Low rates of aneuploidy promote tumorigenesis while high rates of aneuploidy cause cell death and tumor suppression

Cellular Oncology

Volumn 30, Issue 5, 2008, Pages 453-

  Weaver, Beth A A ^a   Silk, Alain D ^b   Cleveland, Don W ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTROMERE PROTEIN E; DIMETHYLBENZ[A]ANTHRACENE; PROTEIN MAD2;

ANEUPLOIDY; CANCER INHIBITION; CARCINOGENESIS; CELL DEATH; CENTROMERE; CHROMOSOMAL INSTABILITY; DNA DAMAGE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LETTER; MITOSIS; NONHUMAN; PRIORITY JOURNAL;

ANEUPLOIDY; ANIMALS; CELL DEATH; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL PROTEINS, NON-HISTONE; HUMANS; NEOPLASMS;

EID: 52449132715     PISSN: 15705870     EISSN: None     Source Type: Journal    
DOI: 10.3233/CLO-2008-0445     Document Type: Letter

References (5)

1. T. Boveri, Ueber mehrpolige Mitosen als Mittel zur Analyse des Zellkerns, Vehr. d. phys. med. Ges. zu Wurzburg, N.F. Bd. 35 (1902); available in English translation at: http://8e.devbio.com/article.php?ch= 4&id=24.
2. T. Boveri, Zur Frage der Entstehung maligner Tumoren, Gustav Fischer, Jena, 1914
3. (English translation The Origin of Malignant Tumors by M. Boveri, Williams and Wilkins, Baltimore, 1929).
4. B.A. Weaver, Z.Q. Bonday, F.R. Putkey, G.J. Kops, A.D. Silk and D.W. Cleveland, Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss, J. Cell Biol. 162(4) (2003), 551-563.
5. B.A. Weaver, A.D. Silk, C. Montagna, P. Verdier-Pinard and D.W Cleveland, Aneuploidy acts both oncogenically and as a tumor suppressor, Cancer Cell 11(1) (2007), 25-36.