Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 1966-1975

  Stogios, Peter J ^a   Shakya, Tushar ^b   Evdokimova, Elena ^a   Savchenko, Alexei ^a   Wright, Gerard D ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE ARCHITECTURE; ALANINE SUBSTITUTION; AMINOGLYCOSIDE ANTIBIOTICS; AMINOGLYCOSIDES; BACTERIAL RESISTANCE; BINDING AFFINITIES; DISTRIBUTED NETWORKS; ENZYMATIC ACTIVITIES; GTP BINDING; HYDROGEN BOND NETWORKS; HYDROPHOBIC RESIDUES; HYGROMYCIN; HYGROMYCIN B RESISTANCE; INTER-DOMAIN; PHOSPHORYL TRANSFER; PHOSPHOTRANSFERASES; SIDE CHAINS; STRUCTURAL FEATURE; SUBSTRATE SPECIFICITY; SUBSTRATE-BINDING SITES; UNIQUE FEATURES;

AMINO ACIDS; ANTIBIOTICS; BINDING ENERGY; CATALYSTS; ENZYMES; HYDROGEN; HYDROGEN BONDS; NETWORK ARCHITECTURE; SUBSTRATES; SURFACE STRUCTURE;

CRYSTAL STRUCTURE;

ADENOSINE TRIPHOSPHATE; ALANINE; AMINOGLYCOSIDE PHOSPHOTRANSFERASE 4 IA; GUANOSINE TRIPHOSPHATE; HYGROMYCIN B; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYGROMYCIN B; MUTATION, MISSENSE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 78751475029     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.194266     Document Type: Article

References (39)

1. Eisenstein, B. I., Oleson, F. B., Jr., and Baltz, R. H. (2010) Clin. Infect. Dis. 50, (Suppl. 1) S10-S15
2. Wright, G. D., and Thompson, P. R. (1999) Front. Biosci. 4, D9-D21
3. Pittenger, R. C., Wolfe, R. N., Hoehn, P. N., Daily, W. A., and McGuire, J. M. (1953) Antimicro. Chemother. 3, 1268-1278
4. Borovinskaya, M. A., Shoji, S., Fredrick, K., and Cate, J. H. (2008) RNA 14, 1590-1599
5. Cabañas, M. J., Vázquez, D., and Modolell, J. (1978) Eur. J. Biochem. 87, 21-27
6. González, A., Jiménez, A., Vázquez, D., Davies, J. E., and Schindler, D. (1978) Biochim. Biophys. Acta 521, 459-469
7. Gritz, L., and Davies, J. (1983) Gene 25, 179-188
8. Rao, R. N., Allen, N. E., Hobbs, J. N., Jr., Alborn, W. E., Jr., Kirst, H. A., and Paschal, J. W. (1983) Antimicrob. Agents Chemother. 24, 689-695
9. Pardo, J. M., Malpartida, F., Rico, M., and Jiménez, A. (1985) J. Gen. Microbiol. 131, 1289-1298
10. Zalacain, M., Pardo, J. M., and Jiménez, A. (1987) Eur. J. Biochem. 162, 419-422
11. Fong, D. H., Lemke, C. T., Hwang, J., Xiong, B., and Berghuis, A. M. (2010) J. Biol. Chem. 285, 9545-9555
12. Hon, W. C., McKay, G. A., Thompson, P. R., Sweet, R. M., Yang, D. S., Wright, G. D., and Berghuis, A. M. (1997) Cell 89, 887-895
13. Nurizzo, D., Shewry, S. C., Perlin, M. H., Brown, S. A., Dholakia, J. N., Fuchs, R. L., Deva, T., Baker, E. N., and Smith, C. A. (2003) J. Mol. Biol. 327, 491-506
14. Toth, M., Frase, H., Antunes, N. T., Smith, C. A., and Vakulenko, S. B. (2010) Protein Sci. 19, 1565-1576
15. Young, P. G., Walanj, R., Lakshmi, V., Byrnes, L. J., Metcalf, P., Baker, E. N., Vakulenko, S. B., and Smith, C. A. (2009) J. Bacteriol. 191, 4133-4143
16. McKay, G. A., and Wright, G. D. (1996) Biochemistry 35, 8680-8685
17. Otwinowski, Z., and Minor, W. (1997) Methods Enzymology 276, 307-326
18. Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L. W., Kapral, G. J., Grosse-Kunstleve, R. W., McCoy, A. J., Moriarty, N. W., Oeffner, R., Read, R. J., Richardson, D. C., Richardson, J. S., Terwilliger, T. C., and Zwart, P. H. (2010) Acta Crystallogr. D Biol. Crystallogr. 66, 213-221
19. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132
20. Blanc, E., Roversi, P., Vonrhein, C., Flensburg, C., Lea, S. M., and Bricogne, G. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2210-2221
21. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
22. Holm, L., Kääriäinen, S., Rosenström, P., and Schenkel, A. (2008) Bioin- formatics 24, 2780-2781
23. Wallace, A. C., Laskowski, R. A., and Thornton, J. M. (1995) Protein Eng. 8, 127-134
24. Petrey, D., and Honig, B. (2003) Methods Enzymol. 374, 492-509
25. Pon, N. G., and Bondar, R. J. (1967) Anal. Biochem. 19, 272-279
26. Daigle, D. M., Hughes, D. W., and Wright, G. D. (1999) Chem. Biol. 6, 99-110
27. McKay, G. A., Thompson, P. R., and Wright, G. D. (1994) Biochemistry 33, 6936-6944
28. Siregar, J. J., Miroshnikov, K., and Mobashery, S. (1995) Biochemistry 34, 12681-12688
29. Toth, M., Zajicek, J., Kim, C., Chow, J. W., Smith, C., Mobashery, S., and Vakulenko, S. (2007) Biochemistry 46, 5570-5578
30. Tsai, S. F., Zervos, M. J., Clewell, D. B., Donabedian, S. M., Sahm, D. F., and Chow, J. W. (1998) Antimicrob. Agents Chemother. 42, 1229-1232
31. Shakya, T., and Wright, G. D. (2010) Antimicrob. Agents Chemother. 54, 1909-1913
32. Toth, M., Chow, J. W., Mobashery, S., and Vakulenko, S. B. (2009) J. Biol. Chem. 284, 6690-6696
33. Burk, D. L., Hon, W. C., Leung, A. K., and Berghuis, A. M. (2001) Biochemistry 40, 8756-8764
34. Brenner, S. (1987) Nature 329, 21
35. Scheeff, E. D., and Bourne, P. E. (2005) PLoS Comput. Biol. 1, e49
36. Thompson, P. R., Boehr, D. D., Berghuis, A. M., and Wright, G. D. (2002) Biochemistry 41, 7001-7007
37. McKay, G. A., Robinson, R. A., Lane, W. S., and Wright, G. D. (1994) Biochemistry 33, 14115-14120
38. Hanks, S. K., Quinn, A. M., and Hunter, T. (1988) Science 241, 42-52
39. Zheng, J., Trafny, E. A., Knighton, D. R., Xuong, N. H., Taylor, S. S., Ten Eyck, L. F., and Sowadski, J. M. (1993) Acta Crystallogr. D Biol. Crystallogr. 49, 362-365