Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

Science

Volumn 302, Issue 5647, 2003, Pages 1056-1060

  Yu, Xianghui ^a,b   Yu, Yunkai ^a   Liu, Bindong ^a   Luo, Kun ^a   Kong, Wei ^b   Mao, Panyong ^a   Yu, Xiao Fang ^a,c  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b JILIN UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; IMMUNOLOGY; PROTEINS;

UBIQUITINATION;

VIRUSES;

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; CELL PROTEIN; ELONGIN B; ELONGIN C; PROTEIN CUL5; PROTEIN RBX1; PROTEIN SCF; UNCLASSIFIED DRUG; VIF PROTEIN; VIRUS PROTEIN;

HUMAN IMMUNODEFICIENCY VIRUS;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DEVELOPMENT; GENE ACTIVITY; GENE INACTIVATION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS CELL INTERACTION;

ANIMALS; CARRIER PROTEINS; CELL LINE; CULLIN PROTEINS; GENE PRODUCTS, VIF; HIV-1; HUMANS; MUTATION; NUCLEOSIDE DEAMINASES; PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION; UBIQUITIN; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0242578406     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1089591     Document Type: Article

References (28)

1. J. H. Simon, N. C. Gaddis, R. A. Fouchier, M. H. Malim, Nature Med. 4, 1397 (1998).
2. N. Madani, D. Kabat, J. Viral. 72, 10251 (1998).
3. A. G. Fisher et al., Science 237, 888 (1987).
4. J. S. Gibbs, D. A. Regier, R. C. Desrosiers, AIDS Res. Hum. Retrovir. 10, 607 (1994).
5. D. H. Gabuzda et al., J. Virol. 66, 6489 (1992).
6. N. C. Kan et al., Science 231, 1553 (1986).
7. T. H. Lee et al., Science 231, 1546 (1986).
8. M. Dettenhofer, S. Cen, B. A. Carlson, L. Kleiman, X. F. Yu, J. Virol. 74, 8938 (2000).
9. J. H. Simon, M. H. Malim, J. Virol. 70, 5297 (1996).
10. J. Sodroski et al., Science 231, 1549 (1986).
11. K. Strebel et al., Nature 328, 728 (1987).
12. U. von Schwedler, J. Song, C. Aiken, D. Trono, J. Virol. 67, 4945 (1993).
13. A. M. Sheehy, N. C. Gaddis, J. D. Choi, M. H. Malim, Nature 418, 646 (2002).
14. H. Zhang et al., Nature 424, 94 (2003).
15. R. Mariani et al., Cell 114, 21 (2003).
16. B. Mangeat et al., Nature 424, 99 (2003).
17. D. Lecossier, F. Bouchonnet, F. Clavel, A. J. Hance, Science 300, 1112 (2003).
18. R. S. Harris et al., Cell 113, 803 (2003).
19. K. Iwai et al., Proc. Natl. Acad. Sci. USA. 96, 12436 (1999).
20. C. E. Stebbins, W. G. Kaelin Jr., N. P. Pavletich, Science 284, 455 (1999).
21. R. J. Deshaies, Annu. Rev. Cell. Dev. Biol. 15, 435 (1999).
22. J. N. Harada, A. Shevchenko, D. C. Pallas, A. J. Berk, J. Virol. 76, 9194 (2002).
23. E. Querido et al., Genes Dev. 15, 3104 (2001).
24. W. M. Gray, H. Hellmann, S. Dharmasiri, M. Estelle, Plant Cell 14, 2137 (2002).
25. T. Kamura et al., Science 284, 657 (1999).
26. T. Hori et al., Oncogene 18, 6829 (1999).
27. F. Margottin et al., Mol. Cell 1, 565 (1998).
28. We thank R. Garten, T. Sarkis, R. Markham, M. Dettenhofer, and C. Pickart for advice and technical assistance and D. McClellan for editorial assistance. The following reagents were obtained through the Acquired Immunodifficiency Syndrome (AIDS) Research Reagents Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH: antiserum to HIV-1 Vif (Cat. #2221). Protein identification was performed in the AB Mass Spectrometry/Proteomics Facility at Johns Hopkins School of Medicine with support from National Center for Research Resources shared instrumentation grant 1510-RR14702, the Johns Hopkins Fund for Medical Discovery, and the Institute for Cell Engineering.