Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of raptor Thr-908

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 12510-12519

  Wu, Di ^a   Chapman, Jessica R ^b   Wang, Lifu ^a   Harris, Thurl E ^a   Shabanowitz, Jeffrey ^b   Hunt, Donald F ^a,b   Fu, Zheng ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL SUBSTRATES; CELL-CYCLE PROGRESSION; COMPLEX 1; CONSENSUS SEQUENCE; GTP-BINDING PROTEINS; IN-VITRO; IN-VIVO; INTESTINAL CELLS; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MOLECULAR MECHANISM; NUTRIENT-STARVATION; OVER-EXPRESSION; PHOSPHORYLATION SITES; PROTEIN COMPLEXES; PROTEIN KINASE; SIGNALING EVENTS; SIGNALING MECHANISMS;

AMINO ACIDS; ANTIBIOTICS; CELL PROLIFERATION; CYTOLOGY; DNA SEQUENCES; ENZYMES; GENETIC ENGINEERING; MASS SPECTROMETRY; PHOSPHORYLATION; PROTEINS; SUBSTRATES;

CLONE CELLS;

ANTIBODY; INSULIN; INTESTINAL CELL KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN; PROTEIN SERINE THREONINE KINASE; RAPTOR THREONINE 908; RHEB PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIVISION; CELL PROLIFERATION; COMPLEX FORMATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENZYME SUBSTRATE; GENE ACTIVITY; GENE CONTROL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; PHOSPHORYLATION; PHOSPHORYLATION SITE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL PROLIFERATION; CONSENSUS SEQUENCE; G1 PHASE; HEK293 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; MUTAGENESIS, SITE-DIRECTED; NEUROPEPTIDES; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTHREONINE; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;

MAMMALIA; RAPTORES;

EID: 84859514102     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.302117     Document Type: Article

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