Analysis of gene-environment interactions by "stressing-the-genotype" studies: The angiotensin converting enzyme and exercise-induced left ventricular hypertrophy as an example

Italian Heart Journal

Volumn 3, Issue 1, 2002, Pages 10-14

  Montgomery, Hugh ^a   Brull, David ^a   Humphries, Steve E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Angiotensin converting enzyme; Exercise; Gene environment interaction; Left ventricular hypertrophy

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; LOSARTAN;

ACCURACY; ALLELE; ARMY; ARTICLE; BASE PAIRING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ENVIRONMENTAL FACTOR; EXERCISE; GENE DELETION; GENE INSERTION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC SCREENING; HEART FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HOMOZYGOSITY; HUMAN; HYPERTENSION; INTRON; LEAN BODY WEIGHT; MALE; MULTIFACTORIAL GENETIC DISORDER; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RANDOMIZED CONTROLLED TRIAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRAINING;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CORONARY ARTERIOSCLEROSIS; ENVIRONMENTAL EXPOSURE; EXERCISE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MALE; MOLECULAR BIOLOGY; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC;

EID: 0036204119     PISSN: 1129471X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: The Framingham study
2. Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change
3. Genes, variation of cholesterol and fat intake and serum lipids
4. Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: Studies in the fasting and post-prandial states. The Research Studies
5. Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides
6. ApoCIII gene variants modulate postprandial response to both glucose and fat tolerance tests
7. The acute rise in serum fibrinogen concentration with exercise is influenced by the G-453-A polymorphism of the beta-fibrinogen gene
8. Positive association of the fibrinogen H1/H2 gene variation to basal fibrinogen levels and to the increase in fibrinogen concentration during acute phase reaction but not to coronary artery disease and myocardial infarction
9. Impact of the -455G>A promoter polymorphism in the β-fibrinogen gene on stimulated fibrinogen production following bypass surgery
10. Dietary fat intake and plasma factor VII antigen concentration
11. Correlation of factor VIIa values with factor VII gene polymorphism, fasting and postprandial triglyceride levels, and subclinical carotid atherosclerosis
12. Dietary effects on coagulation factor VII vary across genotypes of the R/Q353 polymorphism in elderly people
13. Dietary oleic and palmitic acids and postprandial factor VII in middle-aged men heterozygous and homozygous for factor VII R353Q polymorphism
14. Interleukin-6 gene -174G>C and -572G>C promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery
15. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
16. The 677C→T mutation in the methylenetetrahydrofolate reductase gene: Associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease
17. Fasting, postprandial, and post-methionine-load homocysteinaemia and methylenetetrahydrofolate reductase polymorphism in vascular disease
18. Variability of fasting and post-methionine plasma homocysteine levels in normo- and hyperhomocysteinaemic individuals
19. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training
20. Left ventricular hypertrophy with exercise and the angiotensin converting enzyme gene I/D polymorphism: A randomized controlled trial with losartan
21. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels
22. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism
23. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
24. A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction
25. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls
26. Inhibiting tissue angiotensin-converting enzyme. A pound of flesh without the blood?
27. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
28. Circulating vs local renin-angiotensin system in cardiovascular homeostasis
29. Expression of angiotensin converting enzyme and chymase in human atria
30. ACE insertion/deletion genotype affects bradykinin metabolism
31. Reduction of infarct size by local angiotensin-converting enzyme inhibition is abolished by a bradykinin antagonist
32. Prediction of coronary heart disease using risk factor categories