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Volumn 12, Issue 1, 2009, Pages 1-24

Database for physiologically based pharmacokinetic (PBPK) modeling: Physiological data for healthy and health-impaired elderly

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE BLOOD FLOW; AGING; BLOOD COMPONENT; BODY COMPOSITION; BODY MASS; BODY WEIGHT; BRAIN BLOOD FLOW; BRAIN WEIGHT; BREATHING RATE; CHRONIC OBSTRUCTIVE LUNG DISEASE; DIABETES MELLITUS; ELDERLY CARE; ETHNICITY; GENETIC POLYMORPHISM; GLOMERULUS FILTRATION RATE; HEALTH HAZARD; HEART DISEASE; HEART INDEX; HEART OUTPUT; HEART WEIGHT; HUMAN; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY DISEASE; KIDNEY MASS; LIVER BLOOD FLOW; LIVER DISEASE; LIVER WEIGHT; LUNG FUNCTION; LUNG HEMODYNAMICS; LUNG VENTILATION; LUNG WEIGHT; METABOLIC CLEARANCE RATE; MUSCLE BLOOD FLOW; OBESITY; ORGAN SIZE; REVIEW; RISK ASSESSMENT; SEX DIFFERENCE; SKIN BLOOD FLOW; SPLANCHNIC BLOOD FLOW; SPLEEN WEIGHT; TISSUE BLOOD FLOW;

EID: 58149142515     PISSN: 10937404     EISSN: 15216950     Source Type: Journal    
DOI: 10.1080/10937400802545060     Document Type: Review
Times cited : (79)

References (121)
  • 2
    • 0004657711 scopus 로고
    • Blood flow in the foot and calf in the elderly; A comparison with that in young adults
    • Allwood, M. J. 1958. Blood flow in the foot and calf in the elderly; A comparison with that in young adults. Clin. Sci. (Lond.) 17:331-338.
    • (1958) Clin. Sci. (Lond.) , vol.17 , pp. 331-338
    • Allwood, M.J.1
  • 3
    • 0014555315 scopus 로고
    • Muscle blood flow in normal and hypertensive subjects: Influence of age, exercise, and body position
    • Amery, A., Bossaert, H., Verstraete, M., and Belgium, L. 1969. Muscle blood flow in normal and hypertensive subjects: Influence of age, exercise, and body position. Am. Heart J. 78:211-216.
    • (1969) Am. Heart J , vol.78 , pp. 211-216
    • Amery, A.1    Bossaert, H.2    Verstraete, M.3    Belgium, L.4
  • 4
    • 0027962628 scopus 로고
    • Effects of smoking intervention and the use of an inhaled anticholineergic bronchodilator on the rate of decline of FEV1
    • Anthonisen, N. R., Connett, J. E., and Kiley, J. P. 1994. Effects of smoking intervention and the use of an inhaled anticholineergic bronchodilator on the rate of decline of FEV1. J. Am. Med. Assoc. 272:1497-1505.
    • (1994) J. Am. Med. Assoc , vol.272 , pp. 1497-1505
    • Anthonisen, N.R.1    Connett, J.E.2    Kiley, J.P.3
  • 5
    • 0019847451 scopus 로고
    • Disposition of antipyrine and phenytoin correlated with age and liver volume in man
    • Bach, B., Hansen, J. M., Kampmann, J. P., Rasmussen, S. N., and Skovsted, L. 1981. Disposition of antipyrine and phenytoin correlated with age and liver volume in man. Clin. Pharmacokinet. 6:389-396.
    • (1981) Clin. Pharmacokinet , vol.6 , pp. 389-396
    • Bach, B.1    Hansen, J.M.2    Kampmann, J.P.3    Rasmussen, S.N.4    Skovsted, L.5
  • 9
    • 0014371826 scopus 로고
    • Left ventricular end-diastolic pressure and cardiac output at rest and during exercise in patients with angina pectoris
    • Benchimol, A., Maroko, P. R., Pedraza, A., Brener, L., and Buxbaum, A. 1968. Left ventricular end-diastolic pressure and cardiac output at rest and during exercise in patients with angina pectoris. Cardiology 53:261-279.
    • (1968) Cardiology , vol.53 , pp. 261-279
    • Benchimol, A.1    Maroko, P.R.2    Pedraza, A.3    Brener, L.4    Buxbaum, A.5
  • 10
    • 0000261394 scopus 로고
    • The effect of increasing age on the distribution of peripheral blood flow in man
    • Bender, A. D. 1965. The effect of increasing age on the distribution of peripheral blood flow in man. J. Am. Geriatr. Soc. 13:192-198.
    • (1965) J. Am. Geriatr. Soc , vol.13 , pp. 192-198
    • Bender, A.D.1
  • 11
    • 0034033851 scopus 로고    scopus 로고
    • Human cytochrome P450 maximal activities in pediatric versus adult liver
    • Blanco, J. G., Harrison, P. L., Evans, W. E., and Relling, M. V. 2000. Human cytochrome P450 maximal activities in pediatric versus adult liver. Drug Metab. Dispos. 28:379-382.
    • (2000) Drug Metab. Dispos , vol.28 , pp. 379-382
    • Blanco, J.G.1    Harrison, P.L.2    Evans, W.E.3    Relling, M.V.4
  • 12
    • 0032956432 scopus 로고    scopus 로고
    • Pharmacokinetic considerations in obesity
    • Blouin, R. A., and Warren, G. W. 1999. Pharmacokinetic considerations in obesity. J. Pharm. Sci. 88:1-7.
    • (1999) J. Pharm. Sci , vol.88 , pp. 1-7
    • Blouin, R.A.1    Warren, G.W.2
  • 13
    • 0006323121 scopus 로고
    • Simultaneous measurement of effective renal blood flow and cardiac output in resting normal subjects and patients with essential hypertension
    • Bolomey, A. A., Michie, A. J., Michie, C., Breed, E. S., Schreiner, G. E., and Lauson, H. D. 1948. Simultaneous measurement of effective renal blood flow and cardiac output in resting normal subjects and patients with essential hypertension. J. Clin. Invest. 28:10-17.
    • (1948) J. Clin. Invest , vol.28 , pp. 10-17
    • Bolomey, A.A.1    Michie, A.J.2    Michie, C.3    Breed, E.S.4    Schreiner, G.E.5    Lauson, H.D.6
  • 14
    • 0013563584 scopus 로고
    • Normal variability in weight of the adult human liver and spleen
    • Boyd, E. 1933. Normal variability in weight of the adult human liver and spleen. Arch. Pathol. 16:350-372.
    • (1933) Arch. Pathol , vol.16 , pp. 350-372
    • Boyd, E.1
  • 17
    • 25844524877 scopus 로고    scopus 로고
    • Neurodegenerative diseases: An overview of environmental risk factors
    • Brown, R. P., Lockwood, A. H., and Sonawane, B. R. 2005. Neurodegenerative diseases: An overview of environmental risk factors. Environ. Health Perspect. 113:1250-1256.
    • (2005) Environ. Health Perspect , vol.113 , pp. 1250-1256
    • Brown, R.P.1    Lockwood, A.H.2    Sonawane, B.R.3
  • 22
    • 11344264355 scopus 로고    scopus 로고
    • Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment
    • Clark, L. H., Setzer, R. W., and Barton, H. A. 2004. Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment. Risk Anal. 24:1697-1717.
    • (2004) Risk Anal , vol.24 , pp. 1697-1717
    • Clark, L.H.1    Setzer, R.W.2    Barton, H.A.3
  • 25
    • 0025138539 scopus 로고
    • Hemodynamic and metabolic correlates in adipose tissue: Pathophysiologic considerations
    • Crandall, D. L., and DiGirolamo, M. 1990. Hemodynamic and metabolic correlates in adipose tissue: pathophysiologic considerations. FASEB J. 4:141-147.
    • (1990) FASEB J , vol.4 , pp. 141-147
    • Crandall, D.L.1    DiGirolamo, M.2
  • 27
    • 0022610214 scopus 로고
    • The fractional distribution of the cardiac output in man using microspheres labelled with technetium 99m
    • Crean, P. A., Pratt, T., Davies, G. J., Myers, M., Lavender, P., and Maseri, A. 1986. The fractional distribution of the cardiac output in man using microspheres labelled with technetium 99m. Br. J. Radiol. 59:209-215.
    • (1986) Br. J. Radiol , vol.59 , pp. 209-215
    • Crean, P.A.1    Pratt, T.2    Davies, G.J.3    Myers, M.4    Lavender, P.5    Maseri, A.6
  • 28
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies, B., and Morris, T. 1993. Physiological parameters in laboratory animals and humans. Pharm. Res. 10:1093-1095.
    • (1993) Pharm. Res , vol.10 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 29
    • 76549236600 scopus 로고
    • Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males
    • Davies, D., and Shock, N. 1950. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J. Clin. Invest. 29:496-507.
    • (1950) J. Clin. Invest , vol.29 , pp. 496-507
    • Davies, D.1    Shock, N.2
  • 30
    • 0015277010 scopus 로고
    • Portal circulation in humans studied by a dye-dilution technique
    • Dencker, H., Gothlin, J., Olin, T., and Tibblin, S. 1972. Portal circulation in humans studied by a dye-dilution technique. Eur. Surg. Res. 4:81-89.
    • (1972) Eur. Surg. Res , vol.4 , pp. 81-89
    • Dencker, H.1    Gothlin, J.2    Olin, T.3    Tibblin, S.4
  • 31
    • 0035281809 scopus 로고    scopus 로고
    • Age-related decreases in basal limb blood flow in humans: Time course, determinants and habitual exercise effects
    • Dinenno, F. A., Seals, D. R., DeSouza, C. A., and Tanaka, H. 2001. Age-related decreases in basal limb blood flow in humans: Time course, determinants and habitual exercise effects. J. Physiol. 531:573-579.
    • (2001) J. Physiol , vol.531 , pp. 573-579
    • Dinenno, F.A.1    Seals, D.R.2    DeSouza, C.A.3    Tanaka, H.4
  • 32
    • 0025847748 scopus 로고
    • Body mass index as a measure of body fatness: Age and sex specific prediction formulas
    • Duerenberg, P., Weststrate, J. A., and Siedell, J. C. 1991. Body mass index as a measure of body fatness: Age and sex specific prediction formulas. Br. J. Nutr. 65:105-114.
    • (1991) Br. J. Nutr , vol.65 , pp. 105-114
    • Duerenberg, P.1    Weststrate, J.A.2    Siedell, J.C.3
  • 33
    • 0029134842 scopus 로고
    • Peripheral blood flow in the elderly during inhalational anaesthesia
    • Dwyer, R., and Howe, J. 1995. Peripheral blood flow in the elderly during inhalational anaesthesia. Acta Anaesthesiol. Scand. 39:939-944.
    • (1995) Acta Anaesthesiol. Scand , vol.39 , pp. 939-944
    • Dwyer, R.1    Howe, J.2
  • 34
    • 0017711201 scopus 로고
    • Hepatic drug acetylation and oxidation: Effects of aging in man
    • Farah, F., Taylor, W., Rawlins, M. D., and James, O. 1977. Hepatic drug acetylation and oxidation: Effects of aging in man. Br. Med. J. 2:155-156.
    • (1977) Br. Med. J , vol.2 , pp. 155-156
    • Farah, F.1    Taylor, W.2    Rawlins, M.D.3    James, O.4
  • 35
    • 72949146236 scopus 로고    scopus 로고
    • Fazekas, J., Thomas, A., Johnson, J., and Young, W. 1960. Effect of arterenol (norepinephrine) and epinephrine in cerebral hemodynamics and metabolism. AMA Arch. Neurol. 2:435-438.
    • Fazekas, J., Thomas, A., Johnson, J., and Young, W. 1960. Effect of arterenol (norepinephrine) and epinephrine in cerebral hemodynamics and metabolism. AMA Arch. Neurol. 2:435-438.
  • 36
    • 3743133426 scopus 로고
    • Cerebral hemodynamics and metabolism in subjects over 90 years of age
    • Fazekas, J., Kleh, J., and Witkin, L. 1953. Cerebral hemodynamics and metabolism in subjects over 90 years of age. J. Am. Geriatr. Soc. 1:836-839.
    • (1953) J. Am. Geriatr. Soc , vol.1 , pp. 836-839
    • Fazekas, J.1    Kleh, J.2    Witkin, L.3
  • 37
  • 39
    • 0021907243 scopus 로고
    • Body composition in elderly people. I. Determination of body composition by multiisotope method and the elimination kinetics of these isotopes in healthy elderly subjects
    • Fulop, T., Worum, I., Csongor, J., Foris, G., and Leovey, A. 1985. Body composition in elderly people. I. Determination of body composition by multiisotope method and the elimination kinetics of these isotopes in healthy elderly subjects. Gerontology 17:6-14.
    • (1985) Gerontology , vol.17 , pp. 6-14
    • Fulop, T.1    Worum, I.2    Csongor, J.3    Foris, G.4    Leovey, A.5
  • 40
    • 25844439617 scopus 로고    scopus 로고
    • Aging and the environment: A research framework
    • Geller, A. M., and Zenick, H. 2005. Aging and the environment: A research framework. Environ. Health Perspect. 113:1257-1262.
    • (2005) Environ. Health Perspect , vol.113 , pp. 1257-1262
    • Geller, A.M.1    Zenick, H.2
  • 41
    • 34047168679 scopus 로고    scopus 로고
    • Data for physiologically based pharmacokinetic modeling in neonatal animals: Physiological parameters in mice and Sprague-Dawley rats
    • Gentry, P. R., Haber, L. T., McDonald, T. B., Zhao, Q., Covington, T., Nance, P., Clewell, J. J. III., and Lipscomb, J. C. 2004. Data for physiologically based pharmacokinetic modeling in neonatal animals: Physiological parameters in mice and Sprague-Dawley rats. J. Child. Health 2:363-411.
    • (2004) J. Child. Health , vol.2 , pp. 363-411
    • Gentry, P.R.1    Haber, L.T.2    McDonald, T.B.3    Zhao, Q.4    Covington, T.5    Nance, P.6    Clewell III, J.J.7    Lipscomb, J.C.8
  • 42
    • 25844458497 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic factors that can affect sensitivity to neurotoxic sequelae in the elderly
    • Ginsberg, G., Hattis, D., Russ, A., and Sonawane, B. 2005. Pharmacokinetic and pharmacodynamic factors that can affect sensitivity to neurotoxic sequelae in the elderly. Environ. Health Perspect. 113:1243-1249.
    • (2005) Environ. Health Perspect , vol.113 , pp. 1243-1249
    • Ginsberg, G.1    Hattis, D.2    Russ, A.3    Sonawane, B.4
  • 43
    • 84965055013 scopus 로고
    • Respiratory function tests: Normal values of median altitudes and the prediction of normal results
    • Goldman, H. I., and Becklake, M. R. 1959. Respiratory function tests: Normal values of median altitudes and the prediction of normal results. Am. Rev. Tuberc. 79:457-467.
    • (1959) Am. Rev. Tuberc , vol.79 , pp. 457-467
    • Goldman, H.I.1    Becklake, M.R.2
  • 44
    • 0345623196 scopus 로고
    • II. Hormones and metabolism. Influence of steroids on cerebral metabolism in man
    • Gordan, G. S. 1956. II. Hormones and metabolism. Influence of steroids on cerebral metabolism in man. Recent Prog. Horm. Res. 12:153-174.
    • (1956) Recent Prog. Horm. Res , vol.12 , pp. 153-174
    • Gordan, G.S.1
  • 45
    • 0018415172 scopus 로고
    • Reduced serum albumin concentration in the elderly: A report from the Boston Collaborative Drug Surveillance Program
    • Greenblatt, D. J. 1979. Reduced serum albumin concentration in the elderly: A report from the Boston Collaborative Drug Surveillance Program. J. Am. Geriatr. Soc. 27:20-22
    • (1979) J. Am. Geriatr. Soc , vol.27 , pp. 20-22
    • Greenblatt, D.J.1
  • 47
    • 0344797022 scopus 로고
    • Changes in forearm blood flow with age
    • Hellon, R. F, and Clarke, R. S. J. 1959. Changes in forearm blood flow with age. Clin. Sci. 18:1-7.
    • (1959) Clin. Sci , vol.18 , pp. 1-7
    • Hellon, R.F.1    Clarke, R.S.J.2
  • 48
    • 0030901528 scopus 로고    scopus 로고
    • Age, fitness, and regional blood flow during exercise in the heat
    • Ho, C. W., Beard, J. L., Farrell, P. A., Minson, C. T., and Kenney, W. L. 1997. Age, fitness, and regional blood flow during exercise in the heat. J. Appl. Physiol 82:1126-1135.
    • (1997) J. Appl. Physiol , vol.82 , pp. 1126-1135
    • Ho, C.W.1    Beard, J.L.2    Farrell, P.A.3    Minson, C.T.4    Kenney, W.L.5
  • 50
    • 0025180992 scopus 로고
    • Effect of normal aging on the activity of human hepatic cytochrome P450IIE1
    • Hunt, C. M., Strater, S., and Stave, G. M. 1990. Effect of normal aging on the activity of human hepatic cytochrome P450IIE1. Biochem. Pharmacol. 40:1666-1669.
    • (1990) Biochem. Pharmacol , vol.40 , pp. 1666-1669
    • Hunt, C.M.1    Strater, S.2    Stave, G.M.3
  • 51
    • 0003444170 scopus 로고
    • ICRP, Man. Publication 23. Oxford: Pergamon Press
    • ICRP. 1975. Report of the Task Group on Reference Man. Publication 23. Oxford: Pergamon Press.
    • (1975) Report of the Task Group on Reference
  • 52
    • 0023299292 scopus 로고
    • Statistical analysis of the organ weights in 1,000 autopsy cases of Japanese aged over 60 years
    • Inoue, T., and Otsu, S. 1987. Statistical analysis of the organ weights in 1,000 autopsy cases of Japanese aged over 60 years. Acta Pathol. Jpn. 37:343-359.
    • (1987) Acta Pathol. Jpn , vol.37 , pp. 343-359
    • Inoue, T.1    Otsu, S.2
  • 55
    • 0014114704 scopus 로고
    • Influence of age on the hemodynamic response to exercise
    • Julius, S., Amery, A., Whitlock, L., and Conway, J. 1967. Influence of age on the hemodynamic response to exercise. Circulation 36:222-230.
    • (1967) Circulation , vol.36 , pp. 222-230
    • Julius, S.1    Amery, A.2    Whitlock, L.3    Conway, J.4
  • 56
    • 3543116721 scopus 로고    scopus 로고
    • Basal cerebral blood flow is dependent on the nitric oxide pathway in elderly but not in young healthy men
    • Kamper, A. M., Spilt, A., de Craen, A. J., van Buchem, M. A., Westendorp, R. G., and Blauw, G. J. 2004. Basal cerebral blood flow is dependent on the nitric oxide pathway in elderly but not in young healthy men. Exp. Gerontol. 39:1245-1248.
    • (2004) Exp. Gerontol , vol.39 , pp. 1245-1248
    • Kamper, A.M.1    Spilt, A.2    de Craen, A.J.3    van Buchem, M.A.4    Westendorp, R.G.5    Blauw, G.J.6
  • 57
    • 0018648882 scopus 로고
    • Normal cardiac output in relation to age and body size
    • Katori, R. 1979. Normal cardiac output in relation to age and body size. Tohoku J. Exp. Med. 128:377-387.
    • (1979) Tohoku J. Exp. Med , vol.128 , pp. 377-387
    • Katori, R.1
  • 58
    • 0028672471 scopus 로고
    • Effect of age on renal blood flow during exercise
    • Kenney, W. L., and Zappe, D. H. 1994. Effect of age on renal blood flow during exercise. Aging (Milano) 6:293-302.
    • (1994) Aging (Milano) , vol.6 , pp. 293-302
    • Kenney, W.L.1    Zappe, D.H.2
  • 59
    • 0028856346 scopus 로고
    • Age alters regional distribution of blood flow during moderate-intensity exercise
    • Kenney, W. L., and Ho, C. W. 1995. Age alters regional distribution of blood flow during moderate-intensity exercise. J. Appl. Physiol. 79:1112-1119.
    • (1995) J. Appl. Physiol , vol.79 , pp. 1112-1119
    • Kenney, W.L.1    Ho, C.W.2
  • 61
    • 9644289359 scopus 로고    scopus 로고
    • Reduced glomerular filtration rate in asymptomatic diabetic patients: Predictor of increased risk for cardiac events independent of albuminuria
    • Knobler, H., Zornitzki, T., Vered, S., Oettinger, M., Levy, R., Caspi, A., Faraggi, D., and Livschitz, S. 2004. Reduced glomerular filtration rate in asymptomatic diabetic patients: Predictor of increased risk for cardiac events independent of albuminuria. J. Am. Coll. Cardiol. 44:2142-2148.
    • (2004) J. Am. Coll. Cardiol , vol.44 , pp. 2142-2148
    • Knobler, H.1    Zornitzki, T.2    Vered, S.3    Oettinger, M.4    Levy, R.5    Caspi, A.6    Faraggi, D.7    Livschitz, S.8
  • 62
    • 58149160703 scopus 로고    scopus 로고
    • Knudson, R. J. 1991. Physiology of the aging lung. In The lung, Scientific foundations, ed. R. G.Crystal, pp. 1749-1759. New York: Raven Press.
    • Knudson, R. J. 1991. Physiology of the aging lung. In The lung, Scientific foundations, ed. R. G.Crystal, pp. 1749-1759. New York: Raven Press.
  • 63
    • 0025311070 scopus 로고
    • Changes in cardiovascular function with aging
    • Lakatta, E. G. 1990. Changes in cardiovascular function with aging. Eur. Heart J. 11(Suppl. C):22-29.
    • (1990) Eur. Heart J , vol.11 , Issue.SUPPL. C , pp. 22-29
    • Lakatta, E.G.1
  • 64
    • 49749217238 scopus 로고
    • Measurements of blood-flow through skeletal muscle by intramuscular injection of xenon-133
    • Lassen, N., Lindbjerg, J., and Munck, O. 1964. Measurements of blood-flow through skeletal muscle by intramuscular injection of xenon-133. Lancet 15:686-689.
    • (1964) Lancet , vol.15 , pp. 686-689
    • Lassen, N.1    Lindbjerg, J.2    Munck, O.3
  • 66
    • 0014149083 scopus 로고
    • Measurement of adipose tissue blood flow and perfusion in man by uptake of Kr1
    • Lesser, G. T., and Deutsch, S. 1967. Measurement of adipose tissue blood flow and perfusion in man by uptake of Kr1. J. Appl. Physiol 23:621-630.
    • (1967) J. Appl. Physiol , vol.23 , pp. 621-630
    • Lesser, G.T.1    Deutsch, S.2
  • 67
    • 0013940868 scopus 로고
    • Influence of age, renal disease, hypertension, diuretics, and calcium on the antidiuretic responses to suboptimal infusions of vasopressin
    • Lindeman, R. D., Lee, T. D., Yiengst, M. J., and Shock N. W. 1966. Influence of age, renal disease, hypertension, diuretics, and calcium on the antidiuretic responses to suboptimal infusions of vasopressin. J. Lab. Clin. Med. 68:206-223.
    • (1966) J. Lab. Clin. Med , vol.68 , pp. 206-223
    • Lindeman, R.D.1    Lee, T.D.2    Yiengst, M.J.3    Shock, N.W.4
  • 68
    • 0032437172 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation
    • Lucas, D., Farez, C., Bardou, L. G., Vaisse, J., Attali, J. R., and Valensi, P. 1998. Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation. Fundam. Clin. Pharmacol.12:553- 558.
    • (1998) Fundam. Clin. Pharmacol , vol.12 , pp. 553-558
    • Lucas, D.1    Farez, C.2    Bardou, L.G.3    Vaisse, J.4    Attali, J.R.5    Valensi, P.6
  • 69
    • 0018844558 scopus 로고
    • Changes of cardiac output caused by aging: An impedance cardiographic study
    • Luisada, A. A., Bhat, B. A., and Bioeng, V. K. 1980. Changes of cardiac output caused by aging: An impedance cardiographic study. Angiology 31:75-81.
    • (1980) Angiology , vol.31 , pp. 75-81
    • Luisada, A.A.1    Bhat, B.A.2    Bioeng, V.K.3
  • 70
    • 0021953937 scopus 로고
    • Determination of cardiac output at rest and during exercise by carbon dioxide rebreathing method in obstructive airway disease
    • Mahler, D. A., Matthay, R. A., Snyder, P. E., Neff, R. K., and Loke, J. 1985. Determination of cardiac output at rest and during exercise by carbon dioxide rebreathing method in obstructive airway disease. Am. Rev. Respir. Dis. 131:73-78.
    • (1985) Am. Rev. Respir. Dis , vol.131 , pp. 73-78
    • Mahler, D.A.1    Matthay, R.A.2    Snyder, P.E.3    Neff, R.K.4    Loke, J.5
  • 73
    • 0000969474 scopus 로고
    • Aging as a factor in the renal hemodynamic changes induced by a standardized pyrogen
    • McDonald, R. K., Solomon, D. H., and Shock, N. W. 1951. Aging as a factor in the renal hemodynamic changes induced by a standardized pyrogen. J. Clin. Invest. 30:457-462.
    • (1951) J. Clin. Invest , vol.30 , pp. 457-462
    • McDonald, R.K.1    Solomon, D.H.2    Shock, N.W.3
  • 74
    • 2642572647 scopus 로고    scopus 로고
    • Aging biology and geriatric clinical pharmacology
    • McLean, A. J., and Le Couteur, D. G. 2004. Aging biology and geriatric clinical pharmacology. Pharmacol. Rev. 56:163-184.
    • (2004) Pharmacol. Rev , vol.56 , pp. 163-184
    • McLean, A.J.1    Le Couteur, D.G.2
  • 76
    • 8244259016 scopus 로고
    • The renal extraction of p-aminohippurate in the aged individual
    • Miller, J. H., McDonald, R. K., and Shock, N. W. 1951. The renal extraction of p-aminohippurate in the aged individual. J. Gerontol. 3:213-216.
    • (1951) J. Gerontol , vol.3 , pp. 213-216
    • Miller, J.H.1    McDonald, R.K.2    Shock, N.W.3
  • 77
    • 0000341846 scopus 로고
    • Dead space ventilation in old age
    • Miller, R. M., and Tenney, S. M. 1956. Dead space ventilation in old age. J. Appl. Physiol. 9:321-327.
    • (1956) J. Appl. Physiol , vol.9 , pp. 321-327
    • Miller, R.M.1    Tenney, S.M.2
  • 79
    • 0029042972 scopus 로고
    • Relationship between respiratory muscle strength and lean body mass in men with COPD
    • Nishimura, Y., Tsutsumi, M., Nakata, H., Tsunenari, T., Maeda, H., and Yokoyama, M. 1995. Relationship between respiratory muscle strength and lean body mass in men with COPD. Chest 107:1232-1236.
    • (1995) Chest , vol.107 , pp. 1232-1236
    • Nishimura, Y.1    Tsutsumi, M.2    Nakata, H.3    Tsunenari, T.4    Maeda, H.5    Yokoyama, M.6
  • 80
    • 58149167499 scopus 로고
    • Changes in ventilation with age
    • eds. L. Cander and J. H. Moyer, pp, New York. Grune and Stratton
    • Norris, A. H., Mittman, C., and Shock, N. W. 1964. Changes in ventilation with age. In Aging of the lung perspectives, eds. L. Cander and J. H. Moyer, pp. 311-317. New York. Grune and Stratton.
    • (1964) Aging of the lung perspectives , pp. 311-317
    • Norris, A.H.1    Mittman, C.2    Shock, N.W.3
  • 81
    • 0029892172 scopus 로고    scopus 로고
    • Cardiac output in patients in their 90s]
    • Okazaki, K., Hirano, M., Suga, T., and Ohara, Y. 1996. [Cardiac output in patients in their 90s]. Masui 45:352-355.
    • (1996) Masui , vol.45 , pp. 352-355
    • Okazaki, K.1    Hirano, M.2    Suga, T.3    Ohara, Y.4
  • 83
    • 0028037221 scopus 로고
    • Effect of fasting and obesity in humans on the 6-hydroxylation of chlozoxazone: A putative probe of CYP2E1 activity
    • O'Shea, D. O., Davis, S. N., Kim, R. B., and Wilkinson, G. R. 1994. Effect of fasting and obesity in humans on the 6-hydroxylation of chlozoxazone: A putative probe of CYP2E1 activity. Clin. Pharmacol. Ther. 56:359-367.
    • (1994) Clin. Pharmacol. Ther , vol.56 , pp. 359-367
    • O'Shea, D.O.1    Davis, S.N.2    Kim, R.B.3    Wilkinson, G.R.4
  • 84
    • 0023897466 scopus 로고
    • Sulfotransferase in humans: Development and tissue distribution
    • Pacifici, G. M., Franchi, M., Colizzi, C., Giuliani, L., and Rane, A. 1988. Sulfotransferase in humans: Development and tissue distribution. Pharmacology 36:411-419.
    • (1988) Pharmacology , vol.36 , pp. 411-419
    • Pacifici, G.M.1    Franchi, M.2    Colizzi, C.3    Giuliani, L.4    Rane, A.5
  • 85
    • 4444278991 scopus 로고    scopus 로고
    • The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes
    • Parkinson, A., Mudra, D. R., Johnson, C., Dwyer, A., and Carroll, K. M. 2004. The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicol. Appl. Pharmacol. 199:193-209.
    • (2004) Toxicol. Appl. Pharmacol , vol.199 , pp. 193-209
    • Parkinson, A.1    Mudra, D.R.2    Johnson, C.3    Dwyer, A.4    Carroll, K.M.5
  • 86
    • 0342668213 scopus 로고
    • The elastic properties of the lungs in the aged
    • Pierce, J. A., and Ebert, R. V. 1958. The elastic properties of the lungs in the aged. J. Lab. Clin. Med. 51:63-71.
    • (1958) J. Lab. Clin. Med , vol.51 , pp. 63-71
    • Pierce, J.A.1    Ebert, R.V.2
  • 87
    • 0037436798 scopus 로고    scopus 로고
    • Physiological modeling of age-specific changes in the pharmacokinetics of organic chemicals in children
    • Price, K., Haddad, S., and Krishnan, K. 2003a Physiological modeling of age-specific changes in the pharmacokinetics of organic chemicals in children. J. Toxicol. Environ. Health A 66:417-433.
    • (2003) J. Toxicol. Environ. Health A , vol.66 , pp. 417-433
    • Price, K.1    Haddad, S.2    Krishnan, K.3
  • 89
    • 0036299414 scopus 로고    scopus 로고
    • Age-related decrease in energy expenditure at rest parallels reductions in mass of internal organs
    • Puggaard, L., Bjornsbo, K. S., Kock, K., Luders, K., Thobo-Carlsen, B., and Lammert, O. 2002. Age-related decrease in energy expenditure at rest parallels reductions in mass of internal organs. Am. J. Hum. Biol. 14:486-493.
    • (2002) Am. J. Hum. Biol , vol.14 , pp. 486-493
    • Puggaard, L.1    Bjornsbo, K.S.2    Kock, K.3    Luders, K.4    Thobo-Carlsen, B.5    Lammert, O.6
  • 90
    • 0002366805 scopus 로고
    • Brussels: C. Muquardt
    • Quetelet, L. A. 1869. Physique sociale, Vol. 2, p. 92. Brussels: C. Muquardt.
    • (1869) Physique sociale , vol.2 , pp. 92
    • Quetelet, L.A.1
  • 91
    • 0028305696 scopus 로고
    • Maximal skin blood flow is decreased in elderly men
    • Rooke, G. A., Savage, M. V., and Brengelmann, G. L. 1994. Maximal skin blood flow is decreased in elderly men. J. Appl. Physiol. 77:11-14.
    • (1994) J. Appl. Physiol , vol.77 , pp. 11-14
    • Rooke, G.A.1    Savage, M.V.2    Brengelmann, G.L.3
  • 92
  • 93
    • 0014904086 scopus 로고
    • Age changes in the human liver of the different races
    • Sato, T., Miwa, T., and Tauchi, H. 1970. Age changes in the human liver of the different races. Gerontologia 16:368-380.
    • (1970) Gerontologia , vol.16 , pp. 368-380
    • Sato, T.1    Miwa, T.2    Tauchi, H.3
  • 94
    • 58149169643 scopus 로고
    • Effects of aging on cerebral circulation and metabolism
    • Scheinberg, P., Blackburn, I., Rich, M., and Saslaw, M. 1950. Effects of aging on cerebral circulation and metabolism. Am. J. Med. 8:77-85.
    • (1950) Am. J. Med , vol.8 , pp. 77-85
    • Scheinberg, P.1    Blackburn, I.2    Rich, M.3    Saslaw, M.4
  • 96
    • 0025101204 scopus 로고
    • Glomerular volume in type 2 (noninsulin-dependent) diabetes estimated by a direct and unbiased stereologic method
    • Schmitz, A., Nyengaard, J. R., and Bendtsen, T. F. 1990. Glomerular volume in type 2 (noninsulin-dependent) diabetes estimated by a direct and unbiased stereologic method. Lab. Invest. 62:108-113.
    • (1990) Lab. Invest , vol.62 , pp. 108-113
    • Schmitz, A.1    Nyengaard, J.R.2    Bendtsen, T.F.3
  • 98
    • 0027292190 scopus 로고
    • Changes in plasma and hepatic lipids, small intestinal histology and pancreatic enzyme activity due to aging and dietary fiber in rats
    • Schneeman, B. O., and Richter, D. 1993. Changes in plasma and hepatic lipids, small intestinal histology and pancreatic enzyme activity due to aging and dietary fiber in rats. J. Nutr. 123:1328-1337.
    • (1993) J. Nutr , vol.123 , pp. 1328-1337
    • Schneeman, B.O.1    Richter, D.2
  • 99
    • 0023867058 scopus 로고
    • Relation of pressure and flow of pulmonary circulation in patients with chronic obstructive pulmonary disease
    • Seibold, H., Wieshammer, S., and Kress, P. 1988. Relation of pressure and flow of pulmonary circulation in patients with chronic obstructive pulmonary disease. Clin. Physiol Biochem. 6:29-35.
    • (1988) Clin. Physiol Biochem , vol.6 , pp. 29-35
    • Seibold, H.1    Wieshammer, S.2    Kress, P.3
  • 102
    • 0006985319 scopus 로고
    • Splanchnic blood flow in man by the bromsulfalein method: The relation of peripheral plasma bromsulfalein level to the calculated flow
    • Sherlock, S., Bearn, A. G., Billing, B. H., and Paterson, J. C. 1950. Splanchnic blood flow in man by the bromsulfalein method: The relation of peripheral plasma bromsulfalein level to the calculated flow. J. Lab. Clin. Med. 35:923-932.
    • (1950) J. Lab. Clin. Med , vol.35 , pp. 923-932
    • Sherlock, S.1    Bearn, A.G.2    Billing, B.H.3    Paterson, J.C.4
  • 103
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., and Guengerich, F. P. 1994. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther. 270:414-423.
    • (1994) J. Pharmacol. Exp. Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 104
    • 0002594076 scopus 로고
    • Age changes in basal respiratory measurements and metabolism in males
    • Shock, N. W. and Yiengst, M. J. 1955. Age changes in basal respiratory measurements and metabolism in males. J. Gerontol. 10:31-40.
    • (1955) J. Gerontol , vol.10 , pp. 31-40
    • Shock, N.W.1    Yiengst, M.J.2
  • 105
    • 0005910491 scopus 로고    scopus 로고
    • Geriatric clinical pharmacology
    • eds. H. Kalant and W. H. E. Roschlau, 6th ed, pp, New York: Oxford University Press
    • Sitar, D. S. 1998. Geriatric clinical pharmacology. In Principles of medical pharmacology, eds. H. Kalant and W. H. E. Roschlau, 6th ed., pp. 820-829. New York: Oxford University Press.
    • (1998) Principles of medical pharmacology , pp. 820-829
    • Sitar, D.S.1
  • 106
  • 108
    • 0030973784 scopus 로고    scopus 로고
    • Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions
    • Sotaniemi, E. A., Arranto, A. J., Pelkonen, O., and Pasanen, M. 1997. Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions. Clin. Pharmacol. Ther. 61:331-339.
    • (1997) Clin. Pharmacol. Ther , vol.61 , pp. 331-339
    • Sotaniemi, E.A.1    Arranto, A.J.2    Pelkonen, O.3    Pasanen, M.4
  • 110
    • 0014995132 scopus 로고
    • Age changes in the human kidney of the different races
    • Tauchi, H., Tsuboi, K., and Okutomi, J. 1971. Age changes in the human kidney of the different races. Gerontologia 17:87-97.
    • (1971) Gerontologia , vol.17 , pp. 87-97
    • Tauchi, H.1    Tsuboi, K.2    Okutomi, J.3
  • 111
    • 0023928739 scopus 로고
    • Regional distribution of cardiac output at rest and during exercise in patients with exertional angina pectoris before and after nifedipine therapy
    • Thomson, A., Fletcher, P. J., Harris, P. J., Freedman, B., and Kelly, D. T. 1988. Regional distribution of cardiac output at rest and during exercise in patients with exertional angina pectoris before and after nifedipine therapy. J. Am. Coll. Cardiol. 11:837-842.
    • (1988) J. Am. Coll. Cardiol , vol.11 , pp. 837-842
    • Thomson, A.1    Fletcher, P.J.2    Harris, P.J.3    Freedman, B.4    Kelly, D.T.5
  • 113
    • 0026876109 scopus 로고
    • Laboratory values in fit aging individuals-Sexagenarians through centenarians
    • Tietz, N. W., Shuey, D. F., and Wekstein, D. R. 1992. Laboratory values in fit aging individuals-Sexagenarians through centenarians. Clin. Chem. 38:1167-1185.
    • (1992) Clin. Chem , vol.38 , pp. 1167-1185
    • Tietz, N.W.1    Shuey, D.F.2    Wekstein, D.R.3
  • 115
    • 0037241174 scopus 로고    scopus 로고
    • Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans
    • Wang, Z., Hall, S. D., Maya, J. F., Li, L., Asghar, A., and Gorski, J. C. 2003. Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. Br. J. Clin. Pharmacol. 55:77-85.
    • (2003) Br. J. Clin. Pharmacol , vol.55 , pp. 77-85
    • Wang, Z.1    Hall, S.D.2    Maya, J.F.3    Li, L.4    Asghar, A.5    Gorski, J.C.6
  • 116
    • 0024708942 scopus 로고
    • Reference values for resting blood flow to organs of man
    • Williams, L., and Leggett, R. 1989. Reference values for resting blood flow to organs of man. Clin. Phys. Physiol. Meas. 10:187-217.
    • (1989) Clin. Phys. Physiol. Meas , vol.10 , pp. 187-217
    • Williams, L.1    Leggett, R.2
  • 118
    • 0024241308 scopus 로고
    • The effect of age upon the affinity of microsomal mono-oxygenase enzymes for substrate in human liver
    • Wynne, H. A., Mutch, E., James, O. F., Wright, P., Rawlins, M. D., and Woodhouse, K. W. 1988. The effect of age upon the affinity of microsomal mono-oxygenase enzymes for substrate in human liver. Age Ageing 17:401-405.
    • (1988) Age Ageing , vol.17 , pp. 401-405
    • Wynne, H.A.1    Mutch, E.2    James, O.F.3    Wright, P.4    Rawlins, M.D.5    Woodhouse, K.W.6
  • 119
    • 0024565751 scopus 로고
    • The effect of age upon liver volume and apparent liver blood flow in healthy man
    • Wynne, H. A., Cope, L. H., Mutch, E., Rawlins, M. D., Woodhouse, K. W., and James, O. F. 1989. The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology 9:297-301.
    • (1989) Hepatology , vol.9 , pp. 297-301
    • Wynne, H.A.1    Cope, L.H.2    Mutch, E.3    Rawlins, M.D.4    Woodhouse, K.W.5    James, O.F.6


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