008). Development of good modelling practice for physi-ologically based pharmacokinetic models for use in risk assessment: the first steps. Regul. Toxicol. Pharmacol. 50, 400-411.
-
(2008)
Regul. Toxicol. Pharmacol.
, vol.50
, pp. 400-411
-
-
Loizou, G.1
Spendiff, M.2
Barton, H.A.3
Bessems, J.4
Bois, F.Y.5
d'Yvoire, M.B.6
Buist, H.7
Clewell III, H.J.8
Meek, B.9
Gundert-Remy, U.10
Goerlitz, G.11
Schmitt, W.12
-
28
-
-
0028467454
-
Tumor growth in vivo and as multicellular spheroids compared by mathematical models
-
Marusic, M., Bajzer, Z., Vuk-Pavlovic, S., and Freyer, J. P. (1994). Tumor growth in vivo and as multicellular spheroids compared by mathematical models. Bull. Math. Biol. 56, 617-631.
-
(1994)
Bull. Math. Biol.
, vol.56
, pp. 617-631
-
-
Marusic, M.1
Bajzer, Z.2
Vuk-Pavlovic, S.3
Freyer, J.P.4
-
29
-
-
34447330544
-
Whole-body physi-ologically based pharmacokinetic models
-
Nestorov, I. (2007). Whole-body physi-ologically based pharmacokinetic models. Expert Opin. Drug Metab. Toxicol. 3, 235-249.
-
(2007)
Expert Opin. Drug Metab. Toxicol.
, vol.3
, pp. 235-249
-
-
Nestorov, I.1
-
30
-
-
0035044107
-
Prediction of adipose tissue: plasma partition coefficients for struc-turally unrelated drugs
-
Poulin, P., Schoenlein, K., and Theil, F. P. (2001). Prediction of adipose tissue: plasma partition coefficients for struc-turally unrelated drugs. J. Pharm. Sci. 90, 436-447.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 436-447
-
-
Poulin, P.1
Schoenlein, K.2
Theil, F.P.3
-
31
-
-
0036144815
-
Prediction of pharmacokinetics prior to in vivo studies 1. Mechanism-based prediction of volume of distribution
-
Poulin, P., and Theil, F. P. (2002a). Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution. J. Pharm. Sci. 91, 129-156.
-
(2002)
J. Pharm. Sci.
, vol.91
, pp. 129-156
-
-
Poulin, P.1
Theil, F.P.2
-
32
-
-
0036075799
-
Prediction of pharmacokinetics prior to in vivo studies II. Generic physi-ologically based pharmacokinetic models of drug disposition
-
Poulin, P., and Theil, F. P. (2002b). Prediction of pharmacokinetics prior to in vivo studies. II. Generic physi-ologically based pharmacokinetic models of drug disposition. J. Pharm. Sci. 91, 1358-1370.
-
(2002)
J. Pharm. Sci.
, vol.91
, pp. 1358-1370
-
-
Poulin, P.1
Theil, F.P.2
-
33
-
-
66749089871
-
Comparing the growth kinetics of cell populations in two and three dimen-sions
-
Radszuweit, M., Block, M., Hengstler, J. G., Scholl, E., and Drasdo, D. (2009).Comparing the growth kinetics of cell populations in two and three dimen-sions. Phys. Rev. E. Stat. Nonlin. Soft Matter Phys. 79(Pt 1),051907.
-
(2009)
Phys. Rev. E. Stat. Nonlin. Soft Matter Phys.
, vol.79
, Issue.PT 1
, pp. 051907
-
-
Radszuweit, M.1
Block, M.2
Hengstler, J.G.3
Scholl, E.4
Drasdo, D.5
-
34
-
-
67849116739
-
Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast can-cer patients
-
Rae, J. M., Sikora, M. J., Henry, N. L., Li, L., Kim, S., Oesterreich, S., Skaar, T. C., Nguyen, A. T., Desta, Z., Storniolo, A. M., Flockhart, D. A., Hayes, D. F., and Stearns, V. (2009). Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast can-cer patients. Pharmacogenomics J. 9, 258-264.
-
(2009)
Pharmacogenomics J
, vol.9
, pp. 258-264
-
-
Rae, J.M.1
Sikora, M.J.2
Henry, N.L.3
Li, L.4
Kim, S.5
Oesterreich, S.6
Skaar, T.C.7
Nguyen, A.T.8
Desta, Z.9
Storniolo, A.M.10
Flockhart, D.A.11
Hayes, D.F.12
Stearns, V.13
-
35
-
-
0037078982
-
Control, exploitation and tol-erance of intracellular noise
-
Rao, C. V., Wolf, D. M., and Arkin, A. P. (2002). Control, exploitation and tol-erance of intracellular noise. Nature 420, 231-237.
-
(2002)
Nature
, vol.420
, pp. 231-237
-
-
Rao, C.V.1
Wolf, D.M.2
Arkin, A.P.3
-
36
-
-
21344469211
-
Physiologically based phar-macokinetic modeling 1 predicting the tissue distribution of moderate-to-strong bases
-
Rodgers, T., Leahy, D., and Rowland, M. (2005a). Physiologically based phar-macokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J. Pharm. Sci. 94, 1259-1276.
-
(2005)
J. Pharm. Sci.
, vol.94
, pp. 1259-1276
-
-
Rodgers, T.1
Leahy, D.2
Rowland, M.3
-
37
-
-
21344463534
-
Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat
-
Rodgers, T., Leahy, D., and Rowland, M. (2005b). Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. J. Pharm. Sci. 94, 1237-1248.
-
(2005)
J. Pharm. Sci.
, vol.94
, pp. 1237-1248
-
-
Rodgers, T.1
Leahy, D.2
Rowland, M.3
-
38
-
-
33745055239
-
Physiologically based pharmacoki-netic modelling 2 predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions
-
Rodgers, T., and Rowland, M. (2006). Physiologically based pharmacoki-netic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J. Pharm. Sci. 95, 1238-1257.
-
(2006)
J. Pharm. Sci.
, vol.95
, pp. 1238-1257
-
-
Rodgers, T.1
Rowland, M.2
-
39
-
-
34247556082
-
Mechanistic approaches to volume of distribution predictions: under-standing the processes
-
Rodgers, T., and Rowland, M. (2007). Mechanistic approaches to volume of distribution predictions: under-standing the processes. Pharm. Res. 24, 918-933.
-
(2007)
Pharm. Res.
, vol.24
, pp. 918-933
-
-
Rodgers, T.1
Rowland, M.2
-
40
-
-
0027178664
-
SCAMP: a general-purpose simulator and metabolic con-trol analysis program
-
Sauro, H. M. (1993). SCAMP: a general-purpose simulator and metabolic con-trol analysis program. Comput. Appl. Biosci. 9, 441-450.
-
(1993)
Comput. Appl. Biosci.
, vol.9
, pp. 441-450
-
-
Sauro, H.M.1
-
41
-
-
38549150391
-
General approach for the calculation of tissue to plasma partition coefficients
-
Schmitt, W. (2008). General approach for the calculation of tissue to plasma partition coefficients. Toxicol. In Vitro 22, 457-467.
-
(2008)
Toxicol. In Vitro
, vol.22
, pp. 457-467
-
-
Schmitt, W.1
-
42
-
-
9544230707
-
Solving ODEs and DDEs with residual control
-
Shampine, L. F. (2005). Solving ODEs and DDEs with residual control. Appl. Num. Math. 52, 113-127.
-
(2005)
Appl. Num. Math.
, vol.52
, pp. 113-127
-
-
Shampine, L.F.1
-
43
-
-
33845257870
-
Variability and memory of protein levels in human cells
-
Sigal, A., Milo, R., Cohen, A., Geva-Zatorsky, N., Klein, Y., Liron, Y., Rosenfeld, N., Danon, T., Perzov, N., and Alon, U. (2006). Variability and memory of protein levels in human cells. Nature 444, 643-646.
-
(2006)
Nature
, vol.444
, pp. 643-646
-
-
Sigal, A.1
Milo, R.2
Cohen, A.3
Geva-Zatorsky, N.4
Klein, Y.5
Liron, Y.6
Rosenfeld, N.7
Danon, T.8
Perzov, N.9
Alon, U.10
-
44
-
-
33847031732
-
CYP2D6 worldwide genetic varia-tion shows high frequency of altered activity variants and no continental structure
-
Sistonen, J., Sajantila, A., Lao, O., Corander, J., Barbujani, G., and Fuselli, S. (2007). CYP2D6 worldwide genetic varia-tion shows high frequency of altered activity variants and no continental structure. Pharmacogenet. Genomics 17, 93-101.
-
(2007)
Pharmacogenet. Genomics
, vol.17
, pp. 93-101
-
-
Sistonen, J.1
Sajantila, A.2
Lao, O.3
Corander, J.4
Barbujani, G.5
Fuselli, S.6
-
45
-
-
0034926426
-
Global sensitivity indices for nonlinear mathemati-cal models and their Monte Carloestimates
-
Sobol', I. M. (2001). Global sensitivity indices for nonlinear mathemati-cal models and their Monte Carloestimates. Math. Comp. Simul. 55, 271-280.
-
(2001)
Math. Comp. Simul.
, vol.55
, pp. 271-280
-
-
Sobol', I.M.1
-
46
-
-
66249136447
-
Non-genetic origins of cell-to-cell variability in TRAIL-induced apop-tosis
-
Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M., and Sorger, P. K. (2009). Non-genetic origins of cell-to-cell variability in TRAIL-induced apop-tosis. Nature 459, 428-432.
-
(2009)
Nature
, vol.459
, pp. 428-432
-
-
Spencer, S.L.1
Gaudet, S.2
Albeck, J.G.3
Burke, J.M.4
Sorger, P.K.5
-
47
-
-
35348988164
-
Network analysis of oncogenic Ras activation in cancer
-
Stites, E. C., Trampont, P. C., Ma, Z., and Ravichandran, K. S. (2007). Network analysis of oncogenic Ras activation in cancer. Science 318, 463-467.
-
(2007)
Science
, vol.318
, pp. 463-467
-
-
Stites, E.C.1
Trampont, P.C.2
Ma, Z.3
Ravichandran, K.S.4
-
48
-
-
38449087461
-
The clini-cal role of genetic polymorphisms in drug-metabolizing enzymes
-
Tomalik-Scharte, D., Lazar, A., Fuhr, U., and Kirchheiner, J. (2008). The clini-cal role of genetic polymorphisms in drug-metabolizing enzymes. Pharmacogenomics J. 8, 4-15.
-
(2008)
Pharmacogenomics J
, vol.8
, pp. 4-15
-
-
Tomalik-Scharte, D.1
Lazar, A.2
Fuhr, U.3
Kirchheiner, J.4
-
49
-
-
4143068042
-
Non-linear mixed-effects pharmacok-inetic/pharmacodynamic modelling in NLME using differential equations
-
Tornoe, C. W., Agerso, H., Jonsson, E. N., Madsen, H., and Nielsen, H. A. (2004). Non-linear mixed-effects pharmacok-inetic/pharmacodynamic modelling in NLME using differential equations. Comput. Methods Programs Biomed. 76, 31-40.
-
(2004)
Comput. Methods Programs Biomed.
, vol.76
, pp. 31-40
-
-
Tornoe, C.W.1
Agerso, H.2
Jonsson, E.N.3
Madsen, H.4
Nielsen, H.A.5
-
50
-
-
34247394165
-
Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body phys-iologically-based pharmacokinetic (WB-PBPK) models
-
Vossen, M., Sevestre, M., Niederalt, C., Jang, I. J., Willmann, S., and Edginton, A. N. (2007). Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body phys-iologically-based pharmacokinetic (WB-PBPK) models. Theor. Biol. Med. Model. 4, 13.
-
(2007)
Theor. Biol. Med. Model.
, vol.4
, pp. 13
-
-
Vossen, M.1
Sevestre, M.2
Niederalt, C.3
Jang, I.J.4
Willmann, S.5
Edginton, A.N.6
-
51
-
-
34250004062
-
Development and validation of a physiology-based model for the prediction of oral absorption in monkeys
-
Willmann, S., Edginton, A. N., and Dressman, J. B. (2007a). Development and validation of a physiology-based model for the prediction of oral absorption in monkeys. Pharm. Res. 24, 1275-1282.
-
(2007)
Pharm. Res.
, vol.24
, pp. 1275-1282
-
-
Willmann, S.1
Edginton, A.N.2
Dressman, J.B.3
-
52
-
-
34249905607
-
Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs
-
Willmann, S., Hohn, K., Edginton, A., Sevestre, M., Solodenko, J., Weiss, W., Lippert, J., and Schmitt, W. (2007b). Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs. J. Pharmacokinet. Pharmacodyn. 34, 401-431.
-
(2007)
J. Pharmacokinet. Pharmacodyn.
, vol.34
, pp. 401-431
-
-
Willmann, S.1
Hohn, K.2
Edginton, A.3
Sevestre, M.4
Solodenko, J.5
Weiss, W.6
Lippert, J.7
Schmitt, W.8
-
53
-
-
85047682052
-
Whole-body physiologically based pharma-cokinetic population modelling of oral drug administration: inter-individual variability of cimetidine absorption
-
Willmann, S., Edginton, A. N., Kleine-Besten, M., Jantratid, E., Thelen, K., and Dressman, J. B. (2009a). Whole-body physiologically based pharma-cokinetic population modelling of oral drug administration: inter-individual variability of cimetidine absorption. J. Pharm. Pharmacol. 61, 891-899.
-
(2009)
J. Pharm. Pharmacol.
, vol.61
, pp. 891-899
-
-
Willmann, S.1
Edginton, A.N.2
Kleine-Besten, M.3
Jantratid, E.4
Thelen, K.5
Dressman, J.B.6
-
54
-
-
70450240777
-
Risk of codeine treatment dur-ing breastfeeding - a quantitative mechanistic modeling study
-
Willmann, S., Edginton, A. N., Coboeken, K., Ahr, G., and Lippert, J. (2009b). Risk of codeine treatment dur-ing breastfeeding - a quantitative mechanistic modeling study. Clin. Pharmacol. Ther. 86, 634-643.
-
(2009)
Clin. Pharmacol. Ther.
, vol.86
, pp. 634-643
-
-
Willmann, S.1
Edginton, A.N.2
Coboeken, K.3
Ahr, G.4
Lippert, J.5
-
55
-
-
33748338819
-
From physicochemistry to absorption and distribution: predic-tive mechanistic modelling and com-putational tools
-
Willmann, S., Lippert, J., and Schmitt, W. (2005). From physicochemistry to absorption and distribution: predic-tive mechanistic modelling and com-putational tools. Expert Opin. Drug Metab. Toxicol. 1, 159-168.
-
(2005)
Expert Opin. Drug Metab. Toxicol.
, vol.1
, pp. 159-168
-
-
Willmann, S.1
Lippert, J.2
Schmitt, W.3
-
57
-
-
0344084044
-
A physiologic model for simulat-ing gastrointestinal flow and drug absorption in rats
-
Willmann, S., Schmitt, W., Keldenich, J., and Dressman, J. B. (2003b). A physiologic model for simulat-ing gastrointestinal flow and drug absorption in rats. Pharm. Res. 20, 1766-1771.
-
(2003)
Pharm. Res.
, vol.20
, pp. 1766-1771
-
-
Willmann, S.1
Schmitt, W.2
Keldenich, J.3
Dressman, J.B.4
-
58
-
-
3242778534
-
A physiological model for the estimation of the fraction dose absorbed in humans
-
Willmann, S., Schmitt, W., Keldenich, J., Lippert, J., and Dressman, J. B. (2004). A physiological model for the estimation of the fraction dose absorbed in humans. J. Med. Chem. 47, 4022-4031.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 4022-4031
-
-
Willmann, S.1
Schmitt, W.2
Keldenich, J.3
Lippert, J.4
Dressman, J.B.5
-
59
-
-
0034790063
-
Comprehensive analysis of the genetic factors determining expres-sion and function of hepatic CYP2D6
-
Zanger, U. M., Fischer, J., Raimundo, S., Stuven, T., Evert, B. O., Schwab, M., and Eichelbaum, M. (2001). Comprehensive analysis of the genetic factors determining expres-sion and function of hepatic CYP2D6. Pharmacogenetics 11, 573-585.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 573-585
-
-
Zanger, U.M.1
Fischer, J.2
Raimundo, S.3
Stuven, T.4
Evert, B.O.5
Schwab, M.6
Eichelbaum, M.7
-
60
-
-
51249086247
-
SBML-SAT: a sys-tems biology markup language (SBML) based sensitivity analysis tool
-
doi: 10.1186/1471-2105-9-342
-
Zi, Z., Zheng, Y., Rundell, A. E., and Klipp, E. (2008). SBML-SAT: a sys-tems biology markup language (SBML) based sensitivity analysis tool. BMC Bioinformatics 9, 342. doi: 10.1186/1471-2105-9-342
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 342
-
-
Zi, Z.1
Zheng, Y.2
Rundell, A.E.3
Klipp, E.4
|