Nonhematotoxic naphthalene diimide modified by polyamine: Synthesis and biological evaluation

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3502-3512

  Wang, Yuxia ^a   Zhang, Xingbo ^a   Zhao, Jin ^a   Xie, Songqiang ^a   Wang, Chaojie ^a  

^a HENAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(2 DIMETHYLAMINO)ETHYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2 [2 (2 DIMETHYLAMINO)ETHYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2 [3 [3 (3 AMINOPROPYLAMINO)PROPYLAMINO]PROPYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2 [3 [3 (3 BUTOXYCARBONYLAMINOPROPYLBUTOXYCARBONYLAMINO)PROPYLBUTOXYCARBONYL]PROPYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2 [3 [4 (3 AMINOPROPYLAMINO)BUTYLAMINO]PROPYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2 [3 [4 (3 BUTOXYCARBONYLAMINOPROPYLBUTOXYCARBONYLAMINO)BUTYLBUTOXYCARBONYLAMINO]PROPYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2 [4 (4 AMINOBUTYLAMINO)BUTYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2 [4 (4 BUTOXYCARBONYLAMINOBUTYLBUTOXYCARBONYLAMINO)BUTYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2 [4 [4 (4 AMINOBUTYLAMINO)BUTYLAMINO]BUTYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2 [4 [4 (4 BUTOXYCARBONYLAMINOBUTYLBUTOXYCARBONYLAMINO)BUTYLBUTOXYCARBONYLAMINO]BUTYL] 6 PHENYL 1H BENZ[DE]ISOQUINOLINE 1,3(2H)DIONE; 2,2' BIS[3 [3 (3 AMINOPROPYLAMINO)PROPYLAMINO]PROPYL] 5,5' BIISOINDOLINE 1,1'3,3' TETRAONE HEXAHYDROCHLORIDE; 2,2' BIS[3 [4 (3 AMINOPROPYLAMINO)BUTYLAMINO]PROPYL] 5,5' BIISOINDOLINE 1,1'3,3' TETRAONE HEXAHYDROCHLORIDE; 2,2' BIS[4 [4 (4 AMINOPBUTYLAMINO)BUTYLAMINO]BUTYL] 5,5' BIISOINDOLINE 1,1'3,3' TETRAONE HEXAHYDROCHLORIDE; 2,7 BIS[3 (3 AMINOPROPYLAMINO)PROPYL]BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8(2H,7H)TETRAONE TETRAHYDROCHLORIDE; 2,7 BIS[3 [3 (3 AMINOPROPYLAMINO)PROPYLAMINO]PROPYL]BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8(2H,7H)TETRAONE HEXAHYDROCHLORIDE; 2,7 BIS[3 [4 (3 AMINOPROPYLAMINO)BUTYLAMINO]PROPYL]BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8(2H,7H)TETRAONE HEXAHYDROCHLORIDE; 2,7 BIS[4 (3 AMINOPROPYLAMINO)BUTYL]BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8(2H,7H)TETRAONE TETRAHYDROCHLORIDE; 2,7 BIS[4 (4 AMINOBUTYLAMINO)BUTYL]BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8(2H,7H)TETRAONE TETRAHYDROCHLORIDE; 2,7 BIS[4 [4 (4 AMINOPROPYLAMINO)BUTYLAMINO]BUTYL]BENZO[LMN][3,8]PHENANTHROLINE 1,3,6,8(2H,7H)TETRAONE HEXAHYDROCHLORIDE; AMONAFIDE; ANTINEOPLASTIC AGENT; NAPHTHALENE DERIVATIVE; NAPHTHALENE DIIMIDE; POLYAMINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLOOD TOXICITY; CANCER CELL CULTURE; CANCER INHIBITION; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; LIFESPAN; LUNG METASTASIS; MITOCHONDRION; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDES; LUNG NEOPLASMS; MICE; NAPHTHALENES; NEOPLASM TRANSPLANTATION; POLYAMINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 84859804224     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300168w     Document Type: Article

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