Aminoglycoside 2″-phosphotransferase IIIa (APH(2″)-IIIa) prefers GTP over ATP: Structural templates for nucleotide recognition in the bacterial aminoglycoside-2″ kinases

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 12893-12903

  Smith, Clyde A ^a   Toth, Marta ^b   Frase, Hilary ^b   Byrnes, Laura J ^a   Vakulenko, Sergei B ^b  

^a SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDES; ANTIBIOTIC RESISTANCE; ATP-BINDING; COFACTORS; EUKARYOTIC PROTEINS; GTP BINDING; KINASE FAMILY; PHOSPHOTRANSFERASES; PROTEIN KINASE; SINGLE NUCLEOTIDES; STRUCTURAL DETERMINANTS; STRUCTURAL TEMPLATES; TYROSINE RESIDUES;

AMINO ACIDS; ANTIBIOTICS; NUCLEOTIDES;

ENZYMES;

ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDE 2 PHOSPHOTRANSFERASE IIIA; GUANOSINE TRIPHOSPHATE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; AMINOGLYCOSIDE 2'' PHOSPHOTRANSFERASE; AMINOGLYCOSIDE 2''-PHOSPHOTRANSFERASE; BACTERIAL PROTEIN; PROTEIN SERINE THREONINE KINASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; CHEMISTRY; CRYSTALLOGRAPHY; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

BACTERIA (MICROORGANISMS); EUKARYOTA;

ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDES; BACTERIAL PROTEINS; CRYSTALLOGRAPHY; DRUG RESISTANCE, BACTERIAL; GUANOSINE TRIPHOSPHATE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES;

EID: 84859747165     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.341206     Document Type: Article

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