Mutations in the aph(2′)-Ic gene are responsible for increased levels of aminoglycoside resistance

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 10, 2002, Pages 3253-3256

  Lee, Hae Kyung ^a   Vakulenko, Sergei B ^a   Clewell, Don B ^a   Lerner, Stephen A ^a   Chow, Joseph W ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; DIBEKACIN; GENE PRODUCT; GENTAMICIN; HABEKACIN; ISEPAMICIN; KANAMYCIN; NEOMYCIN; NETILMICIN; PHOSPHOTRANSFERASE; TOBRAMYCIN;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; ESCHERICHIA COLI; GENE MUTATION; GENETIC CODE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

EID: 0036784038     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.10.3253-3256.2002     Document Type: Article

References (19)

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2. Active site labeling of the gentamicin resistance enzyme AAC(6′)-APH(2″) by the lipid kinase inhibitor wortmannin
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4. A novel gentamicin resistance gene in Enterococcus
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7. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases
8. Detection of the high-level aminoglycoside resistance gene aph(2″)-Ib in Enterococcusfaecium
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12. Active-site labeling of an aminoglycoside antibiotic phosphotransferase (APH(3′)-IIIa)
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