Lipoxin A 4 inhibits immune cell binding to salivary epithelium and vascular endothelium

American Journal of Physiology - Cell Physiology

Volumn 302, Issue 7, 2012, Pages

  Chinthamani, Sreedevi ^a   Odusanwo, Olutayo ^b   Mondal, Nandini ^a   Nelson, Joel ^b   Neelamegham, Sriram ^a   Baker, Olga J ^a  

^a School of Dental Medicine at SUNY   (United States)

^b the State University of New York   (United States)

Author keywords

ALX receptor; E selectin; Intercellular cell adhesion molecule 1; Vascular cell adhesion molecule 1

Indexed keywords

CELL ADHESION MOLECULE; CYSTEINYL LEUKOTRIENE 1 RECEPTOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FORMYL PEPTIDE RECEPTOR 2; G PROTEIN COUPLED RECEPTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LEUKOTRIENE RECEPTOR; LIPOXIN A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; FORMYLPEPTIDE RECEPTOR; FPR2 PROTEIN, HUMAN; HSH2D PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR; LEUKOTRIENE D4 RECEPTOR; LIPOXIN; LIPOXIN RECEPTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL INTERACTION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SALIVARY EPITHELIUM; SALIVARY GLAND; SIGNAL TRANSDUCTION; SJOEGREN SYNDROME; UPREGULATION; VASCULAR ENDOTHELIUM; CD4+ T LYMPHOCYTE; CELL COMMUNICATION; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; PHYSIOLOGY; SUBMANDIBULAR GLAND; UMBILICAL VEIN ENDOTHELIAL CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELL COMMUNICATION; CELLS, CULTURED; E-SELECTIN; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1BETA; JURKAT CELLS; LIPOXINS; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, INTERLEUKIN-1; RECEPTORS, LEUKOTRIENE; RECEPTORS, LIPOXIN; RECEPTORS, TUMOR NECROSIS FACTOR; SUBMANDIBULAR GLAND; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84859463280     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00259.2011     Document Type: Article

References (93)

1. Adamson TC 3rd, Fox RI, Frisman DM, Howell FV. Immunohistologic analysis of lymphoid infiltrates in primary Sjogren's syndrome using monoclonal antibodies. J Immunol 130: 203-208, 1983.
2. Aziz KE, McCluskey PJ, Montanaro A, Wakefield D. Vascular endothelium and lymphocyte adhesion molecules in minor salivary glands of patients with Sjogren's syndrome. J Clin Lab Immunol 37: 39-49, 1992.
3. Aziz KE, McCluskey PJ, Wakefield D. Expression of selectins (CD62 E,L,P) and cellular adhesion molecules in primary Sjogren's syndrome: questions to immunoregulation. Clin Immunol Immunopathol 80: 55-66, 1996.
4. Baker N, O'Meara SJ, Scannell M, Maderna P, Godson C. Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. J Immunol 182: 3819-3826, 2009.
5. Baker OJ, Camden JM, Redman RS, Jones JE, Seye CI, Erb L, Weisman GA. Proinflammatory cytokines tumor necrosis factorα and interferon-γ alter tight junction structure and function in the rat parotid gland Par-C10 cell line. Am J Physiol Cell Physiol 295: C1191-C1201, 2008.
6. Baker OJ, Camden JM, Rome DE, Seye CI, Weisman GA. P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecule-1 [corrected] expression and enhances lymphocyte adherence to a human submandibular gland cell line. Mol Immunol 45: 65-75, 2008.
7. Bannenberg G, Moussignac RL, Gronert K, Devchand PR, Schmidt BA, Guilford WJ, Bauman JG, Subramanyam B, Perez HD, Parkinson JF, Serhan CN. Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration. Br J Pharmacol 143: 43-52, 2004.
8. Bernot D, Peiretti F, Canault M, Juhan-Vague I, Nalbone G. Upregu-lation of TNF-alpha-induced ICAM-1 surface expression by adenylate cyclase-dependent pathway in human endothelial cells. J Cell Physiol 202: 434-441, 2005.
9. Bonnans C, Fukunaga K, Levy MA, Levy BD. Lipoxin A(4) regulates bronchial epithelial cell responses to acid injury. Am J Pathol 168: 1064-1072, 2006.
10. Boumba D, Skopouli FN, Moutsopoulos HM. Cytokine mRNA expres-sion in the labial salivary gland tissues from patients with primary Sjogren's syndrome. Br J Rheumatol 34: 326-333, 1995.
11. Brown KD, Claudio E, Siebenlist U. The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis. Arthritis Res Ther 10: 212, 2008.
12. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67: 1033-1036, 1991.
13. Canny G, Levy O, Furuta GT, Narravula-Alipati S, Sisson RB, Serhan CN, Colgan SP. Lipid mediator-induced expression of bacteri-cidal/ permeability-increasing protein (BPI) in human mucosal epithelia. Proc Natl Acad Sci USA 99: 3902-3907, 2002.
14. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 84: 2068-2101, 1994.
15. Chandrasekharan UM, Siemionow M, Unsal M, Yang L, Poptic E, Bohn J, Ozer K, Zhou Z, Howe PH, Penn M, DiCorleto PE. Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo. Blood 109: 1938-1944, 2007.
16. Chiang N, Fierro IM, Gronert K, Serhan CN. Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. J Exp Med 191: 1197-1208, 2000.
17. Claria J, Serhan CN. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci USA 92: 9475-9479, 1995.
18. Cravens PD, Lipsky PE. Dendritic cells, chemokine receptors and autoimmune inflammatory diseases. Immunol Cell Biol 80: 497-505, 2002.
19. Decker Y, McBean G, Godson C. Lipoxin A4 inhibits IL-1 -induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells. Am J Physiol Cell Physiol 296: C1420-C1427, 2009.
20. Dubost JJ, Perrier S, Afane M, Viallard JL, Roux-Lombard P, Baudet-Pommel M, Begue C, Kemeny JL, Sauvezie B. IL-1 receptor antagonist in saliva; characterization in normal saliva and reduced con-centration in Sjogren's syndrome (SS). Clin Exp Immunol 106: 237-242, 1996.
21. Edwards JC, Wilkinson LS, Speight P, Isenberg DA. Vascular cell adhesion molecule 1 and alpha 4 and beta 1 integrins in lymphocyte aggregates in Sjogren's syndrome and rheumatoid arthritis. Ann Rheum Dis 52: 806-811, 1993.
22. Emamian ES, Leon JM, Lessard CJ, Grandits M, Baechler EC, Gaffney PM, Segal B, Rhodus NL, Moser KL. Peripheral blood gene expression profiling in Sjogren's syndrome. Genes Immun 10: 285-296, 2009.
23. Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25: 403-415, 2006.
24. Esmon CT, Taylor FB Jr, Snow TR. Inflammation and coagulation: linked processes potentially regulated through a common pathway medi-ated by protein C. Thromb Haemost 66: 160-165, 1991.
25. Fierro IM, Kutok JL, Serhan CN. Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4). J Pharmacol Exp Ther 300: 385-392, 2002.
26. Filep JG, Zouki C, Petasis NA, Hachicha M, Serhan CN. Anti-inflammatory actions of lipoxin A(4) stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. Blood 94: 4132-4142, 1999.
27. Fiore S, Antico G, Aloman M, Sodin-Semrl S. Lipoxin A4 biology in the human synovium. Role of the ALX signaling pathways in modulation of inflammatory arthritis. Prostaglandins Leukot Essent Fatty Acids 73: 189-196, 2005.
28. Fiore S, Maddox JF, Perez HD, Serhan CN. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J Exp Med 180: 253-260, 1994.
29. Fiore S, Romano M, Reardon EM, Serhan CN. Induction of functional lipoxin A4 receptors in HL-60 cells. Blood 81: 3395-3403, 1993.
30. Fiorucci S, Distrutti E, Mencarelli A, Morelli A, Laufor SA, Cirino G, Wallace JL. Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in re-sponse to aspirin. Br J Pharmacol 139: 1351-1359, 2003.
31. Fiorucci S, Santucci L, Wallace JL, Sardina M, Romano M, del Soldato P, Morelli A. Interaction of a selective cyclooxygenase-2 inhib-itor with aspirin and NO-releasing aspirin in the human gastric mucosa. Proc Natl Acad Sci USA 100: 10937-10941, 2003.
32. Fiorucci S, Wallace JL, Mencarelli A, Distrutti E, Rizzo G, Farneti S, Morelli A, Tseng JL, Suramanyam B, Guilford WJ, Parkinson JF. A beta-oxidation-resistant lipoxin A4 analog treats attenuating inflammation and immune dysfunction. Proc Natl Acad Sci USA 101: 15736-15741, 2004.
33. Fox RI, Kang HI. Pathogenesis of Sjogren's syndrome. Rheum Dis Clin North Am 18: 517-538, 1992.
34. Fox RI, Kang HI, Ando D, Abrams J, Pisa E. Cytokine mRNA expression in salivary gland biopsies of Sjogren's syndrome. J Immunol 152: 5532-5539, 1994.
35. Fujihara T, Fujita H, Tsubota K, Saito K, Tsuzaka K, Abe T, Takeuchi T. Preferential localization of CD8 alpha E beta 7 T cells around acinar epithelial cells with apoptosis in patients with Sjogren's syndrome. J Immunol 163: 2226-2235, 1999.
36. Gewirtz AT, Collier-Hyams LS, Young AN, Kucharzik T, Guilford WJ, Parkinson JF, Williams IR, Neish AS, Madara JL. Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol 168: 5260-5267, 2002.
37. Goh J, Baird AW, O'Keane C, Watson RW, Cottell D, Bernasconi G, Petasis NA, Godson C, Brady HR, MacMathuna P. Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-in-duced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo. J Immunol 167: 2772-2780, 2001.
38. Gronert K, Gewirtz A, Madara JL, Serhan CN. Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. J Exp Med 187: 1285-1294, 1998.
39. Gronert K, Maheshwari N, Khan N, Hassan IR, Dunn M, Laniado Schwartzman M. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J Biol Chem 280: 15267-15278, 2005.
40. Guilford WJ, Bauman JG, Skuballa W, Bauer S, Wei GP, Davey D, Schaefer C, Mallari C, Terkelsen J, Tseng JL, Shen J, Subramanyam B, Schottelius AJ, Parkinson JF. Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo. J Med Chem 47: 2157-2165, 2004.
41. Halse A, Tengner P, Wahren-Herlenius M, Haga H, Jonsson R. Increased frequency of cells secreting interleukin-6 and interleukin-10 in peripheral blood of patients with primary Sjogren's syndrome. Scand J Immunol 49: 533-538, 1999.
42. Hamano H, Saito I, Haneji N, Mitsuhashi Y, Miyasaka N, Hayashi Y. Expressions of cytokine genes during development of autoimmune sialad-enitis in MRL/lpr mice. Eur J Immunol 23: 2387-2391, 1993.
43. Haraldsen G, Kvale D, Lien B, Farstad IN, Brandtzaeg P. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J Immunol 156: 2558-2565, 1996.
44. Henriksson G, Manthorpe R, Bredberg A. Antibodies to CD4 in primary Sjogren's syndrome. Rheumatology (Oxford) 39: 142-147, 2000.
45. Hidalgo A, Peired AJ, Wild MK, Vestweber D, Frenette PS. Complete identification of E-selectin ligands on neutrophils reveals distinct func-tions of PSGL-1, ESL-1, and CD44. Immunity 26: 77-489, 2007.
46. Hirschi KK, D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res 32: 687-698, 1996.
47. Ichiyama T, Hasegawa S, Umeda M, Terai K, Matsubara T, Furu-kawa S. Pranlukast inhibits NF-kappa B activation in human monocytes/ macrophages and T cells. Clin Exp Allergy 33: 802-807, 2003.
48. Jiang W, Hall SR, Moos MP, Cao RY, Ishii S, Ogunyankin KO, Melo LG, Funk CD. Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury. Am J Pathol 172: 592-602, 2008.
49. Jonsson R, Moen K, Vestrheim D, Szodoray P. Current issues in Sjogren's syndrome. Oral Dis 8: 130-140, 2002.
50. Jozsef L, Zouki C, Petasis NA, Serhan CN, Filep JG. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leuko-cytes. Proc Natl Acad Sci USA 99: 13266-13271, 2002.
51. Kisseleva T, Brenner DA. Mechanisms of fibrogenesis. Exp Biol Med (Maywood) 233: 109-122, 2008.
52. 4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium. Am J Physiol Cell Physiol 284: C888-C896, 2003.
53. Kure I, Nishiumi S, Nishitani Y, Tanoue T, Ishida T, Mizuno M, Fujita T, Kutsumi H, Arita M, Azuma T, Yoshida M. Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation. J Pharmacol Exp Ther 332: 541-548, 2010.
54. Lamhamedi-Cherradi SE, Zheng S, Hilliard BA, Xu L, Sun J, Als-headat S, Liou HC, Chen YH. Transcriptional regulation of type I diabetes by NF-kappa B. J Immunol 171: 4886-4892, 2003.
55. Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt BA, Szczeklik W, Drazen JM, Serhan CN. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med 8: 1018-1023, 2002.
56. Ley K, Tedder TF. Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. J Immunol 155: 525-528, 1995.
57. Villalon L, Mamani M, Romanini FE, Catalan Pellet A, Berra A. [Primary Sjogren's syndrome: Expression of NF-kB in minor salivary glands.] Reumatol Clin 6: 292-295, 2010.
58. Lindahl P, Hellstrom M, Kalen M, Betsholtz C. Endothelial-perivascu-lar cell signaling in vascular development: lessons from knockout mice. Curr Opin Lipidol 9: 407-411, 1998.
59. Maddox JF, Hachicha M, Takano T, Petasis NA, Fokin VV, Serhan CN. Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. J Biol Chem 272: 6972-6978, 1997.
60. Makó V, Czúcz J, Weiszhár Z, Herczenik E, Matkó J, Prohászka Z, Cervenak L. Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1, TNF-, and LPS. Cytometry A 77: 962-970, 2010.
61. Malyszko J. Mechanism of endothelial dysfunction in chronic kidney disease. Clin Chim Acta 411 1412-1420, 2010.
62. Marathe DD, Buffone A Jr, Chandrasekaran EV, Xue J, Locke RD, Nasirikenari M, Lau JT, Matta KL, Neelamegham S. Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins. Blood 115: 1303-1312, 2010.
63. Marcus AJ, Safier LB. Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis. FASEB J 7: 516-522,1993.
64. McMurray RW. Adhesion molecules in autoimmune disease. Semin Arthritis Rheum 25: 215-233, 1996.
65. Nakajima H, Sano H, Nishimura T, Yoshida S, Iwamoto I. Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J Exp Med 179: 1145-1154, 1994.
66. Norel X, Brink C. The quest for new cysteinyl-leukotriene and lipoxin receptors: recent clues. Pharmacol Ther 103: 81-94, 2004. 67a.Odusanwo O, Chinthamani S, McCall A, Duffey ME, Baker OJ. Resolvin Dl prevents TNF--mediated disruption of salivary epithelial formation. Am J Physiol Cell Physiol (January 11, 2012). doi:10.1152/ ajpcell.00207.2011.
67. O'Hara R, Murphy EP, Whitehead AS, FitzGerald O, Bresnihan B. Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis. Arthritis Rheum 50: 1788-1799, 2004.
68. Okada N, Fukagawa K, Takano Y, Dogru M, Tsubota K, Fujishima H, Matsumoto K, Nakajima T, Saito H. The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathy. Invest Ophthalmol Vis Sci 46: 4512-4518, 2005.
69. Olofsson AM, Arfors KE, Ramezani L, Wolitzky BA, Butcher EC, von Andrian UH. E-selectin mediates leukocyte rolling in interleukin-1-treated rabbit mesentery venules. Blood 84: 2749-2758, 1994.
70. Oxholm P, Daniels TE, Bendtzen K. Cytokine expression in labial salivary glands from patients with primary Sjogren's syndrome. Autoim-munity 12: 185-191, 1992.
71. Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Hiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad Sci USA 107: 15193-15198, 2010.
72. Price EJ, Venables PJ. The etiopathogenesis of Sjogren's syndrome. Semin Arthritis Rheum 25: 117-133, 1995.
73. Ross R. Cell biology of atherosclerosis. Annu Rev Physiol 57: 791-804, 1995.
74. Saito I, Terauchi K, Shimuta M, Nishiimura S, Yoshino K, Takeuchi T, Tsubota K, Miyasaka N. Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjogren's syndrome. J Clin Lab Anal 7: 180-187, 1993.
75. Schmidt A, Goepfert C, Feitsma K, Buddecke E. Lovastatin-stimulated superinduction of E-selectin, ICAM-1 and VCAM-1 in TNF-alpha acti-vated human vascular endothelial cells. Atherosclerosis 164: 57-64, 2002.
76. Scholz D, Devaux B, Hirche A, Potzsch B, Kropp B, Schaper W, Schaper J. Expression of adhesion molecules is specific and time-dependent in cytokine-stimulated endothelial cells in culture. Cell Tissue Res 284: 415-423, 1996.
77. Serhan CN. Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol 25: 101-137, 2007.
78. Serhan CN, Krishnamoorthy S, Recchiuti A, Chiang N. Novel anti-inflammatory-pro-resolving mediators and their receptors. Curr Top Med Chem 11: 629-647, 2011.
79. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol 6: 1191-1197, 2005.
80. Sfikakis PP, Mavrikakis M. Adhesion and lymphocyte costimulatory molecules in systemic rheumatic diseases. Clin Rheumatol 18: 317-327,1999.
81. Shen L, Suresh L, Li H, Zhang C, Kumar V, Pankewycz O, Ambrus JL Jr. IL-14 alpha, the nexus for primary Sjogren's disease in mice and humans. Clin Immunol 130: 304-312, 2009.
82. Shimizu Y, Newman W, Tanaka Y, Shaw S. Lymphocyte interactions with endothelial cells. Immunol Today 13: 106-112, 1992
83. Shirasuna K, Sato M, Miyazaki T. A myoepithelial cell line established from a human pleomorphic adenoma arising in minor salivary gland. Cancer 45: 297-305, 1980.
84. Sjostrom M, Jakobsson PJ, Heimburger M, Palmblad J, Haeggstrom JZ. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. Eur J Biochem 268: 2578-2586, 2001.
85. Sodin-Semrl S, Taddeo B, Tseng D, Varga J, Fiore S. Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases. J Immunol 164: 2660-2666, 2000.
86. Springer TA. Adhesion receptors of the immune system. Nature 346: 425-434, 1990.
87. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76: 301-314, 1994.
88. St Clair EW, Angellilo JC, Singer KH. Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjogren's syndrome. Arthritis Rheum 35: 62-66, 1992.
89. 4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflamma-tory receptors. J Exp Med 185: 1693-1704, 1997.
90. Tsunawaki S, Nakamura S, Ohyama Y, Sasaki M, Ikebe-Hiroki A, Hiraki A, Kadena T, Kawamura E, Kumamaru W, Shinohara M, Shirasuna K. Possible function of salivary gland epithelial cells as nonprofessional antigen-presenting cells in the development of Sjogren's syndrome. J Rheumatol 29: 1884-1896, 2002.
91. Turkcapar N, Sak SD, Saatci M, Duman M, Olmez U. Vasculitis and expression of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin in salivary glands of patients with Sjogren's syndrome. J Rheumatol 32: 1063-1070, 2005.
92. Xanthou G, Tapinos NI, Polihronis M, Nezis IP, Margaritis LH, Moutsopoulos HM. CD4 cytotoxic and dendritic cells in the immuno-pathologic lesion of Sjogren's syndrome. Clin Exp Immunol 118: 154-163, 1999.
93. Zhang Y, Neelamegham S. Estimating the efficiency of cell capture and arrest in flow chambers: study of neutrophil binding via E-selectin and ICAM-1. Biophys J 83: 1934-1952, 2002.